Search results

Src homology 2 (SH2) domains recognize phosphotyrosine (pY)-containing sequences and thereby mediate their association to ligands. Bruton's tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase, in which mutations cause a hereditary immunodeficiency disease, X-linked agammaglobulinemia (XLA). Mutations have been found in all Btk domains, including SH2, We have analyzed the structural and

We review and extend the list of stability and convergence properties satisfied by Runge-Kutta (RK) methods that are associated with Summation-By-Parts (SBP) operators, herein called RK-SBP methods. The analysis covers classical, generalized as well as upwind SBP operators. Previous work on the topic has relied predominantly on energy estimates. In contrast, we derive all results using a purely al

In the context of range-independent solid media, we propose a well-conditioned dynamic stiffness matrix for an elastic layer sitting over an elastic half-space. This formulation overcomes the well-known problem of numerical ill-conditioning when solving the system of equations for deep-layered strata. The methodology involves the exact solutions of transformed ordinary differential equations in th

This paper tests how gender stereotypes may result in biased student evaluations of teaching (SET). We thereby contribute to an ongoing discussion about the validity and use of SET in academia. According to social psychological theory, gender biases in SET may occur because of a lack of fit between gender stereotypes, and the professional roles individuals engage in. A lack of fit often leads to m

Biomedicine is typically defined as the branch of medicine that is based on the principles of biology and biochemistry. A central tenet for biomedicine is the notion of disease and therapeutic specificity, i.e. the idea of tailored treatments for discrete disorders underpinned by specific pathologies. The present paper is concerned with how notions of disease and therapeutic specificity guide biom

This article examines the production of climate-related loss, specifically loss of access to land, among Indigenous and ethnic minority farming communities in northeastern Cambodia. We analyse how rapid socio-environmental and political-economic changes are eroding smallholder farmers' capacities to cope with climate impacts and can lead to what we call climate-related loss. We show how climate ch

This article develops Border Work (BW) as a theoretical concept and methodological approach, underexplored in socio-legal scholar-activism, through analysing two distinct examples: Noor, who applied for protection, and her individual and collective struggle for residency and the making of a manifesto against borders. While both examples depart from feminist methodology, the differences are stark:

In light of recent global crises and growing geopolitical uncertainties, the importance of resilience at the individual, organizational, and societal levels has become more apparent. This chapter explores the role of communication capabilities in building resilience – the ability to adapt to a changing environment and to mitigate and recover from crises. Based on existing literature, we propose an

This chapter highlights the centrality of atmospheres in tightly controlled environments like courtrooms and youth detention homes. In courtrooms, social control is achieved through affective arrangements, such as reading emotional cues and using touch or its avoidance to manage order. Legal professionals rely on their ability to sense and act on shifting atmospheres as part of their implicit skil

Det svenska ränteavdraget är en omdiskuterad skattepolitisk åtgärd som ofta anses bidra till både hög skuldsättning och driva upp bostadspriser, samtidigt som det underlättar för hushåll med svag ekonomi genom minskande boendekostnader. Det finns osäkerheter kring vilka ekonomiska konsekvenser som sker vid avskaffande, särskilt på lokal nivå. Ränteavdraget är ett avdrag som minskar den skatt du bThe Swedish mortgage interest deduction is a central tax policy instrument that influences both household debt and housing prices. This study examines how the removal of the interest deduction would affect the housing market in Malmö, a city experiencing population growth and limited land availability. The analysis is based on a counterfactual simulation using actual transaction data and mortgage

This chapter examines elite polarisation as a challenge to governance in parliamentary democracies. We emphasise the distinction between ideological polarisation based on substantive policy disagreements from affective polarisation, characterised by identity-based animosity that creates barriers to cooperation even when policy compromise might otherwise be possible. While parliamentary regimes hav

Bacteria utilize complement regulators as a means of evading the host immune response. Here, we describe protocols for evaluating the role vitronectin acquisition at the bacterial cell surface plays in resistance to the host immune system. Flow cytometry experiments identified human plasma vitronectin as a ligand for the bacterial receptor outer membrane protein H of Haemophilus influenzae type f.

The last few decades have seen the appearance of a number of mosques that do not constitute buildings; they are mosques without bricks. This article therefore defines a new concept, the pop-up mosque, as an analytical term for the temporary conversion of an other-purposed space into a mosque, which is used for Islamic rituals such as Friday prayer and marriages. The pop-up mosque can produce relig

Investigations mapped the region(s) on the light chain of high molecular weight kininogen (HK) that participates in cell binding. Sequential and overlapping peptides of domain 5 (D5(H)) were synthesized to determine its cell binding site(s). Three peptides from non-overlapping regions on D5(H) were found to inhibit biotin-HK binding to endothelial cells. Peptides GKE19 and HNL21 weakly inhibited b