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Glypicans are multifunctional cell surface proteoglycans involved in several important cellular signalling pathways. Glypican-1 (Gpc1) is the predominant heparan sulphate (HS) proteoglycan in the developing and adult human brain. The two N-linked glycans and the C-terminal domain that attaches the core protein to the cell membrane are not resolved in the Gpc1 crystal structure. Therefore we have s
In the present study a phase field model for high surface energy anisotropy is developed to model the morphologies of voids in UO2. In order to precisely account for the high anisotropy, an alternative forward-backward strategy based on a staggered grid with an averaged interface normal scheme is used in the numerical procedure. A variety of equilibrium void shapes are reproduced with respect to a
The CEBPA gene encodes a transcription factor protein that is crucial for granulocytic differentiation, regulation of myeloid gene expression and growth arrest. Mutations in one or both alleles of CEBPA are observed in about 10% of patients with acute myeloid leukemia (AML). Moreover, other genetic events associated with AML have been identified to deregulate C/EBP alpha expression and function at
The assumption of wide-sense-stationarity (WSS) and uncorrelated scattering (US) of wireless propagation channels is widespread for the design and analysis of wireless propagation channels. However, the assumption is only valid within a limited range. In this paper, we investigate the extension of this range not only in time (WSS), but also in frequency (US), for measured vehicular propagation cha
Understanding the molecular pathways that contribute to the development of tamoxifen resistance is a critical research priority as acquired tamoxifen resistance is the principal cause of poor prognosis and death of patients with originally good prognosis hormone-responsive breast tumors. In this report, we provide evidence that Med1, an important subunit of mediator coactivator complex, is spontan
The European common fisheries policy (CFP) advocates measures to sustain small-scale fisheries; hence, in the European Commission's proposal for a reformed CFP, these are exempted from a mandatory system with tradable fishing concessions. This opens up for management actions designed for small-scale fisheries, but also implies new management issues. This article provides insights into the topic ba
Due to the increasing cooling power and space limitation in vehicles, a new compact heat exchanger graphite foam heat exchanger is proposed for vehicle cooling application. The graphite foam has high thermal conductivity (the effective thermal conductivity is 40-150 W/m K) and low density (0.2-0.6 g/cm(3)), but it has high flow resistance which is a problem in heat exchanger applications. In order
Radiative interferences in the multi-parton shower is the building block of QCD jet physics in vacuum. The presence of a hot medium made of quarks and gluons is expected to alter this interference pattern. To study these effects, we derive the gluon emission spectrum off a color-correlated quark-antiquark pair (antenna) traversing a colored medium to first order in the medium density. The resultin
Introduction: The study aimed to investigate different aspects of cognition using the Cognitive Assessment Battery (CAB) in community-dwelling older adults aged 85 years. We also investigated the eventual influence of sex on the results and aimed to identify predictors for further cognitive decline after 1 year. Methods: CAB consists of 10 subtests covering the cognitive domains of speed and atten
The paper examines the ways in which states facilitate 'new enclosures' of natural resources, and the challenges of this as a strategy of development and environmental sustainability. We argue that enclosures introduce significant changes in property regimes, which redefine conditions for the access and control of land and forest, especially for tribal and indigenous communities. In this context,
Future operations of many fluid, thermal and power systems and their ability to store, transfer, and manage a variety of single or multiphase fluids in reduced gravity environment are of great importance. For many of these systems, cryogenic conditions will play an important role. Cryogenic vaporization, caused by heat leakage into the tank from the surrounding environment, is one of the main caus
The IDEM3 maturity model is a process improvement framework that can be used by an organisation to assess and improve their IT dependability management processes. The framework focuses on the coordination of IT management and safety management within an organisation. In this paper, an evaluation plan for the maturity model is presented to evaluate its applicability, assessment accuracy, and practi
PURPOSE: This paper has two purposes: one is to analyse how the policy of freedom of choice emerged and was formed in the Swedish health care discourse; the second is related to how free choice influences the discourse in health care and how subjects are formed within the field, i.e. what the language of choice in health care does. DESIGN/METHODOLOGY/APPROACH: The research strategy is inspired by
In the mid-nineteenth century, Karl Marx issued several critiques of political economy writings stressing the exclusive duality of states and the national economies. He argued that capitalism had characteristic features quite apart from those shaped by the idiosyncrasies of national economies. In the first part of this article, we critique the contemporary state-centered explanations for the indus
In this project different aqueous based solvent systems were investigated for the dissolution of steam exploded (STEX) dissolving pulps prior to a coagulation step for preparation of textile fibers. The pulp samples studied could, to a large degree, be dissolved in a NaOH/urea/thiourea system, but there are always residuals, irrespective of the conditions. The dissolution process appeared to be ki
In this study, nickel pattern electrodes were electrochemically investigated in a three-electrode setup, operating both with H-2/H2O and CO/CO2 atmospheres. Heating introduced structural differences in the nickel layer among the pattern electrodes, which appear to affect the electrode performance. Both dense and porous nickel pattern electrodes were formed by heating. Holes appeared in the nickel
We study the light scattering properties of double layer gratings (DLGs) made from Au on SiO2 substrates. It is found that surface plasmon polaritons (SPPs) can be excited in the DLGs for a separation of up to 150 nm between the two Au grating layers and the collective reflectance spectra exhibit a strong resonant peak and a closely lying dip as a result of the surface plasmon polariton excitation
