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Amplification of 8p12-p11 is relatively common in breast cancer and several genes within the region have been suggested to affect breast tumor progression. The aim of the study was to map the amplified 8p12-p11 region in a large set of breast tumors in an effort to identify the genetic driver and to explore its impact on tumor progression and prognosis. Copy number alterations (CNAs) were mapped i
Background: Cerebral ischemia activates both the innate and the adaptive immune response, the latter being activated within days after the stroke onset and triggered by the recognition of foreign antigens. Methods: In this study we have investigated the phenotype of antigen presenting cells and the levels of associated major histocompatibility complex class II (MHC II) molecules in the postischemi
Unannounced evacuation experiments in a cinema theatre were analysed. The analysis focused on investigating if people are influenced by others during the initial phase of a fire evacuation. This type of influence is called social influence. Three separate behaviour types were identified and studied and the recognition and pre-movement time was measured. The results suggest that social influence is
The objective of this study was to show a method that combine non-invasive measurements of the relative diameter change, the radial and the longitudinal strain of the intima-media complex of arterial walls, respectively, to obtain total change in arterial wall volume for a segment of the common carotid artery. The method was evaluated in a limited trial in vivo, comprising five normotensive subjec
Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. The overall objective of this thesis was to develop a new assessment method of efficacy of biological therapy in clin
The birth, growth and maturity of industries, sectors and technologies have spurred the curiosity of researchers as well as managers and policy makers for a long time. Intriguingly, the emergence of a new industry is a complex process including many different actors and with a high level of uncertainty related to technology, institutions and markets facing the actors involved. Empirically this b
Textile exerts various environmental impacts throughout its life cycle. Prevention of textile waste is one means to reduce these impacts. This study seeks to map-out the flow of textile products in the three Nordic Countries – Denmark, Finland and Sweden – from the time they are put on the market until they are discarded. Based on the findings on the flows as well as on the perception of stakehold
The dissertation seeks to problematize the public debate which in recent years has made many people interested in and committed to the region. The empirical basis of the study is some of the regions of southern Sweden which have served as an important platform in the last thirty or forty years when the political and economic establishment has acted and argued in various contexts. The fundamental q
Although Emanuel Swedenborg (1688–1772) is commonly known for his spiritual philosophy, his early career was focused unnatural science. During this period, Swedenborg thought of the world was like a gigantic machine, following the laws of mechanics and geometry. This volume analyzes this mechanistic worldview from the cognitive perspective, by means of a study of the metaphors in Swedenborg’s text
This article seeks to explore how Christian self-understanding has changed as Jewish-Christian relations have enhanced and improved during the last half-century. To what extent are traditional Christological and soteriological models and motifs discussed, defined, redefined, refined or even refuted? Three issues are discussed: the need to (a) go beyond bipolarity (Judaism vis-à-vis Christianity et
This paper examines questionnaire-related issues of variations in the wording of questions and the objective accuracy of the response, in terms of three traffic-related phenomena (accident frequency, incident frequency, and speeding). ca. 900 survey respondents, living along four major arterial streets in Malmö, Sweden, estimated the occurrence of the phenomena in question. The dispatch consisted
Understanding spatial and temporal variability in the distribution of seabirds is fundamental for the conservation and management of marine ecosystems. In the absence of large-scale systematic survey data, the application of standard habitat modelling techniques to predict the at-sea distributions of seabirds at large spatial scales has been limited. In this study, we examine the utility of relati
Popular Abstract in Swedish En fråga om liv och hälsa Livstillfredsställelse, personlighet och mortalitet i två äldre populationer Enligt en rapport från FN (2001) kan vi under de kommande 50 åren förvänta oss att andelen äldre över 60 år kommer att fördubblas. Ny och förbättrad teknik, medicinsk kunskap och behandling har utvecklats, vilket innebär att vi i dag överlever i större utsträckning dThe aims of the present thesis were to explore and describe elderly people’s morbidity and experience of symptoms in relation to life satisfaction, personality and mortality. (I, II and III) To learn from the individuals who have high life satisfaction in spite of the fact that they have concurrent medical diagnoses and conditions. (I and III) To reason how positive factors and strengths might hel
