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Importance: Longitudinal tau positron emission tomography (PET) is a relevant outcome in clinical trials evaluating disease-modifying therapies in Alzheimer disease (AD). A key unanswered question is whether the use of participant-specific (individualized) regions of interest (ROIs) is superior to conventional approaches where the same ROI (group-level) is used for each participant. Objective: To
For 20 years, induced hypothermia and targeted temperature management have been recommended to mitigate brain injury and increase survival after cardiac arrest. On the basis of animal research and small clinical trials, the International Liaison Committee on Resuscitation strongly advocated hypothermia at 32-34 °C for 12-24 hours for comatose patients with out-of-hospital cardiac arrest with initi
Populärvetenskaplig sammanfattning: En sedimentsekvens från sjön Svartkälstjärn i Västerbotten provtogs för pollen- och sporanalys samt kolpartikelanalys. Sedimentens ålder bestämdes med 14C-dateringar och spår av radioisotopen 137Cs, som indikerar modern tid då de återspeglar provsprängningarna av kärnvapen under senare delen av 1900-talet. Dateringarna visar att sedimentationen i sjön började föA 2.1-m sediment sequence retrieved from Lake Svartkälstjärn, located at 260 m a.s.l. in the province of Västerbotten, Sweden, was subsampled for pollen and spore analysis, charcoal analysis, and influx calculations. The aim was to establish the local environmental development during the Holocene with focus on forest composition, fire frequency, soil erosion, aquatic production, and human impact.
The Auger-Doppler effect in the experimental spectra of HF and DF is presented. and the dynamics of ultra-fast dissociation in the core-excited state are discussed. The Doppler splitting of the atomic Auger peak is calculated and simulated using a classical model and a very good agreement is found between experiment and simulation. It is shown that the difference in photon energy relative to the r
Since 1990, Merck, Sharpe & Dohme, Sweden, has created fellowships for physicians embarking upon a career in clinical pharmacology at Swedish medical schools. The fellowship has provided full salary at the level of a resident in clinical medicine for an average period of 1-2 years. Between 1992 and 2004, 22 fellows representing all six medical schools were selected for a fellowship. Of these,
Popular Abstract in Swedish Enterostatin är en peptid (en liten del av ett protein) som bildas i magsäcken och tarmen under en måltid. I djurförsök då råttor behandlas med enterostatin har man funnit att både aptiten och kroppsvikten minskade. Den minskade aptiten gällde speciellt för fett. Enterostatin fungerar som en mättnadssignal för fett och kan därför vara viktig för att hindra uppkomsten avThe presence of procolipase and enterostatin in the rat gastrointestinal tract has been investigated. Procolipase was identified, using in situ hybridization and immunohistochemistry, in exocrine cells of the pancreas as well as in chief cells of the fundus region of the stomach. Enterostatin is the activation peptide of procolipase and it has been found to act as a satiety signal for fat. Using a
This article describes the development and the testing of the psychometric properties of an instrument, Profiles of Occupational Engagement among people with Schizophrenia, POES, with the aim of concluding data from time-use diaries and providing systematic description of status and progress regarding occupational engagement.
Zeaxanthin, a carotenoid in the xanthophyll cycle, has been suggested to play a role in the protection against photodestruction. We have studied the importance of the parameters involved in zeaxanthin formation by comparing spinach plants grown in low light (100 to 250 mol m-2 s-1) to plants transferred to high light (950 mol m-2 s-1). Different parameters were followed for a total of 11 days. Our
Background: Autism spectrum disorders (ASD) are a group of severe childhood neurodevelopmental disorders with still unknown etiology. One of the most frequently reported associations is the presence of recurrent de novo or inherited microdeletions and microduplications on chromosome 16p11.2. The analysis of rare variations of 8 candidate genes among the 27 genes located in this region suggested SE
Ibis paper deals with various methods of improved cooling of primary water in district heating (DH) substations and evaluates the benefit of an improved cooling from the perspective of the construction of an appropriate customer accounting method. The general benefit of an improved cooling is well-known: Less thermal stresses in pipelines, lowered heat and pumping losses and increased capacity in
Patented pharmaceuticals limit medicine access; Compulsory Licensing bridges the gap between Intellectual Property Rights and the Right to Health. The COVID-19 Pandemic sparked debates on medicine access and prompted legal revisions for improved systems. The European Union strives to enhance Intellectual Property Rights and Human Rights, yet current Compulsory Licensing has flaws that hinder medic
The role of food-producing sectors such as agriculture and aquaculture in the development process is debated and while some consider industrial production to be the answer, others suggest that small-scale production can also make contributions to poverty reduction and food security. This thesis aims to shed light on these relationships by performing quantitative analyses of the small-scale freshwa
Trichoderma are fungi that form symbiotic relationships with plant roots, representing an ecological topic for pest management. It offers a sustainable alternative to agrochemicals through biostimulation and biocontrol. However, the host plant needs to effectively manage a trade-off : using Trichoderma as a defense mechanism while not getting damaged by its cytotoxic compounds, like the antibiotic
This experimental study examined the effect of peer discussion and the effect of question format: free recall, follow-up and focused questions, on children's (age of 9-11 years) memory recall of a witnessed event. The children were randomly assigned in pairs that watched one of two perspectives of a film. Half of the pairs discussed the film and the other half of the pairs had a neutral discus
Alzheimer's disease (AD) is a neurodegenerative disease that often occurs in the elderly and is often accompanied by cognitive loss. Its main pathological features are the formation of amyloid-beta (Aβ) plaques and Tau tangles in the brain. Here, we used single-cell RNA sequencing (scRNA-seq) combined with computational cell–cell communication (CCC) analysis to systematically investigate trans
This psychometric study aimed to evaluate the psychometric properties of the Dysexecutive Questionnaire (DEX) following a cardiac event, and to examine the relationship between self- and informant-ratings. Approximately 7 months post-cardiac event, 196 participants and their informants (N = 179) completed the DEX. Reliability was assessed by confirmatory factor analysis and internal consistency esThis psychometric study aimed to evaluate the psychometric properties of the Dysexecutive Questionnaire (DEX) following a cardiac event, and to examine the relationship between self- and informant-ratings. Approximately 7 months post-cardiac event, 196 participants and their informants (N = 179) completed the DEX. Reliability was assessed by confirmatory factor analysis and internal consistency es
