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Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) are potent vasodilators in animals and humans. PACAP infusion but not VIP infusion precipitates migraine attacks in migraine patients. The vascular effects of VIP and the two varieties of PACAP (PACAP-27 and PACAP-38) were investigated versus selective antagonists in segments of rat middle cerebral arter

We have recently shown in both herpesviruses and phages that packaged viral DNA creates a pressure of tens of atmospheres pushing against the interior capsid wall. For the first time, using differential scanning microcalorimetry, we directly measure the energy powering the release of pressurized DNA from the capsid. Furthermore, using a new calorimetric assay to accurately determine the temperatur

Taking the exhibition "Art in the Streets", which was shown at The Geffen Contemporary at the Museum of Contemporary Art, Los Angeles from 17 April to 8 August, 2011, as its main point of departure, the present article discusses street art's association with the institutions of the art world. "Art in the Streets" sparked a lot of debate before, while and after it took place. The article primarily

Optogenetic techniques provide powerful tools for bidirectional control of neuronal activity and investigating alterations occurring in excitability disorders, such as epilepsy. In particular, the possibility to specifically activate by light-determined interneuron populations expressing channelrhodopsin-2 provides an unprecedented opportunity of exploring their contribution to physiological and p

Stem Cell travel refers to patients with a variety of diseases and debilitating disorders who travel abroad to receive unproven stem cell treatments. Current academic research investigating how to combat stem cell travel has yet to offer a complete understanding of the link between patient hope and autonomy, and building or losing trust in medical authorities. To combat stem cell travel, understan

Popular Abstract in Swedish I världen beräknas det finnas cirka 38 miljoner blinda människor enligt Värdshälsoorganisationen (WHO). Av dessa är 1,5 miljon barn under 16 år. Blindhet definieras av WHO som bästa korrigerade synskärpa under 0,05 (man klarar således inte att läsa översta raden på en vanlig synprövningstavla på halva normalavståndet), detta med bästa glasögonkorrektion och med båda ögoKnowledge of the epidemiology of visual impairment in children forms one of the cornerstones in paediatric ophthalmology. To gain an overview of the situation in Sweden an epidemiological study was performed. Totally 2373 visually impaired children were found, giving an age-specific prevalence of 10,9/10 000. Childhood blindness (i.e. vision <0,05) was seen in 25%. Male/female ratio was 1,20. Addi

Piety and Modernity examines the dynamics fo religious reform from the point of view of piety and devotional life between 1780 and 1920 in Britain, Ireland, Scandinavia, Germany, and the Low Countries. The "long" nineteenth century saw the introduction of devotional organizations as a means of channeling popular religion. This era also witnessed the translation and publication of devotional books

The stereotypes about older adults and the incomplete picture that emerges when such persons are described in terms of properties and a characteristic derived from ageing is one motivation for defining the status of older users. The other key motivation is that the elderly are just one user-group among others so that the perspective on how technology is used may or may not tell us something about

Intestinal homeostasis and induction of systemic tolerance to fed Ags (i.e., oral tolerance) rely on the steady-state migration of small intestinal lamina propria dendritic cells (DCs) into draining mesenteric lymph nodes (MLN). The majority of these migratory DCs express the α integrin chain CD103, and in this study we demonstrate that the steady-state mobilization of CD103(+) DCs into the MLN is

Numerous β-defensins have been identified in birds and the potential use of these peptides as alternatives to antibiotics has been proposed, in particular to fight antibiotic-resistant and zoonotic bacterial species. Little is known about the mechanism of antibacterial activity of avian β-defensins (AvBDs), and the present work was carried out to obtain initial insights into the involvement of str

The aim of the present study was to evaluate acute kidney injury (AKI) with cystatin C following transcatheter aortic valve implantation (TAVI) and to assess the impact of postoperative AKI on outcome and late renal function.

The use of telehealthcare systems to promote independent living for elderly people is growing. The results presented in this article, derived from an initial user lab test of a telecare system—GiraffPlus—indicate that the crucial factor for adoption of telehealthcare systems is not usability but the system's ability to support autonomy in everyday life. Eleven users tested the usability and report

Membrane proteins are fairly refractory to digestion especially by trypsin, and less specific proteases, such as elastase and pepsin, are much more effective. However, database searching using nontryptic peptides is much less effective because of the lack of charge localization at the N and C termini and the absence of sequence specificity. We describe a method for N-terminal-specific labeling of

Oxygen toxicity is thought to be an important factor involved in development of bronchopulmonary dysplasia (BPD) in the very preterm infant. Glutathione (GSH) plays a major role in the antioxidant defense system in the preterm lung and there are theoretical implications that N-acetylcysteine (NAC) treatment could improve its function. The purpose of this study was to investigate whether NAC treatm

Data from measurements on the body burden Of (CS)-C-134, Cs-137 and K-40 in various Swedish populations between 1959 and 2001 has been compiled into a national database. The compilation is a co-operation between the Departments of Radiation Physics in Malmo and Goteborg, the National Radiation Protection Authority (SSI) and the Swedish Defense Research Agency (FOI). In a previous study the effecti