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Functioning is a construct capturing how an individual’s engagement in everyday life emerges from the interaction between the individual and their environment. The World Health Organization’s International Classification of Functioning, Disability and Health (ICF) provides a biopsychosocial framework of functioning. Previously, the ICF was adapted for use in autism by developing Core Sets, a selec
Little is known about the fate and uptake of nanoplastics (NPs) in natural ecosystems, mainly due to analytical limitations in measuring NPs in complex environmental matrices. Our aim was to quantitatively assess the transport, fate and biological uptake of NPs in freshwater ecosystems by using replicated wetland mesocosms and gold-doped polystyrene nanoparticles. We showed that 97% of the NPs wer
Recent development of powder-bed additive manufacturing promises to enable the production of architectural structures that combine high resolution and articulation with economies of scale. These capabilities can potentially be used for functionally graded metamaterials as part of the building envelope and structure, paving the way for new functionalities and performances. However, designing such m
We derive analytical expressions to describe how light is frequency-shifted when interacting with ultrasound within scattering media, due to the modulation of the refractive index induced by the ultrasound pressure waves. The model is validated through Monte Carlo simulations, works for high ultrasound pressures, and allows for many simultaneous ultrasound waves or frequency components, which is i
Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the many phenomena that have been suggested to contribute to catalysis. In this work, we fo
Phosphate ester hydrolysis is fundamental to many life processes, and has been the topic of substantial experimental and computational research effort. However, even the simplest of phosphate esters can be hydrolyzed through multiple possible pathways that can be difficult to distinguish between, either experimentally, or computationally. Therefore, the mechanisms of both the enzymatic and non-enz
Targeted molecular dynamics was used to examine the mechanism of WPD loop closure in PTP1B, which is essential for the activity of the enzyme. Two important regions are identified: the R-loop (residues 113-118), which assists in substrate binding, and the S-loop (residues 198-209), which undergoes a conformational change that appears to be vital for the movement of the WPD loop. The S-loop is adja
Objective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.Design, setting and participants In this prospective observational study, 723 hospitalised patients who visited the emergency department at Skåne
This configurative review explores how nurturing and enacting a community-oriented praxis (COP) in teacher education can enhance teacher candidates’ preparedness for teaching roles whilst addressing some broader educational and societal concerns. Here, CoP is defined as practices that consider, connect with, and draw on local community strengths, needs, and aspirations for the good of individuals,
Context. Stars presently identified in the bulge spheroid are probably very old, and their abundances can be interpreted as due to the fast chemical enrichment of the early Galactic bulge. The abundances of the iron-peak elements are important tracers of nucleosynthesis processes, in particular oxygen burning, silicon burning, the weak s-process, and α-rich freeze-out. Aims. The aim of this work i
The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg2+ across cellular membranes, importing the cation to mitochondria in eukaryotes. Yet, the conducting and regulation mechanisms of permeation remain elusive, particularly for the eukaryotic Mrs2 members. Here, we report closed and open Mrs2 cryo-electron microscopy structures, accompanied by functional characterization. M
This paper examines the origins of formal education in colonial Zambia and its long-term consequences for educational attainment and gender inequality. Combining novel panel data on the location of missionary stations and mission school enrolment by gender and missionary society from 1924 to 1953 with contemporary data from the 1990 Zambian census, we ana-lyze the long-term effects of missionary e
Background: A large part of the Swedish population is exposed to higher levels of air pollution than the health-centered air quality guidelines recommended by the World Health Organization (WHO). Aim: The aim of the study was to illustrate the potential health benefits of cleaner air in Sweden by conducting a comprehensive health impact assessment, using a population sample of 100,000 individuals
Mars science fiction (SF) has interacted with Mars science ever since the advent of modern science, and has largely influenced public perceptions of the red planet and its exploration. In this chapter, it is argued that it has not only shaped numerous (mis)conceptions about the possibilities of indigenous Martian life, eventual human settlement and its challenges, but that it also has a large outr
Introduction: Little is known regarding the comparison of cardiovascular and kidney outcomes between lupus nephritis (LN) and other etiologies of chronic kidney disease (CKD). Methods: Using data from the Swedish Renal Registry (2006–2021), we compared long-term outcomes between patients with LN-CKD and patients with CKD due to primary glomerular diseases (PGD) and other CKD causes (Other-CKD, mai
This paper presents findings from a qualitative study on tourist vulnerability in wildfire scenarios considering the perspectives of tourist infrastructure owners/managers, fire and rescue service, municipality managers, researchers, and other emergency managers in Spain-France border regions. Through a thematic analysis of twenty survey responses, this study presents the critical factors influenc
The present study focuses on the computation of interfacial excess potential for the cohesive zones through which a brittle crack propagates in tungsten (W) twist grain boundaries (TGBs). Additionally, the influence of phosphorus (P) impurities is investigated. To this end, we have performed classical atomistic modeling of several ⟨110⟩ TGBs in their pristine and P-impurity segregated states. The
This study delves into the pressing issue of promoting sustainable tourist behavior in vulnerable heritage villages that are under threat from mass tourism. By employing the Theory of Planned Behavior, we conducted a survey of 406 domestic tourists in Abyaneh, Iran, to evaluate the influence of attitudes, perceived behavioral control, and subjective norms on environmentally responsible intentions.
