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A substantial number of people who are exposed to vibrating hand-held tools develop vasospastic and sensorineural symptoms that may seriously affect the ability to work. Apart from the discomfort of the disease itself, this leads to socio-economic problems for the patients and high costs for the society. The diagnosis of the neurological symptoms is sometimes difficult and may be misinterpreted as

Introduction: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. Methods: We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prod

The Huang-Huai-Hai River Basin covers the major political and socioeconomic centers of China. Thus, flood protection and economic development by sustainable water supply are important. Due to this, it is imperative to study distribution and variation of precipitation characteristics under climate change. As hydrological observations are limited, scholars have done more research on daily, monthly,

This paper proposes a first-principle model of GPS receivers, that allows us to exploit the trade-off between battery consumption and positioning accuracy. We present the model and propose a GPS sampling strategy that uses both the current positioning confidence, and information about the GPS status. We complement the GPS sensor with internal measurement units and show how the given model exposes

Left ventricular assist devices (LVADs) have dramatically improved short-term outcomes among patients with advanced heart failure. While neurohormonal blockade (NHB) is the cornerstone of treatment for patients with heart failure with reduced ejection fraction, its effect after LVAD placement has not been established. We reviewed medical records of 307 patients who underwent primary LVAD implantat

Patients with biventricular assist devices (BIVAD) are severely critically ill compared with patients who receive left ventricular assist device (LVAD) support alone and portend a significant risk for greater adverse events including pump thrombosis (PT). Current approaches to treat PT are limited to LVAD with variable outcomes depending on the management strategy implemented. Moreover the managem

Road Agencies set quantitative targets and adopt related road safety strategies within the priorities and the available resources at the time of an economic crisis. In this framework, benefit-cost analyses (BCA) are carried out to support the decision making process and alternative measures are ranked according to their expected benefit and benefit-cost ratio calculated using a Safety Performance

In this paper, a multi-scale model is used to assess the multiple mineral precipitation potential in a full-scale anaerobic granular sludge system. Reactor behaviour is analysed under different operational conditions (addition/no addition of reject water from dewatering of lime-stabilized biomass) and periods of time (short/long term). Model predictions suggest that a higher contribution of reject

In Alzheimer's disease (AD), an association was found between autonomic dysfunction and frontal hypoperfusion in brain during orthostatic testing. To ascertain whether frontal hypoperfusion is dependent on longitudinal effects of hemodynamic disturbances, or contributes to them, we studied the relationship between the presence of orthostatic hypotension (OH) and resting cerebral blood flow (CBF) i

Thirteen women with senile dementia of Alzheimer’s type (SDAT) according to NINCDS-ADRDA and 21 age-matched control women, aged 75-96 years, were investigated with clinical examination, dementia rating scales and single photon emission computed tomography (SPECT) using99mTc-hexamethylpropyleneamine oxime (HM-PAO) as a tracer of regional cortical blood flow. The aim was to study whether typical SPE

Cleaning coils can be an efficient way to reduce the need for reparations and maintain the functionality of a ventilation system. This study builds upon existing knowledge concerning the contamination of heat exchangers. Through field measurements on coils and heat-recovery units, a laboratory experiment on a coil, and a generic calculation example, this study determines the impact of sustained co

PurposeUganda is one of many African countries struggling to develop adequate healthcare, particularly in regard to local treatment and access to drugs. The purpose of this paper is to contribute to the understanding of how reducing supply-chain complexity can improve health in developing countries. Design/methodology/approachThis study and evaluation included 50 interviews and 27 site visits of t

A model was developed which describes simultaneous reaction and internal diffusion for kinetically controlled, immobilized α-chymotrypsin-catalyzed, oligopeptide synthesis in acetonitrile medium. The model combines the equations that describe the intrinsic kinetics of four different reactions and the physical characteristics of three different support materials, as determined experimentally, to pr

Polyacrylamide beads and celite were used for immobilization of bovine α-chymotrypsin and lipase B from Candida antarctica. Polyacrylamides with a high degree of cross-linking afforded high catalytic rates when used as immobilization matrices. Derivatization of the polymer with carboxyl and tertiary amino groups prior to immobilization caused no significant changes in α-chymotrypsin behavior. The