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A new shifted zeroth-order Hamiltonian is presented, which will be used in second-order multiconfigurational perturbation theory (CASPT2). The new approximation corrects for the systematic error of the original formulation, which led to an relative overestimate of the correlation energy for open shell system, resulting in too small dissociation and excitation energies. Errors in the D, values for
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In this review we discuss the influence of chaperones on the general phenomena of folding as well as on the specific folding of an individual protein, MHC class I. MHC class I maturation is a highly sophisticated process in which the folding machinery of the endoplasmic reticulum (ER) is heavily involved. Understanding the MHC class I maturation per se is important since peptides loaded onto MHC c
Liquid solubility measurements were performed by immersion of poly(octyl)methylsiloxane (POMS) in dilute aqueous solutions of homologous series of aliphatic esters and alcohols with compound specific concentrations of 20, 40, 80 and 120 ppm. Measurements were performed at 20 °C with both single- and multi-compound mixtures and linear sorption isotherms were obtained. By fitting experimentally dete
A group of oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the doseresponse relations of different tu
Effects of polyamines on the spontaneous mechanical and electrical activity of guinea-pig intestinal smooth muscle were studied. Spermine and spermidine inhibited action potential generation and contractions, while putrescine had no effect. Single smooth muscle cells were isolated from the longitudinal muscle layer of the guinea-pig ileum. Whole-cell voltage-clamp experiments were carried out to i
Popular Abstract in Swedish De perifera nervstammarna i extremiteterna förmedlar signaler, dels till muskler, dels från känselkroppar som är belägna i bl a huden. Nervstammarna kan av olika orsaker utsättas för skador orsakade av vassa eller skärande föremål eller av olika typer av slitvåld. Nervskador ger ett mycket stort handikapp för den enskilde patienten som förlorar muskelfunktion och känselNerve injuries have a profound impact on individuals, suffering for the patients and induce cost for society. When dealing with severe nerve injuries that create a gap between nerve segments or when the injury is at the brachial plexus level, the clinical alternatives are limited. The brachial plexus model and its branches in the forelimb was evaluated as an experimental model for studies of nerve
The effect of UV radiation (half-band width 10 nm) in the wavelength range 248-340 nm on chlorophyll fluorescence from a thin layer of spinach thylakoid suspension was investigated. The parameter most sensitive to UV radiation was the rise time of variable fluorescence. The increase in rise time was proportional to UV photon fluence and was used for the determination of an action spectrum. The act
In this paper, we provide a new generalized construction method for highly nonlinear t-resilient functions, F: F-2(n) --> F-2(m). The construction is based on the use of linear error-correcting codes together with highly nonlinear multiple output functions. Given a linear [u, m, t + 1] code we show that it is possible to construct n-variable, m-output, t-resilient functions with very high nonlinea
Popular Abstract in SwedishGester betraktas ofta populärt som det mest typiska sättet för språkinlärare att lösa kommunikativa problem. Trots det har gester sällan studerats inom ramen för teorier som rör bruket eller inlärningen av andraspråk. Den här studien avser att redogöra för hur andraspråksinlärare använder spontana eller koverbala gester som kommunikationsstrategier. Gester klassificeras Gesture is always mentioned in descriptions of compensatory behaviour in second language discourse, yet it has never been adequately integrated into any theory of Communication Strategies (CSs). This study suggests a method for achieving such an integration. By combining a cognitive theory of speech-associated gestures with a process-oriented framework for CSs, gesture and speech can be seen as re
The purpose of this Phase II study was to evaluate if alum-formulated human recombinant GAD65 is safe and does not compromise beta cell function. The study was conducted as a randomized, double blind, placebo-controlled, dose-escalation clinical trial in a total of 47 Latent Autoimmune Diabetes in Adults (LADA) patients who received either placebo or 4, 20, 100, or 500 μg Diamyd subcutaneously at
The different roles played by small and large eddies in engine combustion were studied. Experiments compared natural gas combustion in a converted, single cylinder Volvo TD 102 engine and in a 125 mm cubical cell. Turbulence is used to enhance flame growth, ideally giving better efficiency and reduced cyclic variation. Both engine and test cell results showed that flame growth rate correlated best
Purpose: Antimuscarinic agents, which are used in to treat urgency and urge incontinence, have well-known effects on peripheral muscarinic receptors. However, some currently used drugs may have effects on muscarinic receptors in the brain and/or spinal cord involved in voiding control. We tested if muscarinic receptors within the central nervous system mediate a tonic excitatory influence on voidi
According to the polygyny threshold model, females are compensated for the cost of sharing a territory with other females by breeding in territories of higher quality than those of monogamously mated females. In the polygynous Great Reed Warbler (Acrocephalus arundinaceus), the variation in territory quality may be associated with nest site characteristics or food supply. In this study, we examine
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RATIONALE AND OBJECTIVES: Patients with a posterior indentation in the pharyngoesophageal segment (PES) are generally considered to have an abnormality of the cricopharyngeal muscle (CPM). In this study we determined the actual width of the PES and the pressure circumstances during swallowing within the pharynx and PES in such patients. METHODS: Simultaneous videofluoroscopy and solid state manome
Alpha-satellite sequences are found in the centromeric region of all human chromosomes and have been implicated in centromeric function. We describe the structure and behaviour of chromosomes containing amplified human alphoid DNA from chromosome 12, in an osteosarcoma cell line (OSA) and an atypical lipomatous tumour (ALT). In OSA, the amplified material was detected in one large marker chromosom
Post-shift and next-morning urine was sampled from workers exposed to hexahydrophtalic anhydride (HHPA), an epoxy hardener, sensitising at low exposure levels. Exposure levels of HHPA in air (gas chromatography, GC) in the range of 30-270 micrograms/m3 corresponded to urinary concentrations of 0.9-2.8 mumol hexahydrophthalic acid (HHP acid; GC-mass spectrometry)/mmol creatinine. In the morning sam
