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Fusion imaging in brain structure measurements on a fetus phantom, combining real-time ultrasound with magnetic resonance imaging

Objectives: To assess synchronisation of MRI and US in measuring foetus phantom head structures; inter-method, intra- and inter-observer differences on biparietal diameter (BPD), head diameter, anterio-posterior head diameter (HAP) and lateral ventricle structures (VS). Methods: Fusion Imaging (FI) has been performed by combining MRI and US simultaneously. Axial scans of 1.5 Tesla MRI on a foetus

Within-day energy deficiency and reproductive function in female endurance athletes

We aimed to estimate and compare within-day energy balance (WDEB) in athletes with eumenorrhea and menstrual dysfunction (MD) with similar 24-hour energy availability/energy balance (EA/EB). Furthermore, to investigate whether within-day energy deficiency is associated with resting metabolic rate (RMR), body-composition, S-cortisol, estradiol, T3 , and fasting blood glucose. We reanalyzed 7-day di

T Cell Activation Pathways : B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles

Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to the T cell, while the second signal is provided by interaction with costimulatory ligands on APC. CD2, LFA-1, and CD28 are the major costimulatory and adhesive molecules on T cells and bind to the LFA-3, ICAM

Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of “druggable” targets, and the access-limiting blood–retinal barrier (BRB) present major hurdles toward effective therapy development. Here, we address these challenges (i) by targeting cG

Cytogenetic nomenclature

This chapter elaborates on human chromosome nomenclature. It provides a brief summary of the most essential cytogenetic terminology related to the description of chromosome aberrations in neoplastic cells. The chapter outlines criteria for designation of regions and bands for chromosome nomenclature. Regions and bands are numbered consecutively from the centromere outward along each chromosome arm

Public opinion, party politics, and the welfare state

This chapter examines the long-run relationship between public opinion, party politics, and the welfare state. It argues that when large parties receive a clear signal concerning the median voter’s position on the welfare state, vote-seeking motivations dominate and the large parties in the party system converge on the position of the median voter. When the position of the median voter is more dif

Update on non-typeable Haemophilus influenzae-mediated disease and vaccine development

Introduction: Non-typeable Haemophilus influenzae (NTHi) has attracted more interest in recent years due to an increased prevalence of infections caused by the pathogen. This upsurge is at least partly ascribed to the introduction of the pneumococcal conjugated vaccines that has resulted in an aetiological shift in NTHi’s favor with respect to upper respiratory tract infections. Moreover, an incre

Sensory re-education

Repair of injured peripheral nerve trunks in the hand and upper extremity still represents one of the most challenging surgical constructive problems. In adults, discriminative sensory functions of the hand do not usually recover despite use of microsurgical repair techniques. A major reason for the imperfect outcome is the pronounced functional cortical reorganizations that occur after nerve inju

Health Literacy among patients with end-stage kidney disease and kidney transplant recipients

Main problem: Self-management is essential for patients both before and after kidney transplantation and requires an adequate level of health literacy (HL), that is the ability to comprehend and process health information. Low HL is associated with poor clinical outcome and an increased risk of death. In Europe, HL has been scarcely studied. The aim of this study was to investigate the levels of H

Green revolution

The Green Revolution in Asia from the early 1960s is defined as a process driven by governments in pursuit of self-sufficiency in food grains. The process was market-mediated and smallholder based and can be dated to the early 1960s with the Nobel Prize Laureate, Norman Borlaug’s research on high-yielding dwarf wheat in Mexico and later spread to rice and number of countries in South East and Sout

Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) and hnRNP A2 Inhibit Splicing to Human Papillomavirus 16 Splice Site SA409 through a UAG-Containing Sequence in the E7 Coding Region

Human papillomavirus 16 (HPV16) 5'-splice site SD226 and 3'-splice site SA409 are required for production of the HPV16 E7 mRNAs, whereas unspliced mRNAs produce E6 mRNAs. The E6 and E7 proteins are essential in the HPV16 replication cycle but are also the major HPV16 proteins required for induction and maintenance of malignancy caused by HPV16 infection. Thus, a balanced expression of unspliced an

Promote social participation among older persons by identifying physical challenges – An important aspect of preventive home visits

Introduction: Social participation can have a positive impact on health; however, physical challenges can be hindrances. During a preventive home visit a health professional (visitor) assesses different aspects of physical, mental and social health. However, there might be a challenge for the visitor to discover the interrelationship between physical factors that hinder social participation. There

Experiences and motives of retirement-aged workers during the first wave of COVID-19 in Slovenia : “This was the first time in 40 years that I really saw spring”

Choosing to continue working after retirement eligibility can attract both negative and positive sentiments from the general public. Studies examining the motivations of older workers have so far been conducted in times of relative social and economic stability. However, little is known about what it means for older workers to work during a lockdown or pandemic situation. The present longitudinal

Peak-to-valley ratios for three different HPGe detectors for the assessment of 137Cs deposition on the ground and the impact of the detector field-of-view

The peak-to-valley (PTV) method was investigated experimentally comparing PTV ratios for three HPGe detectors, with complementary Monte Carlo simulations of scatter in air for larger source-detector distances. The measured PTV ratios for 137Cs in air were similar for three different detectors for incident angles between 0 and 90°. The study indicated that the PTV method can differentiate between s

Viral Stimuli Trigger Exaggerated Thymic Stromal Lymphopoietin Expression by Chronic Obstructive Pulmonary Disease Epithelium: Role of Endosomal TLR3 and Cytosolic RIG-I-Like Helicases.

Background: Rhinovirus (RV)-induced chronic obstructive pulmonary disease (COPD) exacerbations exhibit TH(2)-like inflammation. We hypothesized that RV-infected bronchial epithelial cells (BEC) overproduce TH(2)-switching hub cytokine, thymic stromal lymphopoietin (TSLP) in COPD. Methods: Primary BEC from healthy (HBEC) and from COPD donors (COPD-BEC) were grown in 12-well plates, infected with RV