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Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of specific genes. CRISPR-dCas9-based tools offer this potential, yet β-cells are notoriously difficult to transfect, and efficient, non-viral delivery methods are lacking. Here, we developed nanopore-mediated electroporation to deliver a CRISPR interf
This thesis investigates the role of advanced atmospheric inversion techniques and ∆¹⁴CO₂ observations in improving the accuracy of regional CO₂ flux estimates across Europe. Accurate quantification of fossil fuel emissions and biospheric fluxes is essential for understanding regional carbon budgets and supporting climate policy. However, significant uncertainties persist due to limited observatio
The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor microenvironment, in which regulatory T cells (Treg) play a pivotal role in immunologic tolerance. In this study, we investigated the impact of complement facto
Nyhetsbrev från Akademikerföreningen Sveriges Ingenjörer vid Siemens Energy AB Kontakt: asi.se@siemens-energy.com Redaktörer: SvE, CH Nr: 06 2023-09-18 Revisionsutfall Årets lönerevision är nu sammanställd för ASI. I det bifogade underlaget presenteras ett histogram som visar hur revisionsutrymmet är fördelat. Medianlöneökningen för dom som ingår i revisionen hamnar på 2351:- vilket motsvarar en m
Bilaga 2 Saco-S-rådets styrelse Göteborgs universitet Verksamhetsberättelse 2021-2022 Saco-S rådet består av delegater utsedda av de medlemsförbund som finns representerade vid Göteborgs universitet. Rådet väljer vid sitt ordinarie årsmöte Saco-S styrelse (kallad styrelsen) och det är genom styrelsen rådet verkar. Inom styrelsen finns ett arbetsutskott (AU) bestående av ordförande, vice ordförande
Från hjärtats elektriska signaler till stavfel i arvsanlag – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Från hjärtats elektriska signaler till stavfel i arvsanlag 2021-12-10 Foto: iStock/Maryna-Ievdokimova Pyotr Platonov installerades som professor i kardiologi vid L
https://www.vetenskaphalsa.se/fran-hjartats-elektriska-signaler-till-stavfel-i-arvsanlag/ - 2026-07-19
Kvinnor med svår knäskada mår sämre än män – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Kvinnor med svår knäskada mår sämre än män 2010-05-21 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Kvinnor som drabbas av en allvarlig knäskada
https://www.vetenskaphalsa.se/kvinnor-med-svar-knaskada-mar-samre-an-man/ - 2026-07-19
Motion och belastning förbättrar ledbroskets kvalitet – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Motion och belastning förbättrar ledbroskets kvalitet 2013-08-21 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Artros är en kronisk sj
https://www.vetenskaphalsa.se/motion-och-belastning-forbattrar-ledbroskets-kvalitet/ - 2026-07-19
Olika mätrutiner vid födsel påverkar provresultat – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Olika mätrutiner vid födsel påverkar provresultat 2013-06-17 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Foto: Colourbox Olika rutiner f
https://www.vetenskaphalsa.se/olika-matrutiner-vid-fodsel-paverkar-provresultat/ - 2026-07-19
Remote sensing observations and artificial intelligence algorithms have emerged as key components for crop yield estimation at various scales during the past decades. However, the utilization of multi-source satellite data and machine learning for estimating aggregated crop yield at the regional level in Europe has been only scarcely explored. Our study aims to bridge this research gap by focusing
Uncertainty in our calculations of a system reveals the limits of our knowledge. This limitation makes model representations of the Earth system challenging and our predictions less reliable. However, despite appearing chaotic and non-linear, a system always follows a deterministic trajectory, which can often be expressed probabilistically. Building on this concept, this thesis applies data assimi
BackgroundHeart failure (HF) and arterial hypertension (AH) are strongly associated with obesity, with a linear relationship to increasing body mass index (BMI). However, some individuals with obesity do not exhibit signs of HF or AH.PurposeThis study aimed to compare, for the first time in a large population-based cohort, individuals with obesity who have normal left ventricular function and remo
Effective environmental policies for the tropics depend on accurate, representative scientific data. However, there is strong evidence from particular disciplines and regions that existing research is patchily distributed. Here, we show that poor representation of sampling and citation in some biomes and across key environmental gradients from all disciplines for the entire tropics may lead to fla
Africa is largely influenced by fires, which play an important ecological role influencing the distribution and structure of grassland, savanna and forest biomes. Here vegetation strongly interacts with climate and other environmental factors, such as herbivory and humans. Fire-enabled Dynamic Global Vegetation Models (DGVMs) display high uncertainty in predicting the distribution of current tropi
The 2018 drought was one of the worst European droughts of the twenty-first century in terms of its severity, extent and duration. The effects of the drought could be seen in a reduction in harvest yields in parts of Europe, as well as an unprecedented browning of vegetation in summer. Here, we quantify the effect of the drought on net ecosystem exchange (NEE) using five independent regional atmos
The terrestrial carbon cycle is an important component of the global carbon budget due to its large gross exchangefluxes with the atmosphere and their sensitivity to climate change. Terrestrial biosphere models showlarge uncertainties in simulating carbon fluxes, which impact global carbon budget assessments. The land surfacecarbon cycle is tightly controlled by soil moisture through plant physiol
Atmospheric inversions have been used for the past two decades to derive large-scale constraints on the sources and sinks of CO2 into the atmosphere. The development of dense in situ surface observation networks, such as ICOS in Europe, enables in theory inversions at a resolution close to the country scale in Europe. This has led to the development of many regional inversion systems capable of as
The nitrogen cycle and its effect on carbon uptake in the terrestrial biosphere is a recent progression in earth system models. As with any new component of a model, it is important to understand the behaviour, strengths, and limitations of the various process representations. Here we assess and compare five land surface models with nitrogen cycles that are used as the terrestrial components of so
