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What’s bothering developers in code review?

The practice of code review is widely adopted in industry and hasbeen studied to an increasing degree in the research community.However, the developer experience of code review has receivedlimited attention. Here, we report on initial results from a mixed-method exploratory study of the developer experience.

Insights into automation of construction process using parallel-kinematic manipulators

This paper discusses challenges, experiences and lessons learned so far while transforming a masonry build system based mostly on manual labour into a robot automated build system. Our motivation for selection of this masonry process is to try out how robot automation could impact the architects in their design work by providing a tool to directly manipulate wall expression down to individual bric

Spider dung beetles : Coordinated cooperative transport without a predefined destination

Cooperative transport allows for the transportation of items too large for the capacity of a single individual. Beyond humans, it is regularly employed by ants and social spiders where two or more individuals, with more or less coordinated movements, transport food to a known destination. In contrast to this, pairs of male and female dung beetles successfully transport brood balls to a location un

Effects of dimple cone angles on heat transfer and pressure drop in a dimple jacketed heat exchanger

A Dimple Jacket Heat Exchanger (DJHE) is designed for the Chemical Post-Processing Integrated Equipment (CPPIE) to enhance the heat transfer performance during chemical reaction, crystallization and drying processes. In this paper, a 3D model of a DJHE is established. Dynamic variation of temperature inside the DJHE is compared with experimental data to validate the accuracy of the numerical metho

Carcinogen-DNA Adducts

Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA add

Fear of Graft Rejection after Heart Transplantation

PURPOSE: Perceived Threat of the Risk of Graft Rejection (PTRGR) is prominent in organ transplant recipients' lives. When asked about what they fear most, the commonest response is graft rejection. A reasonable assumption is that this perceived threat is also relevant for heart recipients and involves various psychological reactions, such as efforts to cope with the perceived threat. There are no

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better

In between resolution and cutting planes : A study of proof systems for pseudo-boolean SAT solving

We initiate a proof complexity theoretic study of subsystems of cutting planes (CP) modelling proof search in conflict-driven pseudo-Boolean (PB) solvers. These algorithms combine restrictions such as that addition of constraints should always cancel a variable and/or that so-called saturation is used instead of division. It is known that on CNF inputs cutting planes with cancelling addition and s

Digging in excavation diaries : digital re-assessment of stratigraphy in 3D GIS. The sanctuary of Ayia Irini, Cyprus

During the last years, numerous research projects focussed on re-examination of past excavations, giving birth to re-evaluation of their documentation and material or to new discoveries. The aim of this paper is to present an ongoing research on the digital re-assessment of the Ayia Irini sanctuary’s stratigraphy using 3D GIS, by corroborating published material with data extracted from the origin

The context of second foreign languages in Swedish secondary schools : Results of a questionnaire to school leaders

This article reports the results of a survey focusing on the educational context of second foreign languages (SFL) to which 147 Swedish secondary school leaders responded. The study aims to provide a picture of how SFLs like German, French and Spanish are organised in a representative selection of Swedish schools across the country. The results of the survey show that there are major differences b

Medieval Swedish Sermons on St. Olaf

Artikeln presenterar svensk senmedeltida helgonpredikan i allmänhet, några generella drag hos de ca 30 bevarade predikningarna om S:t Olof samt en mer ingående redogörelse för en av dessa.The contribution presents preserved medieval Nordic sermons on St Olaf, all of which are found in Latin manuscripts from the medieval library of Vadstena Abbey. After a brief discussion of what they sermons say about St Olaf and what sources the preachers may have used, the contents of one specific sermon are given in summary form.

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

Dysregulation of cytokines in the bone marrow microenvironment promotes acute myeloid leukemia cell growth. Due to the complexity and low throughput of in vivo stem-cell based assays, studying the role of cytokines in the bone marrow niche in a screening setting is challenging. Herein, we developed an ex vivo cytokine screen using 11 arrayed molecular barcodes, allowing for a competitive in vivo r

The interaction of erythromycin with theophylline

We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg X kg-1) over 1 h, followed by a maintenance infusion (0.5 mg X kg-1 X h-1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during th