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We have recently generated 5'lambda5-huTAC mice, which express the human CD25 (huTAC) gene under the control of the 5'-flanking region of the mouse lambda5-gene. The huTAC-transgene was expressed in pre-B cells but neither in mature B cells nor in T cells of these mice. In this report we demonstrate that the transgene is also transiently expressed by adult CD25+ CD3-CD4-CD8- (triple negative, TN)
One purpose of the present study is to explore the stability of the pattern of health/work and sickness absence among middle-aged women over a period of three years. This study tested two hypotheses: (a) that enduringly healthy working women would perceive more valued occupational roles and higher well-being than long-term sick-listed women; (b) that high levels of well-being at baseline would pre
Popular Abstract in Swedish Polyomavirus är en familj av små DNA-virus som har onkogena egenskaper i försöksdjur i celler in vitro. De humana polyomavirusen BK virus (BKV) och JC virus (JCV) infekterar en stor del av befolkningen. Ungefär 70-80 % av vuxna är seropositiva, har antikroppar mot BKV och JCV. Primär infektion inträffar oftast under barndomen och är ofta subklinisk. Efter primära infektThe human polyomaviruses BKV and JCV are endemic and infect > 70% of population worldwide. Primary infections occur during childhood and are largely subclinical. Following primary infection, both viruses persist as latent infections in the kidneys and B lymphocytes. Under conditions of severe immunosuppression like leukaemia, organ transplantation and AIDS, the viruses can reactivate and cause dis
Popular Abstract in Swedish Läkaren har en viktig roll när det gäller att tillförsäkra människor vård på lika villkor. Mötet mellan läkaren och patienten präglas alltid av maktobalans. Studier världen över visar att invandrarpatienter är en sårbar grupp eftersom invandrare generellt har sämre tillgång till vård, sämre förutsättningar för hälsa och sämre hälsotillstånd jämfört med majoritetspopulatPhysician and patient do not meet as equals in the consultation. It is the responsibility of the physician to actively work for better communication in order to provide equitable health care for all individuals. Immigrant patients are a vulnerable group, shown in studies all over the world to have less access to care, fewer opportunities for health, and poorer health compared to majority populatio
Mucin-1 has proven to be a suitable target for antibody-based diagnosis and therapy of certain tumours, but no appropriate human antibody or antibody fragment displaying slow dissociation rate kinetics against this target is available. Since a rapid dissociation character prevents an antibody fragment from remaining at the site of the antigen, this fact may prevent the successful application of a
Background: The adoption of air conditioning (AC) is growing rapidly in developing countries across the world which puts a high burden on electricity distribution systems. This development is mostly driven by income growth and building design, but also due to increasing outdoor temperatures and to provide indoor thermal comfort. Current indoor thermal comfort standards are based on western clothin
Abnormalities in nuclear morphology are frequently observed in malignant tissues but the mechanisms behind these phenomena are still poorly understood. In this study, the relation between abnormal nuclear shape and chromosomal instability was explored in short-term tumor cell cultures. Mitotically unstable ring and dicentric chromosomes were identified by fluorescence in situ hybridization at meta
This case-control study based in Nordic serum banks evaluated the joint effects of infections with genital human papillomavirus (HPV) types, and Chlamydia trachomatis in the aetiology of cervical squamous cell carcinoma. Through a linkage with the cancer registries, 144 cases were identified and 420 controls matched to them. Exposure to past infections was defined by the presence of specific IgG a
Aim: The primary aims were to study risk factors for an ipsilateral breast event (IBE) after sector resection for ductal carcinoma in situ of the breast (DCIS) in a trial comparing adjuvant radiotherapy to no therapy and to assess predictive factors for response to radiotherapy Secondary aims were to analyse reproducibility of the histopathological evaluation and to estimate correctness of diagnos
The dentate gyrus (DG) is one of the few regions in the brain that continues to produce new neurons throughout adulthood. Seizures not only increase neurogenesis, but also lead to death of DG neurons. We investigated the relationship between cell death and neurogenesis following seizures in the DG of adult rats by blocking caspases, which are key components of apoptotic cell death. Multiple intrac
We study some fundamental computational geometry problems with the goal to exploit structure in input data that is given as a sequence C = (p(1), p(2), . . . ,p(n)) of points that are "almost sorted" in the sense that the polygonal chain they define has a possibly small number, k, of self-intersections, or the chain can be partitioned into a small number, X, of simple subchains. We give results th
Infestation of skin by the parasitic itch mite Sarcoptes scabiei afflicts 300 million people worldwide and there is a need for novel and efficient therapies. We have previously identified a multigene family of serine proteases comprising multiple catalytically inactive members (scabies mite-inactivated protease paralogs (SMIPPs)), which are secreted into the gut of S. scabiei. SMIPPs are located i
Popular Abstract in Swedish Vad får buddhister i dagens moderniserade Thailand att ge stora delar av sin inkomst till munkar? Och varför är det så viktigt att munkarna framstår som oegennyttiga och undviker fysisk kontakt med kvinnor? Frågorna behandlas utförligt i denna religionsantropologiska studie, baserad på en längre tids fältarbete i centrala, norra och nordöstra Thailand. Sociala och poliThis dissertation, based on 14 months of fieldwork carried out in central, northern and north-eastern Thailand, focuses on laypeople's demands on contemporary Thai Theravada sangha. In the aftermath of the economic breakdown in 1997, an intense discussion concerning the moral status of the sangha took place. The religious interests and demands clearly differ between different groups. What still se
The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six
75 RG2 glioma-carrying Fischer rats were treated by photon activation therapy (PAT) with monochromatic synchrotron radiation and stable thallium. Three groups were treated with thallium in combination with radiation at different energy; immediately below and above the thallium K-edge, and at 50 keV. Three control groups were given irradiation only, thallium only, or no treatment at all. For animal
Extreme weather events have the potential to cause serious harm and can contribute to displacement. Such events are expected to increase in frequency and/or intensity as a consequence of climate change. It is therefore of concern that there is widely considered to be a protection gap when affected individuals cross an international border. However, apart from a handful of cases in Australia and Ne
PURPOSE: To examine the cytokine profile of epithelial cells lining the human urinary tract with the aim of differentiating between the constitutive and disease-related cytokine production in these tissues.MATERIALS AND METHODS: Sections from the renal pelvis, ureter, bladder or urethra were obtained from 22 patients undergoing urinary tract surgery and were stained with monoclonal antibodies to i
The overall kinetics for manganese(II/III) catalyzed autoxidation of dissolved sulfur dioxide has been studied by UV-vis spectrophotometry. A free-radical mechanism has been proposed, and the rate constant for one of the key reactions between manganese(II) and peroxomonosulfate has been determined by pulse radiolysis. Previous literature on manganese catalyzed autoxidation of SO2(aq) has been thor
