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The fatigue crack propagation rate is influenced by various mechanisms at the very vicinity of the crack tip, e.g., local plasticity and/or creep, microcracking, crack branching, and crack closure induced by plasticity and roughness. To study these mechanisms and their influence on crack propagation rate during different loadings, in situ scanning electron microscope studies have been performed. T
This article analyses the negotiation of German identities in two films of the ‘newer German cinema’: Sonnenallee/Sun Alley (Haussmann 1999) and Schultze gets the blues (Schorr 2003). It argues that the former represents a defiant stance towards a dominant West German narrative which devalorizes the lived experiences of former GDR citizens. As a consequence, east and west are consolidated as relev
The function of alpha-cells in patients with type 2 diabetes is often disturbed; glucagon secretion is increased at hyperglycaemia, yet fails to respond to hypoglycaemia. A crucial mechanism behind the fine-tuned release of glucagon relies in the exocytotic machinery including SNARE proteins. Here, we aimed to investigate the temporal role of syntaxin 1A and SNAP-25 in mouse alpha-cell exocytosis.
Adsorption of glycine on Pt{111} under UHV conditions and in different aqueous environments was studied by XPS (UHV and ambient pressure) and NEXAFS. Under UHV conditions, glycine adsorbs in its neutral molecular state up to about 0.15 ML Further deposition leads to the formation of an additional zwitterionic species, which is in direct contact with the substrate surface, followed by the growth of
Chemotherapy of castration resistant prostate cancer (CRPC) is based on taxane formulations worldwide. Only 30-50 % of patients respond to this therapy and the exact cellular mechanisms of taxane resistance in PC cells are not fully elucidated. There is convincing evidence that androgen receptor (AR) is affected by exposure to these compounds. The studies presented in this doctoral thesis identify
This special issue of Professions & Professionalism seeks to explain the transition of occupations from non-professions to professions and the conditions and causes that generate professions (i.e., the bases of professionalization). Empirically, we use the histories of the Swedish professions, positing that these histories have several close similarities (and, of course, differences) with thos
Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to hypothalamic pathology and dysfunction of hypothalamo-pituitary axes.
We performed transient absorption (TA) measurements on CP29 minor light-harvesting complexes that were reconstituted in vitro with either violaxanthin (Vio) or zeaxanthin (Zea) and demonstrate that the Zea-bound CP29 complexes exhibit charge-transfer (CT) quenching that has been correlated with the energy-dependent quenching (qE) in higher plants. Simulations of the difference TA kinetics reveal t
Polarized light (PL) sensitivity is relatively well studied in a large number of invertebrates and some fish species, but in most other vertebrate classes, including birds, the behavioural and physiological mechanism of PL sensitivity remains one of the big mysteries in sensory biology. Many organisms use the skylight polarization pattern as part of a sun compass for orientation, navigation and in
Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed whe
This thesis aimed to investigate possibilities to utilize death certificates in cancer epidemiology by analyzing nationwide databases from Sweden. Excessive information is available when investigating causes of death in cancer patients, including comorbidities and metastatic patterns. We used the Swedish Family- Cancer Database, which includes data from e.g. the Cause of Death Register and the Can
Smooth muscle cells in the urinary bladder are involved in the control of urine filling and emptying. We have used mice to study the contractile regulation of urinary bladder smooth muscle during the fetal period. We found that nerve-induced contractions are mainly dependent on muscarinic receptor activation in the newborn whereas adult bladders are equally dependent on muscarinic and purinergic r
A largely extended experimental knowledge of the Cu-61(29)32 nucleus has been obtained from three experiments. Excited states in Cu-61 were produced via the fusion-evaporation reaction Si-28(Ar-36, 3p)Cu-61. In addition to the Ge array GAMMASPHERE, neutron and charged-particle detectors placed around the target position were used for high-performance particle spectroscopy. The constructed level sc
Popular Abstract in Swedish Huntingtons sjukdom (HS) är en ärftlig och dödlig sjukdom som karakteriseras av ofrivilliga, danslika rörelser vilket gjort att den i folkmun kallas för danssjuka. Diagnosen ställs när de motoriska problemen (ofrivilliga rörelserna) uppträder, vanligtvis i medelåldern, och dessa ökar sedan gradvis och den drabbade personen avlider på grund av sjukdomen efter cirka 15-25Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. The hypothalamus has emerged as an
The starting point for this study is the transformation that the latest decade has occurred in security and defence affairs. The focal point is the big challenges that these developments have implied for national armed forces. The perspective chosen to describe and analyse this is that of professionalism, and the object of study is that of the Swedish military. The aim of the study is in broad ter
A large number of photovoltaic systems have been installed in developing countries around the world during numerous projects. The goal is often to improve the quality of life in rural areas often lacking electricity. Many of these installations provide important services such as lighting and charging of various devices. However, when the projects are finished, there is a large risk that maintenanc
Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers.
We explore the emergence of two contemporary mega water projects in Turkey that are designed to meet the demands of the country's major urban centers. Moreover, we analyze how policy makers in the water sector frame problems and solutions. We argue that these projects represent a tendency to depoliticize water management and steer away from controversial issues of water allocation by emphasizing l
Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis with both anticitrullinated protein antibodies (ACPA) and auto-antibodies against the citrullinating enzyme, peptidylarginine deim
