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Human papillomavirus 16 (HPV16) 5'-splice site SD226 and 3'-splice site SA409 are required for production of the HPV16 E7 mRNAs, whereas unspliced mRNAs produce E6 mRNAs. The E6 and E7 proteins are essential in the HPV16 replication cycle but are also the major HPV16 proteins required for induction and maintenance of malignancy caused by HPV16 infection. Thus, a balanced expression of unspliced an

In this study, two digital breast tomosynthesis (DBT) systems were evaluated: Siemens Mammomat Inspiration TOMO (Siemens Healthineers, Erlangen, Germany) and GE Senographe Pristina (GE, Buc, France). Along with differences such as angular range and detectors type, the systems use different reconstruction algorithms. One was available for the GE system, based on iterative reconstruction (IR). Two a

BACKGROUND: Problem behaviours are common among people with intellectual disabilities (ID), but psychometrically evaluated instruments for assessing such behaviours are scarce. The present study evaluated the psychometric properties of the Neuropsychiatric Inventory-Intellectual Disability (NPI-ID).METHOD: We assessed 108 residents with intellectual disabilities living in group-homes using the NPI

Purpose: This paper aims to unveil how sustainability is integrated into the courses/programmes of higher education institutions. The research question addressed is: how do academics representing different disciplines cooperate and engage in the work of integrating sustainability into their teaching programmes. Design/methodology/approach: This paper draws upon the notions of practise variation an

We give a significantly simplified proof of the exponential separation between regular and general resolution of Alekhnovich et al. (2007) as a consequence of a general theorem lifting proof depth to regular proof length in resolution. This simpler proof then allows us to strengthen the separation further, and to construct families of theoretically very easy benchmarks that are surprisingly hard f

A long line of research has studied the power of conflict- driven clause learning (CDCL) and how it compares to the resolution proof system in which it searches for proofs. It has been shown that CDCL can polynomially simulate resolution even with an adversarially chosen learning scheme as long as it is asserting. However, the simulation only works under the assumption that no learned clauses are

The aim of this study was to explore the influence of social ideologies on the doing, being, becoming, and belonging of Western employed professional women who are new mothers, after returning to work outside the home within the first 18 months after giving birth. Although occupational science has provided valuable insights into mothering occupations, it perpetuates an individualistic focus that o

Background: An occupational perspective in stroke prevention could support sustainable changes in habits and routines that could contribute to reduce modifiable risk factors. Aim: To explore engaging occupation in relation to risk for stroke by drawing on experiences from everyday life among persons with a heightened risk for stroke. Material and methods: Interviews from 14 persons with an increas

Examining communities in all their meanings, the paper locates User- Centred Design (UCD) in the amplified scope of approaches to Information Systems Design (ISD). Culture in communities is explained in structurational terms, in which human action and social structure (including ICT) interact to produce and reproduce the social patterning that both supports and constrains action. The widening of t

Arm lymphoedema and impaired shoulder mobility and muscle strength are well known side-effects to breast cancer treatment. The aim of this prospective study was to follow closely and describe the arm volume, range of motion of the shoulder and muscle strength of the shoulder and hand after breast cancer treatment in order to form a basis for further studies in the area including physiotherapy inte

Popular Abstract in Swedish Kroniskt obstruktiv lungsjukdom (KOL) är en allvarlig folksjukdom vars huvudsakliga orsak är tobaksrökning. Det är den enda av de viktigaste dödsorsakerna som ökar och år 2020 beräknas KOL utgöra den 4:e vanligaste dödsorsaken i världen. Flera studier har försökt att bestämma förekomsten (prevalensen) av KOL i befolkningen men tyvärr har de oftast använt olika metoder oBackground – Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. However, there is little information on the prevalence and particularly on the incidence of COPD. Also, apart from the importance of tobacco smoking and a1-antitrypsin deficiency, information on contributing risk factors for the development of COPD is limited. Hypotheses – 1. Spi

This paper studies the interdependence between R&D resources and standardization performance in development-related standardization settings under strong network effects. Standardization performance is viewed as the firm’s involvement in the change process of standards as a result of the business processes of standardization. We utilize a sample from the 3GPP change request database to study f

In this thesis, I critically explore the ways in which people consume extraordinary experiences and what this can tell us about contemporary society. My findings question the idea that extraordinary experiences are an escape from the demands of everyday life. I show instead that social (especially neoliberal) discourses discipline endurance runners and shape the ways in which they understand and a

Background: Research suggests that humans have the tendency to increase the valence of events when these are imagined to happen in the future, but to decrease the valence when the same events are imagined to happen in the past. This line of research, however, has mostly been conducted by asking participants to value imagined, yet probable, events. Our aim was to re-examine this time-valence asymme

Antimicrobial peptides (AMPs) are a diverse family of peptides that defend the mucosal surfaces of the oral cavity and other locations. Many AMPs have multiple functions and properties that influence aspects of innate defense and colonization by microorganisms. The human oral cavity is home to the second-most diverse microbiome, and the health of the mouth is influenced by the presence of these ba

MRI-based biophysical models are typically validated by comparison to ex-vivo histology of fixed tissue. The fixation process itself and the accompanied autolysis processes strongly modify tissue composition, and lead to MR signal changes, making the validation of biophysical models for in vivo MRI particularly challenging. To better understand the temporal evolution of the fixation process within

Background: In order to increase coverage in the organized cervical screening program, self-sampling with HPV analyses has been suggested. Objectives: The aim was to compare human papillomavirus (HPV) mRNA detection in vaginal and urine self-collected samples with clinician-taken cervical samples and the corresponding clinician-taken histological specimens. Study design: Self-collected vaginal, ur