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Background. Comatose survivors after cardiac arrest are treated with mild induced hypothermia and potent platelet- inhibiting drugs after coronary stenting. Previous studies have shown an increased incidence of stent thrombosis during clopidogrel and aspirin treatment in conjunction with induced hypothermia. The aim of this study was to investigate the in vitro effect of induced hypo- and hyperthe

Seed particles of elements or compounds which may or may not form alloys are now used extensively in promoting well-controlled nanowire growth. The technology has evolved following the well-known Vapour-Liquid-Solid (VLS) model which was developed over 40 years ago. This model indicates that a liquid alloy is formed from the seed particle and the growth precursor(s), resulting in crystal growth by

In this thesis, human behavior in rail tunnel fires is explored. Descriptive knowledge is presented related to the evacuation of passenger trains, and the subsequent tunnel evacuation to a safe location. More specifically, a theoretical framework that can aid the understanding of human behavior is identified, and its applicability to rail tunnels is demonstrated. In addition, new empirical data on

The HAMLET family of compounds (Human Alpha-lactalbumin Made Lethal to Tumours) was discovered during studies on the properties of human milk, and is a class of protein-lipid complexes having broad spectrum anti-cancer, and some specific anti-bacterial properties. The structure of HAMLET-like compounds consists of an aggregation of partially unfolded protein making up the majority of the compound'

The arterio-venous anastomoses (AVA) play a major role in the blood circulation in the peripheral body parts. In this work, the segmental bioheat model of Salloum et al. [1] is improved to accurately predict skin blood flow rate in the hands and fingers, and the local and overall human thermal responses in transient environments. The improvements in the model include: 1) extending the artery tree

Popular Abstract in Swedish Huntingtons sjukdom (HS) är en ärftlig hjärnsjukdom utan botemedel. Den orsakas av en mutation i en gen som kallas huntingtin. Den klassas som en s.k. neurodegenerativ sjukdom, där man ser en förlust av neuroner i delar av hjärnan som kontrollerar kroppsrörelser. Detta resulterar i dansliknande rörelser (chorea) och det är även därför som HS ibland kallas för danssjukanHuntington’s disease (HD) is a fatal, hereditary disease for which there is no cure. It is caused by a mutation in a gene called huntingtin. HD is a so-called neurodegenerative disease, where there is a loss of neurons in areas of the brain that control body movements. This results in uncontrolled dance-like movements (chorea). Traditionally, research on HD has focused round the brain and what is

The classical pathway of complement is crucial to the immune system, but it also contributes to inflammatory diseases when dys-regulated. Binding of the C1 complex to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activates C1s. C1s cleaves complement component C4 and then C2 to cause full activation of the system. The interaction between C1s and C4 inv

Permanent exposure to pathogens requires decisions toward tolerance or immunity as a prime task of dendritic cells. The molecular mechanisms preventing uncontrolled immune responses are not completely clear. We investigated the regulatory function of Ncf1, an organizing protein of NADPH oxidase, in the signaling cascade of Toll-like receptors. TLR9-stimulated spleen cells from both Ncf1-deficient

In this thesis the strategic behaviour of the three operators (Televerket/Telia, PTT Telecom and BT) on strong technological development and deregulation of the business during a period of fifteen years have been described, interpreted and analysed. Some thirty more operators have also been investigated in this respect - however not in depth. The strategic behaviour of the operators have been comp

The objective of this study was to describe environmental barriers and investigate the nature of accessibility problems in housing among single-living, very old people (N = 1,150) in urban regions in three European countries (Sweden, Germany, Latvia), in a one-year perspective. A specific feature of this study is the explicit conceptual differentiation between environmental barriers and accessibil

In wanting to pursue critically informed research, we highlight a steppingstone we use in our struggle answering the question ‘How do we recognize what to critically reflect upon?’. When we, as researchers, try to apply critical thinking we may find that our descriptions of our reasoning undermine the purpose for those descriptions. We perceive problems to flow from an entrapment of mind in the ‘f

In a joint project – Human Factors in ANS, HUFA - between the Swedish Civil Aviation Administration and Lund University the aim is to find out how a new team-based organization and the introduction of a new air traffic control system will affect safety culture and psychosocial working environment by changes in organizational climate, team climate and leadership. All in all, four studies will be co

This doctoral thesis examines the causes and effects of corporate disclosure practices. The thesis consists of four independent but related essays that collectively make up a country study for Sweden. The first essay aims to explain why some firms have a proactive disclosure strategy while others devote less resources and effort to disclosure and investor relations. Information about Swedish firms

Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by receptors of the TNF/nerve growth factor family, is lethal to mice in utero. To explore tissue-specific roles of this enzyme, we established its conditional knockout using the Cre/loxP recombination system. Consistent with its role in cell death induction, deletion of caspase-8 in hepatocytes protected

The purposes of this thesis are to provide a credible picture of the institutional transformation that I allege is taking place in the field of management education in Poland and to widen the field of application of institutional theory by applying it to the field of management education in Poland. In the study I conceptualise management education as an organisation field. The theoretical framewor

Moisture permeabilities (δv) of mature concrete and cement paste with water-cement ratio (w0/C) 0.4, 0.5 and 0.6 have been determined as functions of the relative humidity (RH). These δv can be used to calculate δv of the aggregates including the interfacial transition zone (ITZ). δv of granite has been preliminarily determined as a function of RH.

After infection with Borrelia burgdorferi, humans and mice under certain conditions develop arthritis. Initiation of inflammation is dependent on the migration of innate immune cells to the site of infection, controlled by interactions of a variety of adhesion molecules. In this study, we used the newly synthesized compound S18407, which is a prodrug of the active drug S16197, to analyze the funct

OBJECTIVE: The reason that only a minority of smokers develop chronic obstructive pulmonary disease (COPD) is still largely unknown. Glycosylation defects are involved in the pathological mechanisms in cystic fibrosis (CF), where chronic progressive obstructive lung disease dominates the clinical picture. Whether defects of protein glycosylation occur in COPD has not previously been examined. Incr

Synchronized activity is common during various physiological operations but can culminate in seizures and consequently in epilepsy in pathological hyperexcitable conditions in the brain. Many types of seizures are not possible to control and impose significant disability for patients with epilepsy. Such intractable epilepsy cases are often associated with degeneration of inhibitory interneurons in