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Background Pancreatic enzyme replacement therapy (PERT) prevents malnutrition in people with exocrine pancreatic insufficiency, including those with cystic fibrosis (CF). We developed a lipase that is stable against proteolysis and at the pH of the fed stomach, so it can be taken during a meal to promote mixing of enzyme and substrate. We designed a dose-ranging study of ANG003, a microbial PERT c
Humans have a propensity for rhythmicity, notably expressed in the domains of lan-guage and music. It is expressed through the abilities to produce and perceive rhyth-mic signals, as well as entrainment, which is the ability to synchronise movements inrelation to external rhythmic stimuli (e.g., dancing). However, it remains unclear asto how, why or when this rhythmic propensity evolved.A comparat
Sexual selection often leads to sexual conflict via pre-copulatory (harassment) and/or copulatory (traumatic insemination) male harm to females, impacting population growth, adaptation and evolutionary rescue. Male harm mechanisms are diverse and taxonomically widespread, but we largely ignore what ecological factors modulate their diversification. Here, we conducted experimental evolution under l
Context. The majority of Galactic globular star clusters (GCs) have been reported to contain at least two populations of stars (hereafter, we use P1 for the primordial and P2 for the chemically enriched population). Recent observational studies found that dynamically old GCs have P1 and P2 spatially mixed due to relaxation processes. However, in dynamically young GCs, where P2 is expected to be mo
This chapter examines the enduring presence of pre-Christian, Pagan religious elements in Baltic folklore—the related but distinct folk traditions of Lithuania and Latvia—and the purposes these remnants of Baltic Paganism serve as expressions of ethnic and/or national identity. Particular attention is paid to a genre of folk songs known as dainasin Latvia and dainos in Lithuania, solstice celebrat
Housing is crucial for people to flourish, as it is more than shelter and physical infrastructure. The conversation discusses trajectories and ‘variegations’ in universal, decommodified, non-profit housing provision in Scandinavian countries, focusing on Sweden (allmännyttan) and Denmark (almen). It explores how Sweden’s municipal rental housing was transformed by neoliberal market fundamentalism,
The fall of 2022, with the election success of a coalition of right wing and ethnoracist parties, marks the transition from a racialized to a racist state in Sweden. We analyse the discourses of three welfare projects in Swedish racial capitalism - Keynesian, Neoliberal, and ethnoracist - in relation to safety/security.Methodologically, we use CDA analysing elite institutional texts (party documen
Early kidney function decline may be associated with reduced filtration of middle-sized molecules, currently defined as selective glomerular hypofiltration syndrome (SGHS), and driven by the accumulation of atherosclerosis-promoting proteins. We aimed to investigate whether SGHS and other markers of kidney function are associated with subclinical atherosclerosis as evaluated by intima-media thickn
Aims Academic journals are essential for advancing knowledge, yet gender disparities in orthopaedic authorship persist. While most previous studies focus authorship trends on mainly North American journals, this study analyzes gender distribution among primary and senior authors, along with the geographical origins of articles, in three orthopaedic journals based in Europe and North America. Metho
We present a novel unsupervised framework, which links continuous visual features and symbolic textual descriptions of manipulation activity videos. First, we extract the semantic representation of visually observed manipulations by applying a bottom-up approach to the continuous image streams. We then employ a rule-based reasoning to link visual and linguistic inputs. The proposed framework allow
Genetic variation in immune genes is an important component of genetic diversity. The genes in the major histocompatibility complex (MHC) provide an excellent model system for studying the mechanisms that generate and maintain genetic diversity in natural populations. While both demographic factors and pathogen-mediated selection processes contribute to the extreme diversity observed in the MHC sy
Purpose: Humoral immunity proteins—immunoglobulins, complement proteins, and antimicrobial peptides—have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections. Methods: We performed a systematic review and meta-analysis evaluat
Hydrodeoxygenation (HDO) is a catalytic process applied for the reduction of oxygen levels in hydrocarbons from bio-derived feedstock as part of the processing into renewable fuel. The MoS2-based hydrotreating catalysts, currently being applied for the HDO reaction, are exposed to a complex environment consisting of O-rich hydrocarbons and water, which adversely impacts the state and stability of
Background: Posterior fossa tumours (PFT) are the most common childhood brain tumours, and children treated for these tumours are at increased risk of persistent speech, language and/or communication difficulties. Such difficulties have often been described in association with the postoperative complication cerebellar mutism syndrome (CMS), but can also occur in children without a period of mutism
Weight stigma is a social justice issue that can lead to weight-based discrimination and mistreatment. In pregnancy, emerging evidence has highlighted that weight stigma predominantly affects individuals who have larger bodies and is associated with postpartum depression and avoidance of healthcare. Racial and ethnic background will influence perceptions of, and responses to, weight stigma and the
This thesis studies reproducing kernels that are realized as pointwise quotients of two other kernels, including far-reaching generalizations of de Branges–Rovnyak spaces. In the first article, we study reproducing kernels arisingfrom the well-known multiplier criterion. They are intimately connected to certain operator inequalities, such asthe famous inequality of Shimorin in sub-Bergman spaces,
Fire has shaped terrestrial ecosystems for hundreds of millions of years. Human activities dramatically shift natural fire regimes, leading to adverse conservation impacts that are projected to increase in severity. Many animals appear ill-equipped to face these drastic changes, and they may be unable to adapt rapidly enough. In contrast, behavioural plasticity could offer a faster solution to ach
