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Efficacy and acceptability of cognitive-behavioral therapy and serotonin reuptake inhibitors for pediatric obsessive-compulsive disorder: a network meta-analysis

BackgroundCognitive-behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) are recommended treatments for pediatric obsessive-compulsive disorder (OCD), but their relative efficacy and acceptability have not been comprehensively examined. Further, it remains unclear whether the efficacy of in-person CBT is conserved when delivered in other formats, such as over telephone/webcam or as In

Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study

Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention perfor

Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.

ntrastriatal grafts of fetal ventral mesencephalic tissue, rich in dopaminergic neurons, can reverse symptoms in Parkinson's disease. For development of effective cell replacement therapy, other sources of dopaminergic neurons, e.g. derived from stem cells, are needed. However, the electrophysiological properties grafted cells need to have in order to induce substantial functional recovery are poo

IoT based microcontroller operated UV germicide system

With the rise of the COVID-19 pandemic across the globe, people have come to understand the requirement of sanitation. However, other than the personal hygiene, sanitization of all the appliances (like mobile phone, wristwatch, wallet, eye wear, etc.) has become very important. Therefore, the requirement of germicides is being increased to sanitize all the appliances. A few germicides comprise che

Caspase-8 serves both apoptotic and nonapoptotic roles

Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by receptors of the TNF/nerve growth factor family, is lethal to mice in utero. To explore tissue-specific roles of this enzyme, we established its conditional knockout using the Cre/loxP recombination system. Consistent with its role in cell death induction, deletion of caspase-8 in hepatocytes protected

A simple and sensitive method for lactose detection based on direct electron transfer between immobilised cellobiose dehydrogenase and screen-printed carbon electrodes

A rapid and simple approach of lactose analysis is proposed based on 3rd generation amperometric biosensors employing cellobiose dehydrogenase (CDH) from Trametes villosa or Phanerochaete sordida immobilised on screen-printed carbon electrodes (SPCEs). After optimisation of the working conditions of the biosensors - pH of the carrier buffer, flow rate and applied potential - the sensors were able

Spatio-temporal pattern mining on trajectory data using ARM

Preliminary mobile was considered to be a device to make human connections easier. But today the consumption of this device has been evolved to a platform for gaming, web surfing and GPS-enabled application capabilities. Embedding GPS in handheld devices, altered them to significant trajectory data gathering facilities. Raw GPS trajectory data is a series of points which contains hidden informatio

Role of CCL25/CCR9 in immune homeostasis and disease

Chemokines constitute a large family of low-molecular-weight proteins (∼10 kDa in size), recognized primarily for their role in directing leukocyte migration under both homeostatic and inflammatory settings. The chemokine CCL25 displays a unique and highly restricted expression pattern compared with other chemokine family members. In the steady state, CCL25 is expressed at high levels primarily in

The first single-stranded DNA virus targeting Pectobacterium belongs to the family Microviridae and demonstrates a broad host range to Pectobacterium brasiliense soft rot pathogens

UNLABELLED: Pectobacterium brasiliense ( Pbr) is known to be one of the most virulent Pectobacterium species and is generally widely distributed across the globe, especially known for causing soft rot in potato-tubers and black leg in potato-plants. Currently no treatment mechanism exists, and many studies have focused on alternative treatment approaches such as biocontrol agents. Several studie

Head acceleration in blind football players: A laboratory-based exploratory study

ObjectivesTo compare head acceleration between blind football players and non-disabled football players, and between anticipated and unanticipated conditions in blind football players.DesignLaboratory-based exploratory study.MethodsParticipants were ten football players (five blind football, five non-disabled; 80% female). Standardized head perturbations were applied in flexion, extension, lateral

Collaboration among emergency first responders at major incidents – an explorative focus group study

BackgroundIn the event of a major incident, collaboration between the ambulance service, fire brigade and police is common. Effective collaboration requires teamwork, with communication between the three organisations being crucial. Leadership functions should be integrated in a way that leverages organisation-specific capabilities, enabling interprofessional collaboration where diverse profession

Feeling safe by means of remote cardiac rhythm surveillance after open cardiac surgery : a mixed method pilot feasibility study

Background: This is one of the few European studies of self-management and self-monitoring during the initial two weeks following discharge after open cardiac surgery. Typical outcomes are mortality, morbidity, surgical complications and additional medical treatment. Equally important for enabling person-centred care are the patients’ perspective and main concerns. The aim was to explore feasibili

The association between ionized and total magnesium in critically ill patients : a prospective cohort study

Most clinical laboratories measure total magnesium (tMg) which includes both the ionized (iMg) and bound forms. Only the ionized component is biologically active, and it may be influenced by acid-base status, plasma protein concentrations and electrolyte disturbances, potentially altering how well tMg reflects iMg. This multicenter observational study evaluated the relationship between tMg and iMg

Team climate and safety culture in air traffic control

In a joint project – Human Factors in ANS, HUFA - between the Swedish Civil Aviation Administration and Lund University the aim is to find out how a new team-based organization and the introduction of a new air traffic control system will affect safety culture and psychosocial working environment by changes in organizational climate, team climate and leadership. All in all, four studies will be co

Från ägarmakt under ansvar till företagsledarmakt. En studie över maktförskjutningen hos tre svenska verkstadsaktiebolag

The dissertation is confined to the formal work of the boards of the parent companies as recorded in the approved minutes of meetings at Alfa Laval AB, Atlas Copco AB and Kockums Mekaniska Verkstads AB and is based on the Companies Law applying in Sweden since 1848. The study covers the time from the establishment of the joint stock company up to the ordinary general meeting of 1980 (1979 in the c

Spelet på fältet: relationen mellan ämnet idrott och hälsa i gymnasieskolan och idrott på fritiden

This study deals with physical education (PE) in secondary school. The purpose of the study is to analyze the relationship between PE in secondary schools and leisure time sports. Questions were directed towards discovering what PE teachers recognise as valuable in their teaching, and how physical education is related to factors that characterize the field of sports. The teaching practice of Physi

Extensions and Applications of Affine Shape

A central problem in computer vision is to reconstruct the three-dimensional structure of a scene from a set of two-dimensional images. Traditionally this is done by extracting a set of characteristic points in the scene and to compute a reconstruction of these points. In this thesis we propose a novel method that allows reconstruction of a wider class of objects, including curves and surfaces. As