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Generating proteomic maps of membrane proteins, common targets for therapeutic interventions and disease diagnostics, has turned out to be a major challenge. Antibody-based microarrays are among the novel rapidly evolving proteomic technologies that may enable global proteome analysis to be performed. Here, we have designed the first generation of a scaleable human recombinant scFv antibody microa

The aim of this study was to test the feasibility of two instruments within an Icelandic context, the Brief Symptom Inventory 18 (BSI 18) and the Ways of Coping Inventory – Cancer Version (WOC-CA) with specific focus on gender and type of treatment and coping techniques among cancer patients during time of treatment. The sample consisted of 40 cancer patients in three oncology outpatient clinics i

Repeated immunization of mice with bacterial superantigens induces extensive deletion and anergy of reactive CD4 T cells. Here we report that the in vitro proliferation anergy of CD4 T cells from TCR transgenic mice immunized three times with staphylococcal enterotoxin B (SEB) (3x SEB) is partially due to an increased frequency of Foxp3(+) CD4 T cells. Importantly, reduced number of conventional C

Background: There has been substantial progress in epidemiological research on prostate cancer over the last decade. An area of increasing interest is the possible role of sexual activity and history of sexually transmitted infections as a risk factor for prostate cancer. Specific sexually transmitted infections have only inconsistently been associated with prostate cancer, with positive associati

Popular Abstract in Swedish Typ 2-diabetes mellitus ökar över hela världen med en trend av minskande debutålder. Sjukdomen är ett komplext natur som kan ses som en rad olika metabola sjukdomar med delvis lika symtom, men med helt olika bakgrundsorsaker. Gemensamt för alla varianter av diabetes är att blodsockret är förhöjt även vid fasta. Typ 2-diabetes kännetecknas av insulinresistens och en progType 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. The data showed abnormally increased expression of inducible nitric oxide synthase (iNOS) protein in th

Routine coagulation tests have a low predictability for perioperative bleeding complications, and spinal hematoma after removal of epidural catheters is very infrequent. Thromboelastometry and point-of-care platelet aggregometry may improve hemostatic monitoring but have not been studied in the context of safety around epidural removal.

Popular Abstract in Swedish Solenergi kommer att vara en av de viktigaste miljövänliga energikällorna i framtiden, vilket innebär ökat antal solpaneler (för el och värme) som integreras i våra hus men också som fristående produktionsanläggningar. När man planerar framtida hus och stadsdelar är det viktigt att skapa de bästa förutsättningarna för solenergi eftersom hus och stadsdelar finns kvar i fEnergy use in buildings accounts for a significant proportion of the total energy use in many countries. While past and current buildings have solely been energy consumers, future buildings will, besides using less energy, also need to produce (part of ) the required energy on site with renewables. Solar energy is generally very suitable for producing this on-site renewable energy. Although solar

We compared seroreactivity to Human papillomavirus (HPV) antigens measured with two different high-throughput assays. One method used GST-L1 fusion proteins and the other heparin-bound HPV pseudovirions as antigens and both methods used multiplexed fluorescent beads for detection. For six HPV types (5, 6, 15, 16, 32 and 38), seroreactivity could be measured in parallel for 434 serum samples from n

The aim was to explore the use of an activity-based approach to determine the validity of a set of housing standards addressing accessibility. This included examination of the frequency and the extent of accessibility problems among older people with physical functional limitations who used no mobility device (n = 10) or who used a wheelchair (n = 10) or a rollator (n = 10). The setting was a kitc

We wanted to investigate if plasma levels of antimicrobial polypeptides (AMPs) are increased in severe sepsis and if they correlate with severity and mortality. Samples were collected from 31 sepsis patients at the intensive care unit. The Sequential Organ Failure Assessment (SOFA) score and 90-day mortality were registered, and inflammatory markers and AMP levels were measured by ELISA. A median

The purpose of this study was to describe child health centre (CHC) nurses' views of managing parental groups during early childhood. All 311 CHC nurses working within the Swedish CHC system in one county were asked to complete a web-based questionnaire. Findings showed that although the CHC nurses were experienced, several found group leadership challenging and difficult. The need for specialized

Abstract Aim: The aim of this study was to investigate how occupational therapists in Sweden administer housing adaptation cases, how they perceive the housing adaptation process, and which improvements they consider necessary. Methods: A total of 1 679 occupational therapists employed by the county councils or the local authorities (and involved in housing adaptations) participated in a web-based

The 30 articles in this special section cover a broad range among the following areas: advanced bioimaging; multifunctional endoscopy; novel approaches in biophotonic diagnostics and therapeutics; advanced biophotonic sensing techniques; laser-cell interactions; photoacoustics and terahertz biophotonics; nanobiophotonics; and novel laser, fiber-optics and electrooptics biophotonic tools, and devic

Spinocerebellar systems are likely to be crucial for cerebellar hallmark functions such as coordination. However, in terms of cerebellar functional analyses, these are perhaps among the least explored systems. The aim of the present study is to achieve activation of a single component of the spinocerebellar systems and to explore to what extent it can influence the spike output of granule cells, G

Pathogenic microbes acquire the human plasma protein plasminogen to their surface. In this article, we characterize binding of this important coagulation regulator to the respiratory pathogen nontypeable Haemophilus influenzae and identify the Haemophilus surface protein E (PE) as a new plasminogen-binding protein. Plasminogen binds dose dependently to intact bacteria and to purified PE. The plasm