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Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Cyclooxygenase-2, which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a key enzym
Introduction: The constant challenge to restore sensory feedback in prosthetic hands has provided several research solutions, but virtually none has reached clinical fruition. A prosthetic hand with sensory feedback that closely imitates an intact hand and provides a natural feeling may induce the prosthetic hand to be included in the body image and also reinforces the control of the prosthesis. A
The inclusive production of the ψ(2S) charmonium state was studied as a function of centrality in p-Pb collisions at the nucleon-nucleon center of mass energy √sNN = 5.02 TeV at the CERN LHC. The measurement was performed with the ALICE detector in the center of mass rapidity ranges −4.46 < ycms< −2.96 and 2.03 < ycms< 3.53, down to zero transverse momentum, by reconstructing the ψ(2S) decay to a
We have studied the effects of cytokines, separately or in combination, on the production of proteoglycans in confluent cultures of fibroblasts. The cytokines used were the transforming growth factor-beta (TGF-beta), the platelet derived growth factor-AA (PDGF-AA), the platelet derived growth factor-BB (PDGF-BB) and the epidermal growth factor (EGF). Hyaluronan production increased in cells treate
The measurement of prompt D-meson production as a function of multiplicity in p-Pb collisions at sNN=5.02 TeV with the ALICE detector at the LHC is reported. D0, D+ and D∗+ mesons are reconstructed via their hadronic decay channels in the centre-of-mass rapidity range −0.96 < ycms< 0.04 and transverse momentum interval 1
We propose a general approach to describe spreading widths of monopole, dipole, and quadrupole giant resonances in heavy and superheavy spherical nuclei. Our approach is based on the ideas of the random matrix distribution of the coupling between one-phonon and two-phonon states generated in the random-phase approximation. We use the Skyrme interaction SLy4 as our model Hamiltonian to create a sin
In sensor network applications with low traffic intensity, idle channel listening is one of the main sources of energy waste. The use of a dedicated low-power wake-up receiver (WRx), which utilizes duty-cycled channel listening, can significantly reduce the idle listening energy cost. Extreme low-power design typically leads to performance losses, indirectly increasing energy costs. Striking the r
Genetic polymorphisms are powerful model systems to study the maintenance of diversity in nature. In some systems, polymorphisms are limited to female coloration; these are thought to have arisen as a consequence of reducing male mating harassment, commonly resulting in negative frequency-dependent selection on female color morphs. One example is the damselfly Ischnura elegans, which shows three f
A selection of searches by the ATLAS experiment at the LHC for the electroweak production of SUSY particles are used to study their impact on the constraints on dark matter candidates. The searches use 20 fb−1 of proton-proton collision data at s=8 TeV. A likelihood-driven scan of a five-dimensional effective model focusing on the gaugino-higgsino and Higgs sector of the phenomenological minimal s
3D Direct Numerical Simulation (DNS) study of propagation of a single-reaction wave in forced, statistically stationary, homogeneous, isotropic, and constant-density turbulence was performed in order to evaluate both developing Ut T and fully developed Us T bulk turbulent consumption velocities by independently varying a ratio of 0.5 ≤ u'=SL ≤ 90 of the r.m.s. turbulent velocity to the laminar wav
Background: There is no biomarker with high sensitivity and specificity for the development of acute kidney injury (AKI) in a mixed intensive care unit (ICU) population. Heparin-binding protein (HBP) is released from granulocytes and causes increased vascular permeability which plays a role in the development of AKI in sepsis and ischemia. The aim of this study was to investigate whether plasma le
The alcoholysis of triolein was used to explore the specific features of a recombinant Rhizopus oryzae lipase (rROL) for biodiesel synthesis. For this purpose, different acylglycerols were compared as substrates in lipase-catalysed transesterification. rROL was shown to exhibit a higher specificity towards 1-monoolein than triolein compared to other R. oryzae lipases, being more than 4-fold more s
Background: The Autism Diagnostic Interview-Revised (ADI-R) is considered a first choice assessment tool in autism spectrum disorder. Nevertheless, despite its wide use in psychiatric practice and recommendations by various clinical guidelines, its interrater reliability has predominantly been confirmed in research settings by specially trained, research reliability interviewers. The reliability o
The aim of this paper is to explore the establishment of diplomatic representation as a measure of de facto recognition by other state units, and to explain its causes in the “long 19th century” (1817-1914). The premise of the paper is that, at least before the advent of broad-ranging legitimizing international organizations such as the League of Nations or the UN in the 20th century, sending a di
Background: Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of posterior fossa tumour surgery is the cerebellar mutism syndrome (CMS) which has been reported in up to 39% of the patients but the exact incidence is uncertain since milder cases may
Previous work in the areas of organizational trust repair and crisis communication has provided conflicting answers to the question of whether denial can be more effective than apology in repairing stakeholder trust in a company following an integrity-based violation. This article reportsthe results of an experiment designed to (i) test the effects of these two strategies on individuals’ trust in
Introduction: Severe obstetric complications increase with the number of previous cesarean deliveries. In the Nordic countries most women have two children. We present the risk of severe obstetric complications at the delivery following a first elective or emergency cesarean and the risk by intended mode of second delivery. Material and methods: A two-year population-based data collection of sever
