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TARGET-seq: Linking single-cell transcriptomics of human dopaminergic neurons with their target specificity

Dopaminergic (DA) neurons exhibit significant diversity characterized by differences in morphology, anatomical location, axonal projection pattern, and selective vulnerability to disease. More recently, scRNAseq has been used to map DA neuron diversity at the level of gene expression. These studies have revealed a higher than expected molecular diversity in both mouse and human DA neurons. However

Female alternative reproductive tactics : diversity and drivers

It is often argued that anisogamy causes alternative reproductive tactics (ARTs) to be more common in males than females. We challenge this view by pointing out logical flaws in the argument. We then review recent work on the diversity of female ARTs, listing several understudied types such as solitary versus communal breeding and facultative parthenogenesis. We highlight an important difference b

A review of the Development Trend of Personalized learning Technologies and its Applications

Personalized learning tailors material and strategy to student requirements, interests, and goals in e-learning. These developments help educational institutions and other organizations to keep up with the fast pace of information technology, communications, and computing power. Studies show that self-adaptive learning and relevant learning information improve study efficiency. Compared to traditi

The Visceral Novel Reader and Novelized Medicine in Georgian Britain

The article introduces "the visceral novel reader" as a diachronic, context-sensitive mode of novelistic reception, in which fact and fiction overlap cognitively: the mental rehearsal of the activity of seeing, hearing, smelling, tasting, and touching while reading novels and, vice versa, the mental rehearsal of novels in the act of perceiving the real world. Located at the intersection of literat

Certified CNF Translations for Pseudo-Boolean Solving

The dramatic improvements in Boolean satisfiability (SAT) solving since the turn of the millennium have made it possible to leverage state-of-the-art conflict-driven clause learning (CDCL) solvers for many combinatorial problems in academia and industry, and the use of proof logging has played a crucial role in increasing the confidence that the results these solvers produce are correct. However,

A scoping review of online international student collaboration in occupational therapy education

Introduction: For occupational therapy students, international experiences and access to a global curriculum develops understanding of broad cultural and contextual determinants of health and wellbeing. International placements or study abroad opportunities are not possible for many students and many universities are developing alternative internationalisation opportunities. The aim of this review

Climate and soil properties drive soil organic and inorganic carbon patterns across a latitudinal gradient in southwestern China

PurposeDrylands account for 47.2% of land area and contain 15.5% of global carbon (C). However, the variation in organic and inorganic C stocks across latitudinal gradients in arid and semiarid shrubland ecosystems remains understudied, and we lack in-depth understanding of the main drivers of C variation at this spatial scale.MethodsHere, we sampled soils from 95 sites across a latitudinal gradie

Inactivation of RB1, CDKN2A and TP53 have distinct effects on genomic stability at side-by-side comparison in karyotypically normal cells

Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery. We performed a side-by-side comparison of how inactivation of each of these genes aff

“O, Zaria! You Have Become Just Like Karbala” : Race, Redemptive Suffering, and Affect in Shi‘i Devotional Liturgy

This article examines a Farsi-/Arabic-language Shi‘i ritual lamentation poem commemorating the Zaria Massacre of 2015, which saw hundreds of members of the Islamic Movement in Nigeria (IMN) led by Shaykh Ibrahim Zakzaky killed in clashes with the Nigerian army in the northern Nigerian city of Zaria, Kaduna Province. In addition to comparing the suffering of early-Muslim hagiographic figures with t

Imiquimod: ett nytt potentiellt läkemedel för COVID19?

BakgrundFör att tackla den rådande SARS-COV-2-pandemin har det ställts höga krav på en snabb utveckling och utvärdering av nya antivirala läkemedel. Bland några av de antivirala läkemedelskandidaterna finns imiquimod, en TLR7 agonist normalt administrerad för behandling av könsvårtor och basalcellscarcinom. Eftersom det har påvisats att imiquimod kan öka den antivirala responsen, är vår hypotes at

Terror remembered, terror forgotten : Stalinist, Nazi, and nationalist atrocities in Ukrainian 'national memory

In the 1930s and 1940s, Ukraine experienced political violence on an unprecedented scale. Political violence by the Soviet government and the German occupation authorities resulted in the death of millions, through starvation, deportations, and massacres, and left wounds which still have not fully healed. Independently of the Soviets and Nazis, mass political violence was carried out also by the O

Assessing the use of a portable time-geographic diary for detecting patterns of daily occupations

Background: A time-geographic diary approach is of interest in occupational therapy due to the inclusion of the diarist’s subjective experiences. There are several methods for detecting doing in time, but details needed for analysis are still lacking. The smartphone application POrtable Diary Data collector (PODD), a 24-hr diary based on the time-geographic diary has recently been introduced. Aim:

Kränkning och upprättelse. En replikation av en rättssociologisk enkätstudie

I rapporten presenteras ett rättssociologiskt forskningsprojekt som haft arbetstiteln ”Replika av en rättssociologisk undersökning om det allmänna rättsmedvetandet och brottsskadeersättningen”. Att projektet är en ”replika” innebär att syftet har varit att göra en uppföljning på ett ursprungligt forskningsprojekt som i det aktuella fallet utgörs av de enkätundersökningar som presterades i avhandli