Filetype
AIMS: Reduced expression of exocytotic genes is associated with functional defects in insulin exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development. MAFA and MAFB transcription factors regulate β-cell physiology, and their gene expression is reduced in T2D β cells. We investigate if loss of MAFA and MAFB in human β cells contributes to T2D progression by regul
The retinoblastoma gene product (pRb) is involved in both cell cycle regulation and cell differentiation. pRb may have dual functions during cell differentiation: partly by promoting a cell cycle brake at G(1) and also by interacting with tissue-specific transcription factors. We recently showed that pRb mediates differentiation of leukemic cell lines involving mechanisms other than the induction
I have analyzed the coverage of the 30th anniversary of the Roundtable Agreement and June elections in Polish news-papers of all political hues. Additionally, I scrutinized several official speeches held in connection with the commemorations. The goal of my inquiry has been to examine the uses of memory of 1989 in Polish politics of 2019 and highlight the strategic choices and constraints faced by
BACKGROUND: (Z,E)-9,12-tetradecadienyl acetate (ZETA, Z9,E12-14:OAc) is a major sex pheromone component for many stored-product moth species. This pheromone is used worldwide for mating disruption, detection, monitoring, and mass trapping in raw and processed food storage facilities. In this study, we demonstrate the biological production of ZETA pheromone by engineered yeast Saccharomyces cerevis
Maternal undernutrition can lead to protein-energy malnutrition, micronutrient deficiencies, or anemia during pregnancy or after birth. It remains a major problem, despite evidence-based maternal-nutrition interventions happening on ground. We conducted a scoping review to under-stand different strategies and delivery mechanisms to improve maternal nutrition, as well as how interventions have impr
BackgroundThis is the first nationwide segregation analysis that aimed to determine whether familial venous thromboembolism (VTE) is attributable to inheritance and/or shared environment, and the possible mode of inheritance.Methods and ResultsThe Swedish Multi‐Generation Register was linked to the Swedish patient register for the period 1964 to 2015. Three generational families of Swedish‐born in
The temporal dynamics of the spatial distribution of atomic hydrogen and oxygen in a lean methane-air flame, forced by a nanosecond repetitively pulsed discharge-induced plasma, are investigated via femtosecond two-photon absorption laser-induced fluorescence technique. Plasma luminescence that interferes with the fluorescence from H and O atoms was observed to decay completely within 15 ns, which
We previously reported that loss of mitochondrial transcription factor B1 (TFB1M) leads to mitochondrial dysfunction and is involved in the pathogenesis of type 2 diabetes (T2D). Whether defects in ribosomal processing impact mitochondrial function and could play a pathogenetic role in β-cells and T2D is not known. To this end, we explored expression and the functional role of dimethyladenosine tr
The skeletal responses to calcium depletion and repletion in rodents have been well characterized, but those in humans are poorly understood. The present study sought to evaluate the effects of short term dietary calcium depletion and repletion on biochemical markers of bone turnover in 15 young Caucasian women (age, 21-30 yr). The study contained 3 phases: 1) 5 days of a regular diet containing m
Background: The Supreme Court’s Dobbs v. Jackson Women’s Health Organization ruling was monumental for sexual and reproductive health and rights in the United States. This shifted the legislative power over the right to an abortion from federal to state government. Missouri’s post- Roe legislation banned abortion statewide. Health care providers (HCPs) are facing unique facilitators and barriers t
Megalencephalic leukoencephalopathy with subcortical cysts (MLC), is a congenital leukodystrophy with childhood onset. It is an extremely rare genetic disorder of the brain that affects less than 1 per 1,000,000 live births. Patients typically present macrocephaly during early childhood and later develop symptoms like decreased motor and cognitive functions, and epileptic seizures, all of which us
Product packaging has an impact on consumers' perception of the product and their purchasing decisions. In product packaging, colour is an important design factor. Therefore, this research paper will explore the impact of the colour of packaging on consumers' willingness to buy the product, as well as the consumers' perception of the products in the food industry.
One particular approach of behavioral economics has gained attention within environmental politics during the last decade. The idea of nudging (“gently pushing”) people in situations of decision-making towards the choice that in the long run is best for them as well as for the society and/or the environment seems to attract policy makers around the world. Many governments inside and outside the EU
This qualitative study explores whether antithesis, as a didactic rhetorical tool, may enhance the likelihood of understanding complex biology-related information. Research shows that students lack the ability of communicating expert knowledge to laymen since they do not understand subject matter well enough themselves due to scientific language. Hence, scientific language use should be studied in
This exploratory research intends to understand the driving forces within a regional innovation system (RIS), analysing the example of a rural area in Germany. It seeks to investigate how RIS help to create sustainable tourism products in rural areas. The theoretical framework focusses on the concepts of rural tourism, innovation and sustainability. Rural areas are often less developed than urban
Ett av de mest internationellt kritiserade besluten som Europeiska unionen tagit var då de 2008 beslutade att inkludera alla flyg till och från EU i Europeiska unionens handel med utsläppsrätter (EU ETS). Med betydelsen att flygbolagen skulle bli tvungna att handla med utsläppsrätter inte bara gällande de utsläpp som skedde inom Europeiska unionens luftrum utan också utanför. Beslutet resulterade
