Filetype
Global warming is driving environmental change in the Arctic. However, our current understanding of this change varies strongly among different environmental disciplines and is limited by the number and distribution of field sampling locations. Here, we use a quantitative framework based on multivariate statistical modeling to present the current state of sampling across environmental disciplines
Biogeochemical models use meteorological forcing data derived with different approaches(e.g. based on interpolation or reanalysis of observation data or a hybrid hereof) to simulateecosystem processes such as gross primary productivity (GPP). This study assesses theimpact of different widely used climate datasets on simulated gross primary productivity andevaluates the suitability of them for repr
Background: Right ventricular (RV) systolic function is an important determinant of outcome in patients with pulmonary hypertension (PH). Conventional echocardiographic measures of RV are mainly based on longitudinal contractility. Recently, measurement of RV global longitudinal strain derived from multiple windows (RVGLS) has emerged as an option but has not been well evaluated. The aim of the pr
Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans.
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (htt) gene. Neuropathology is most severe in the striatum and cerebral cortex. As mutant htt is ubiquitously expressed, it has not been possible to establish clear structure-to-function relationships for the clinical aspects. In the present study, we have injected recombinant adeno-as
Tatrabergen, som ligger i västra delen av Karpaterna, har upplevt flera nedisningar under kvartärtiden. Avsättningarna i sluttningarna längs bergens södra sida har klassificerats som glacifluviala, baserat på geomorfologi, men har inte undersökts i detalj tidigare. Det här projektet fokuserar därför på att etablera avsättningshistoria och -processer samt avlagringarnas ålder i ett grustag i Biely The Tatra Mountains have had several glaciations during the Quaternary. The deposits located in the southern foothills were classified as glacifluvial, based on geomorphology, but its sediments have not been studied in detail. Therefore, this project focused on establishing the depositional history, processes, and age of the deposits in a gravel pit, located in the Biely Váh valley in these foothi
Background and Purpose-Evidence is emerging that inflammation plays a key role in the pathophysiology of ischemic stroke (IS). The aim of this study was to investigate whether genetic variation in the interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes (IL1A, IL1B, and IL1RN) is associated with IS and/or any etiologic subtype of IS. Methods-Twelve tagSNPs were anal
One of the largest sources of uncertainties in modelling of the future global climate is the response of the terrestrial carbon cycle. Studies have shown that it is likely that the extant land sink of carbon will weaken in a warming climate. Should this happen, a larger portion of the annual carbon dioxide emissions will remain in the atmosphere, and further increase global warming, which in turn
Syftet med denna studien är att bidra med kunskap om hur medarbetarna ser på sin användning av LinkedIn i förhållande till sin organisation. För att uppnå detta krävs en djupare förståelse för medarbetares användning och upplevelse av LinkedIn. Tidigare studier som undersöker LinkedIn har främst fokuserat på hur rekryterare kan använda plattformen och inte hur enskilda medarbetare använder plattfoThe purpose of this study is to contribute with knowledge about how employees perceive their LinkedIn usage in relation to their organization. To increase the awareness of how organizations can work strategically with LinkedIn the link between organizations and employees has been studied. Other studies examining LinkedIn have mostly had a recruiter perspective or have not considered users as emplo
The Global Land-Atmosphere Climate Experiment-Coupled Model Intercomparison Project phase 5 (GLACE-CMIP5) is a multimodel experiment investigating the impact of soil moisture-climate feedbacks in CMIP5 projections. We present here first GLACE-CMIP5 results based on five Earth System Models, focusing on impacts of projected changes in regional soil moisture dryness (mostly increases) on late 21st c
The aim of this thesis was to explore the impact of meniscal injury and meniscectomy on joint and muscle function, physical activity and perceived health in middle-age subjects and to evaluate the effect of a functional exercise program. Male and female post meniscectomy patients participated in Studies I-IV (n=45 in Studies I-III, n=99 in Study IV) and Study IV also included 94 controls. Outcome
The boreal biome exchanges large amounts of carbon (C) and greenhouse gases (GHGs) with the atmosphere and thus significantly affects the global climate. A managed boreal landscape consists of various sinks and sources of carbon dioxide (CO2), methane (CH4), and dissolved organic and inorganic carbon (DOC and DIC) across forests, mires, lakes, and streams. Due to the spatial heterogeneity, large u
The current study examined the role of visually perceived material properties in motor planning, where we analyzed the temporal and spatial components of motor movements during a seated reaching task. We recorded hand movements of 14 participants in three dimensions while they lifted and transported paper cups that differed in weight and glossiness. Kinematic- and spatial analysis revealed speed-a
Heart failure (HF) is a leading cause of death and disability globally. Heritable factors and the extent and pattern of myocardial fibrosis are important determinants of outcomes in patients with HF. In a genome-wide association study of mortality in HF, we recently identified a genetic polymorphism on chromosome 5q22 associated with HF mortality. Here, we sought to study the mechanisms by which t
Background: Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known about what type of cognitive impairment they are associated with. The aim was to examine the associations between different risk factors and future memory and attention/executive functions, and their interaction with APOE genotype. Methods: Participa
Popular Abstract in Swedish Stora framsteg har gjort det möjligt att, med dagens teknik, inte bara visualisera enskilda atomer, utan även utföra olika typer av operationer och manipulationer på atomskalan med stor precision rent experimentellt. Detta har möjliggjort tillverkning av komplexa nanostrukturer genom montering av komponenter av nanostorlek till större sammansatta system, vilket i sin tuNanowires constitute one of the fundamental building blocks in assembled nanodevices. Due to the high surface to volume ratio, the fraction of surface atoms is not negligible for nanosized elements. Because of the reduced coordination of surface atoms, the physical properties deviate from those of the bulk, which influences the overall physical properties of nanostructures. Consequently, this prov
The cardiac hormone atrial natriuretic peptide (ANP) is a central regulator of blood volume and a therapeutic target in hypertension and heart failure. Enhanced ANP activity in such conditions through inhibition of the degradative enzyme neprilysin has shown clinical efficacy but is complicated by consequences of simultaneous accumulation of a heterogeneous array of other hormones. Targets for spe
Background: Pectus excavatum (PE) is the most common congenital chest wall deformity. Most individuals with PE suffer from psychosocial problems, with low self-esteem and poor body image. Correctional surgery for PE is available, the most widely used is the Nuss procedure. The Nuss procedure has previously been reported to improve self-esteem, body image and health-related quality of life (HRQoL).
Background: Rupture of atherosclerotic plaques is the major cause of acute cardiovascular events. The biomarker PRO-C6 measuring Endotrophin, a matrikine of collagen type VI, may provide valuable information detecting subjects in need of intensified strategies for secondary prevention. Objective: In this study, we evaluate endotrophin in human atherosclerotic plaques and circulating levels of PRO-
