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b1 integrins are thought to play a central role in maintaining lymphocytes within mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial cellular components within and underlying the basement membrane. In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small intestine were
How is meaning created by a poem? Through the invisible ideas and thoughts conveyed by the text or through the physical presence of book, paper and print? In Bodies of Poems the author argues that the material properties of poetic texts are meaningful in their own right but often ignored and made invisible in poetry criticism. Through a number of examples ranging from the introduction of print tec
The objectives of the work presented in this thesis have been to develop molecular methods for (i) detection of Clostridium botulinum in food and clinical samples, and (ii) monitoring the expression of the neurotoxin gene, cnt, during different growth phases and under different growth conditions. For the diagnosis of botulism, a real-time PCR-based method including an internal amplification contr
NKT cells m the mouse recognize antigen in the context of the MHC class I-like molecule CD1d and play an important role in peripheral tolerance and protection against autoimmune and other diseases NKT cells are usually activated by CD1d-presented lipid antigens However, peptide recognition m the context of CD 1 has also been documented, although no self-peptide ligands have been reported to date H
SUMMARY Because of the strong causal relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods for HPV-testing with genotyping: A high-throughput HPV genotyping met
Background and Purpose 1-adrenoceptor (-AR) antagonists may facilitate ureter stone passage in humans. We aimed to study effects by the 1A-AR selective antagonist silodosin (compared to tamsulosin and prazosin) on ureter pressures in a rat model of ureter obstruction, and on contractions of human and rat isolated ureters. Experimental Approach After ethical approval, ureters of male rats were cann
The chapter reviews evidence for the bodily mimesis hypothesis, which states that the evolution of language was preceded by an adaptation for improved volitional control of the body, giving our ancestors advantages in the domains of imitation, empathy, and gestural communication. Much of this evidence is also shared by other gesture-first theories of language origins, but they face the problem of
Cutaneous human papillomaviruses (HPVs) are a heterogeneous, nonmonophyletic assembly, comprising about 50 characterized types and at least 133 isolates putatively representing new types. Their natural history of infection and potential association with nonmelanoma skin cancer are not well understood. Several PCR systems have been developed that amplify a broad spectrum of cutaneous HPVs. However,
Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib. A collection of clinical Haemophilus influenzae isolates was tested and the majority of encapsulated and unencapsulated bound F
Objective: The aim of this study was to increase the understanding of stroke survivors' thoughts and experiences from returning to work after stroke. Methods: Semi-structured interviews were carried out with twelve persons, based on a thematic interview guide. A qualitative content analyse were performed. Results: The main theme; was Striving for optimal function at work creates mixed feelings of
Individual voice and speech characteristics are important for earwitness identification. A target-absent line-up with six foils was used to analyse the influence of voice and speech features on recognition. To create ecologically valid conditions for voice recognition, the present study used voices in conversation in the target event and for the foils. The participants were particularly successful
Non-typeable Haemophilus influenzae (NTHi) is a common pathogen associated with diseases such as acute otitis media or exacerbations in patients with chronic obstructive pulmonary disease. The biofilm-forming capability substantially contributes to the persistence of NTHi. However, the regulation of biofilm formation is not completely understood. Quorum sensing regulated by autoinducer-2 produced
Development of long-lived humoral immunity is dependent on CXCR5-expressing T follicular helper (Tfh) cells, which develop concomitantly to effector Th cells that support cellular immunity. Conventional dendritic cells (cDCs) are critical APCs for initial priming of naive CD4(+) T cells but, importantly, also provide accessory signals that govern effector Th cell commitment. To define the accessor
"Zalmoxis" is a dramatic poem in which each character autonomously structures his own discursive lyric, expressing thus a variety of concepts over the spiritual foundation of the Dacians. The charm of each nuance in part relates in the last instance, the mode in which the author understands the proper structure of the actual dramatic perspective above the revolt of our non-Latin foundation. The ne
This paper explores how the Engineering Design process might balance conflicting constraints of technical product design and the social demands of users. Building on a generic 2D map for innovation in design from the author’s previous work, a prototype 3D Diamond Model is presented to help structure conversations between Designers and Users – or indeed any other group with apparently opposing aims
The present thesis analyzes the reform of congregational singing in Livonia and Estonia in the first half of the 19th century. In this process the writings on the aesthetics of the congregational singing of a German pastor Johann Leberecht Ehregott Punschel (1778–1849) active in Livonia, and a chorale book (1839) that he edited occupied the central place. Punschel’s activities are directly associa
