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Potent Intratype Neutralizing Activity Distinguishes Human Immunodeficiency Virus Type 2 (HIV-2) from HIV-1

HIV-2 has a lower pathogenicity and transmission rate than HIV-1. Neutralizing antibodies could be contributing to these observations. Here we explored side by side potency and breadth of intratype and intertype neutralizing activity (NAc) in plasma of 20 HIV-1, 20 HIV-2 and 11 dually HIV-1/2 (HIV-D) seropositive individuals from Guinea-Bissau, West Africa. Panels of primary isolates, five HIV-1 a

The relationship between the key elements of Donabedian's conceptual model within the field of assistive technology.

Previous research has suggested that there is a relationship between the three key components of Donabedian's conceptual model for quality assessments: structure of care, process, and outcome of care. That is, structure predicted both process and outcome of care, and better processes predict better functional outcomes and user satisfaction. The results in this study involving samples of Danish and

"Allt detta lovar jag" : löftesmomentet vid prästvigning, med särskild hänsyn till debatten om prästeden vid kyrkomötena 1868–1893 och dess senare följder

The purpose of this study is to describe and analyse changes in the pledge element of the ordination in the Church of Sweden. The transition in 1893 from a clerical oath to an affirmation will be particularly in focus and its causes and effects identified. My intention is thus to contribute to the history of the Swedish clerical oath, describing its complexity and multifarious range of meaning. In

Vigselrummet i Stockholms rådhus och det tidiga 1900-talets monumentalmåleri: historia, reception, historiografi

The competitions for the commission to decorate the Marriage Chamber in Stockholm City Law Courts (1912–1915) have become one of the most important events in the history of mural painting in Sweden. One of the proposals, by artist Isaac Grünewald, has become a major icon of early modernistic art in Sweden. Among the participants in the competition we find some of the most important introducers of

Regulation of T cell effector functions in the intestinal mucosa

T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. Naïve CD4+ and CD8+ T cells activation takes place in lymphoid organs after recognition of cognate antigen in the context of major hi

Mesoporous Silica Formed with Triblock Copolymers

Popular Abstract in Swedish En amfifil molekyl har två delar; en del som dras till olja och en del som dras till vatten. Dessa två delar benämns vanligen huvudgrupp respektive svans. Amfifila molekyler kallas ofta tensider (på engelska surfactants), och är de aktiva beståndsdelarna i bland annat tvättmedel och hårschampo. Amfifila molekyler i vattenlösning formar sig så att vattendelarna dras tillThe formation of highly ordered mesoporous silica materials, using PEO-PPO-PEO amphiphilic triblock copolymers (so-called Pluronics) as structure directing agents, has been studied. The materials are formed through the addition of a silica source to a polymer solution of low concentration (2.5 wt ) under acidic conditions. The products have BET surface areas of approximately 800 m2/g. The unit cel

Exponential Vector Field Tomography

In the exponential Radon transform in R2, the integrals of a scalar function f over lines, with exponential weight functions, are determined. We demonstrate how to define two different kinds of exponential Radon transforms for vector fields in R2 in a natural way. It is shown that having data from these transforms it is possible to reconstruct the vector field uniquely. The motivation for the stud

Transdiagnostic links of reward processing in obsessive-compulsive disorder and depression

ObjectivesTransdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in i

Meso-scale geometric modeling of cutting edges on vitrified bonded aluminum oxide grinding wheels for the multi-scale simulation of internal plunge grinding processes

Vitrified bonded aluminum oxide grinding wheels are widespread in use for many applications in grinding, such as internal plunge grinding. However, there are challenges when it comes to the measurement, analysis and (geometric) modeling of their topography, which is crucial to understand and model the influence of the topography on the process behavior. Methodological advances allow for the detail

Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis

Pseudomonas aeruginosa provokes a painful, sight-threatening corneal infection. It progresses rapidly and is difficult to treat. In this study, using a mouse model of P. aeruginosa keratitis, we demonstrate the importance of a carbohydrate-binding protein, galectin-8 (Gal-8), in regulation of the innate immune response. First, using two distinct strains of P. aeruginosa, we established that Gal-8−

New developments in virtual reality-assisted treatment of aggression in forensic settings: The case of VRAPT

Aggression is a known problem in individuals being cared for in forensic settings, yet the evidence base for its treatment is scarce. Virtual Reality (VR) has been proposed as a promising addition to interventions in forensic settings, as it may increase the motivation among participants, bridge the gap between real life, therapeutic and laboratory experiences, and increase the ecological validity

The serine protease HtrA plays a key role in heat-induced dispersal of pneumococcal biofilms

Streptococcus pneumoniae (the pneumococcus) colonizes the human nasopharynx by forming multicellular biofilms. Due to the high level of asymptomatic carriage, transition to infections, such as otitis media, pneumonia, sepsis, and meningitis, occurs often enough that the pneumococcus remains a major cause of disease and death globally. Virus infection and virus-induced responses, such as increased

A risk score model to predict incidental gallbladder cancer in patients scheduled for cholecystectomy

Background: Gallbladder cancer (GBC) has a poor prognosis. The aim was to develop and validate a preoperative risk score for incidental gallbladder cancer (IGBC) in patients scheduled for cholecystectomy. Methods: Data registered in the nationwide Swedish Registry for Gallstone Surgery (GallRiks) was analyzed, including the derivation cohort (n = 28915, 2007–2014) and the validation cohort (n = 78

Short-term effects of a computer-based nutritional nursing training program for inpatient hospital care

RATIONALE: This study aimed to explore whether a computer-based training in eating and nutrition for hospital nursing staff can influence the precision in nutritional treatment and care.METHOD: A pre-intervention and post-intervention study was conducted with a cross-sectional design at each time point. The settings were one intervention (IH) and two control hospitals (CH1 and CH2). Hospital inpat

Recruiting doctoral students

Recruiting doctoral students FACULTY OF SCIENCE | FACULTY OF ENGINEERING (LTH) 2 RECRUITING DOCTORAL STUDENTS Preface Contents Recruiting a new doctoral student is a strategically important decision and often a major investment for the organisation. A well-executed recruitment process increases the chances of a successful recruitment and reduces the risks of selection error. The needs of the organ

https://www.cgbkansli.lu.se/en/sites/cgbkansli.lu.se.en/files/recruiting_doctoral_students.pdf - 2026-05-29

Numerical Modeling for Subcutaneous Injection Pressure

To simulate subcutaneous injection pressure, numerical solvers are developed and subsequently used to train a predictive, data-driven surrogate model that delivers fast and reliable outputs. Different approaches are examined for solving a nonlinear partial differential equation that describes the pressure during subcutaneous injections over time and in a semi-infinite spatial domain. For the spati