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Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands

Autoantibodies are an important marker of human autoimmune diseases and the development of simple, precise and reproducible immunoassays to detect autoantibodies is important to our understanding of human autoimmunity. GAD65 autoantibodies occur frequently in insulin-dependent diabetic patients and is a useful marker for IDDM. A RIA to detect immunoreactive GAD65 has not been described. In the pre

Prevention in the elderly: A necessary priority for general practitioners

Prevention is viewed as a key issue for general practice, yet there is a lack of evidence regarding general practitioners’ interventions in both middle-aged and elderly people. This is despite the fact that recommendations and key indicators for monitoring the use of clinical preventive strategies aimed at these groups are available and that both the World Health Organization and European Commissi

Superinduction of cytokine gene transcription by ciprofloxacin

In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-γ production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1α, IL-2 and its receptor, IFN-γ, IL-3, IL-4, granulocyte- macrophage/CSF, TNF-α, and

Congested curricula and incompatible goals: the curious absence of ICT from school-based learning in China

Worldwide, information and communication technologies (ICT), particularly in the sense of digital literacy, are increasingly considered as both inevitable and indispensable parts of the school curriculum. Also, international student assessment studies like PISA have on several occasions assessed computer and information literacy. Additionally, classrooms, teaching and learning, as well as school a

Mapping the cell binding site on high molecular weight kininogen domain 5

Investigations mapped the region(s) on the light chain of high molecular weight kininogen (HK) that participates in cell binding. Sequential and overlapping peptides of domain 5 (D5(H)) were synthesized to determine its cell binding site(s). Three peptides from non-overlapping regions on D5(H) were found to inhibit biotin-HK binding to endothelial cells. Peptides GKE19 and HNL21 weakly inhibited b

THE INSTITUTE REPRESENTATION AT THE UNITED NATIONS: HISTORICAL EVOLUTION, LEGAL STATUS AND FEATURES

This article examines the historical genesis, nature, features and international legal status of the Institute representation at the UN, both on the territory of the member states and of the member states to the UN. An attempt was made to reveal the status and characteristics of the offices of both the UN and its specialized agencies. On the basis of the analysis, proposals were made to strengthen

UTVÄRDERING AV SI-VERKSAMHETEN VID LUNDS UNIVERSITET 2016/17

Samverkansinlärning/Supplemental Instruction (SI) är en pedagogisk metod som syftar till att öka genomströmningen i svåra kurser. Metoden uppstod i USA vid University of Missouri Kansas City i mitten på 1970-talet och har därefter spridits till mer än 1500 högre lärosäten i ett trettiotal länder (Martin, 2008). Kort kan SI sägas vara ett studentdrivet komplement till ordinarie undervisning vid hög

Optimisation of the resource efficiency of food manufacturing via the Internet of Things

The food sector is currently very inefficient due to a large amount of food waste it generates, and the volumes of water and energy used. This problem is aggravated by increasing economic costs and stricter regulations associated with the disposal and treatment of food waste, carbon emissions and wastewater discharge. Because of this, resource efficiency is key to a sustainable food system. In thi

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance

Bacteria utilize complement regulators as a means of evading the host immune response. Here, we describe protocols for evaluating the role vitronectin acquisition at the bacterial cell surface plays in resistance to the host immune system. Flow cytometry experiments identified human plasma vitronectin as a ligand for the bacterial receptor outer membrane protein H of Haemophilus influenzae type f.

Pop-up Mosques, Social Media Adhan, and the Making of Female and LGBTQ-Inclusive Imams

The last few decades have seen the appearance of a number of mosques that do not constitute buildings; they are mosques without bricks. This article therefore defines a new concept, the pop-up mosque, as an analytical term for the temporary conversion of an other-purposed space into a mosque, which is used for Islamic rituals such as Friday prayer and marriages. The pop-up mosque can produce relig

Teacher educators' self-reported preparedness to teach students with special educational needs in higher education

This research explores teacher educators' self-reported preparedness to teach students with special educational needs. Teacher educators are concerned with preparing the next generation of teachers who will, in turn, be addressing the needs of students with special educational needs within schools. Being able to address this important task also in their own teaching at the teacher education progra