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Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Although some heterogeneities have been used in in-silico human atrial modeling studies, they have not
We show how radiological images of both single and multi material samples can be simulated using the Monte Carlo simulation tool McXtrace and how these images can be used to make a three dimensional reconstruction. Good numerical agreement between the X-ray attenuation coefficient in experimental and simulated data can be obtained, which allows us to use simulated projections in the linearisation
The loss of native riparian vegetation and its replacement with non-native species or grazing land for agriculture is a worldwide phenomenon, but one that is prevalent in Europe, reflecting the heavily-modified nature of the continent's landscape. The consequences of these riparian alterations for freshwater ecosystems remain largely unknown, largely because bioassessment has traditionally focused
A numerical model was developed of beach morphological evolution in the vicinity of coastal structures. The model includes five sub-models for random wave transformation, surface roller development, nearshore wave-induced currents, sediment transport, and morphological evolution. The model was validated using high-quality data sets obtained during experiments with a T-head groin and a detached bre
Colorectal cancer (CRC) is one of the most common forms of cancer worldwide, with an annual incidence of more than 1 million cases. Despite advancements in the management of CRC, mortality remains high. Accumulating evidence indicates that CRC is a heterogeneous disease, which affects outcome beyond what can be predicted by disease stage and other conventional prognostic factors. Thus, there is a
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that, if not treated, will progress into blast crisis (BC) of either myeloid or B lymphoid phenotype. The BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase, is thought to be sufficient to cause chronic phase (CP) CML, whereas additional genetic lesions are needed for progression into CML BC. To generate a humanize
Background: Chlamydia trachomatis is the most common cause of sexually transmitted infections globally and the leading cause of preventable blindness in the developing world. There are two biovariants of C trachomatis: 'trachoma', causing ocular and genital tract infections, and the invasive 'lymphogranuloma venereum' strains. Recently, a new variant of the genital tract C trachomatis emerged in S
Objective. To investigate alterations of tumor necrosis factor (TNF)-, interleukin (IL)-6, the Notch/Jagged signaling pathway, and hepatocyte proliferation, and their correlation in rats subjected to partial hepatectomy. Material and methods. Blood and liver tissues were sampled immediately (0), 5, 15, 30, 60, 180, 360, and 720 min, and 1, 2, 4, and 7 days after partial (70%) hepatectomy to measur
Global warming will bring about changes in surface energy balance of Arctic ecosystems, which will have implications for ecosystem structure and functioning, as well as for climate system feedback mechanisms. In this study, we present a unique, long-term (2000-2010) record of summer-time energy balance components (net radiation, R-n; sensible heat flux, H; latent heat flux, LE; and soil heat flux,
The objective of this paper is to compare predictions with two hand-calculation methods with data from a small-scale two-room compartment fire experiment including 52 individual tests. The first method is based on two previously presented empirical models, and the second method consists of several calculation steps in order to solve a simple energy balance. The second method is based on the conser
The production of K*(892)(0) and phi(1020) in pp collisions at root s = 7 TeV was measured by the ALICE experiment at the LHC. The yields and the transverse momentum spectra d(2)N/dydp(T) at midrapidity vertical bar y vertical bar < 0.5 in the range 0 < p(T) < 6 GeV/c for K*(892)(0) and 0.4 < p(T) < 6 GeV/c for phi(1020) are reported and compared to model predictions. Using the yield of pions, kao
The PHENIX Collaboration at the Relativistic Heavy Ion Collider has measured open-heavy-flavor production in Cu + Cu collisions at v root s(NN) = 200 GeV through the measurement of electrons at midrapidity that originate from semileptonic decays of charm and bottom hadrons. In peripheral Cu + Cu collisions an enhanced production of electrons is observed relative to p + p collisions scaled by the n
In this paper, a mathematical model is presented by which the cutting forces in gear form milling process are predicted using the mechanistic approach. To use this approach, a detailed description of the chip geometry is needed. Eccentricity and run-out tool errors are considered, which is of great importance as the chip thickness will by these errors vary for the subsequent cuts. The chip geometr
Standard No. EN 15831:2004 provides 2 methods of calculating insulation: parallel and serial. The parallel method is similar to the global one defined in Standard No. ISO 9920:2007. Standards No. EN 342:2004, EN 14058:2004 and EN 13537:2002 refer to the methods defined in Standard No. EN ISO 15831:2004 for testing cold protective clothing or equipment. However, it is necessary to consider several
Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological activities of ABA several studies have identified shape, crystallinity and size as critical factors affecting their adjuvanticity. In spite of recent advances, the fate of ABA following their administration remains unclear. Few if any s
The blood parasite diversity was studied in paddyfield warblers (Acrocephalus agricola) breeding in NE Bulgaria, SW Russia and S. Kazakhstan. Nine cytochrome b gene lineages were recorded, 4 belonging to Haemoproteus spp. and 5 to Plasmodium spp. The overall prevalence of haemosporidians was 33.3%. The composition of parasites varied geographically, with six lineages recorded in Russia, five linea
The expansion in the supply of energy services over the last couple of centuries has reduced the apparent importance of energy in economic growth despite energy being an essential production input. We demonstrate this by developing a simple extension of the Solow growth model, which we use to investigate 200 years of Swedish data. We find that the elasticity of substitution between a capital-labor
Intermarriage with natives is a key indicator of immigrant integration. This article studies intermarriage for 138 immigrant groups in Sweden, using longitudinal individual level data. It shows great variation in marriage patterns across immigrant populations, ranging from over 70 percent endogamy in some immigrants groups to below 5 percent in other groups. Although part of this variation is expl
