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The assembly of MHC class I molecules is regulated by a multi-protein complex in the endoplasmic reticules (ER) termed the loading complex. Tapasin is suggested to be one of the molecules forming this complex on the basis of its interaction with both the transporter associated with antigen processing (TAP) and MHC class I molecules. To address whether TAP is indispensable for the processing of the
In order to avoid environmental pollution and eliminate the need for using fertiliser, this study assessed for the first time the optimum performance of mature (in operation since 2011) vertical flow constructed wetlands in treating domestic wastewater (with and without hydrocarbon) and the subsequent recycling of the outflow to irrigate chillies (De Cayenne; Capsicum annuum (Linnaeus) Longum Grou
Introduction: An impact of maternal obesity on ultrasound dating of pregnancy at 11–14 gestational weeks is possible and was investigated. Material and methods: A prospective cohort study based on the Danish national population during a 4-year period in which we entered all mothers with singleton pregnancies who had a known last menstrual period (LMP), a recorded booking of body mass index (BMI),
During 1956 through 1987, 96,891 children have been screened for neonatal hip instability according to the tests of Ortolani and Barlow. In 1956 through 1972 only 4/58, 759 (0.07 permille) were missed, whereas during 1980 through 1987, 12/19, 398 (0.6 permille) were missed. This increase is not caused by any formal alteration of the screening programme. The screening has prevented a late diagnosis
Carriage or infection with penicillin-non-susceptible Streptococcus pneumoniae (PNSP) has been associated with antibiotic prescribing, socioeconomic factors, and attendance at day-care centres (DCCs). In the present study, linear regression was used to estimate the relation between these risk factors and the incidence of PNSP cases (non-susceptible defined as MIC >= 0.5 mu g/ml for penicillin) in
Intestinal alkaline sphingomyelinase (alk-SMase) digests sphingomyelin and the process may influence colonic tumorigenesis and cholesterol absorption. We recently identified the gene of human alk-SMase and cloned the cDNA. Cross-species screening of homology in GenBank found a hypothetical rat protein, XP_221184, with 491 amino acid residues, which shares 73% identity with human alk-SMase. Based o
A novel gel structure called the "plum-pudding" gel was described by us previously. I The gel was composed of randomly dispersed microgel particles ("plums") in a conventional hydrogel network. Depending on the preparation conditions, the microgels can be incorporated into the gel as expanded networks or dense collapsed globules. Where the microgel particles exist as collapsed globules, they have
Objective Atrial fibrillation (AF) is the most common arrhythmia and associated with increased morbidity and mortality. Its increasing prevalence calls for novel biomarkers to identify underlying pathophysiological mechanisms as well as patients at risk. Methods Plasma samples from 1694 individuals from the Swedish population-based Malmö Preventive Project (mean age 69.5 years; 29.3% female; mean
Several lines of evidence point to an increase in the activity of the terrestrial biosphere over recent decades, impacting the global net land carbon sink (NLS) and its control on the growth of atmospheric carbon dioxide (ca). Global terrestrial gross primary production (GPP)—the rate of carbon fixation by photosynthesis—is estimated to have risen by (31 ± 5)% since 1900, but the relative contribu
Popular Abstract in Swedish En fråga om liv och hälsa Livstillfredsställelse, personlighet och mortalitet i två äldre populationer Enligt en rapport från FN (2001) kan vi under de kommande 50 åren förvänta oss att andelen äldre över 60 år kommer att fördubblas. Ny och förbättrad teknik, medicinsk kunskap och behandling har utvecklats, vilket innebär att vi i dag överlever i större utsträckning dThe aims of the present thesis were to explore and describe elderly people’s morbidity and experience of symptoms in relation to life satisfaction, personality and mortality. (I, II and III) To learn from the individuals who have high life satisfaction in spite of the fact that they have concurrent medical diagnoses and conditions. (I and III) To reason how positive factors and strengths might hel
Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors.Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standa
This paper studies the role and function of corporate branding in organizational identity change, contributing to the increased scholarly interest in the organizing effects of branding, particularly corporate branding. Based on an ethnographic case study of corporate brand planning and implementation at a European telecommunications corporation, MGP, this paper demonstrates how corporate branding
En stund i solen gör oss både friskare och gladare. Men både för mycket och för lite sol kan orsaka allvarliga hälsoproblem. Vad som är lagom soltid för dig beror bland annat på dina gener, hur mycket pigment du har och var i världen du befinner dig. – Vi behöver hitta en balans. Jag tycker att vi ska fortsätta njuta av solen i lagom doser – det mår vi ofta bra av. Men den som är utomhus mycket be
https://www.medicin.lu.se/forskning/vad-forskar-du-om/darfor-gor-solen-oss-bade-friskare-och-sjukare - 2026-07-06
Occurring in 2015/16, the strong El Niño has been shown to significantly influence the pantropical carbon fluxes with multiple lines of evidence. However, a comprehensive understanding on the regional and vegetation-specific net ecosystem productivity (NEP) in response to this El Niño event and its recovery trajectories remain unclear. We revisited the controlling factors in the recovery of pantro
There has been a growing interest in how workers in high-carbon industries are impacted by low-carbon transitions and how such transitions can be implemented in a way that is just. This study explores the socio-cultural dimensions of these processes, focusing on the role of identity in shaping workers’ perceptions of low-carbon transitions and their ability to navigate change. It does so through a
With the need of renovation in the current timber structures, use of a cement based layer is a popular solution, which improves the structural integrity and increases the structural mass. In this paper, the use of a lightweight concrete with dowel type connections is investigated since such a combination can serve for both new and existing structures. Two types of dowel connections are experimenta
Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster, we present an expanded release of the community-generated population genomics resource Drosophila Evolution over Space and Time (DEST 2.0; https://dest.bio/). This release includes 530 high-quality pooled
Social services are adapting to an increasingly digital environment, with municipalities expectedto engage citizens through digital channels. This study investigates how clients seeking social as-sistance perceive and use digital tools as well as the challenges and opportunities that arise whenimplementing such technologies in line with public service values. The analysis draws on municipaldigitalSocial services are adapting to an increasingly digital environment, with municipalities expected to engage citizens through digital channels. This study investigates how clients seeking social assistance perceive and use digital tools as well as the challenges and opportunities that arise when implementing such technologies in line with public service values. The analysis draws on municipal digit
