Filetype
Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathoge
We analyzed treatment and outcome in 104 Scandinavian patients with synovial sarcoma in the extremities or trunk wall, diagnosed between 1986 and 1994. Only surgically treated patients without metastases at diagnosis were included. Median follow-up of survivors was 6 (3-11) years. 34 patients developed metastases. The overall 5- and 7-year survival rates were 0.76 (95% Cl 0.66-0.83) and 0.69 (0.58
Portacaval-shunted and sham-operated male rats, fed ad libitum and of similar weight, were studied 2-3 weeks after surgery. At this time serum cholesterol levels did not differ significantly between the two groups, whereas serum triacylglycerols and phospholipids were lower in the shunted group. These animals also showed an increased serum bile acid level and an increased serum estradiol to testos
Transcript variants of the estrogen receptor (ER) were investigated in 109 primary breast tumors using reverse transcription-polymerase chain reaction (RT-PCR) and primers allowing analysis of each internal exon. A high incidence of different ER variants was observed, each individual tumor often manifesting multiple variants coexisting with corresponding wildtype (wt) ER. These variants, by sequen
In this paper, I give a short description of a language change that can be viewedas an instance of grammaticalization, namely the transition of the two adjectivesmycken/t and liten/t into quantifiers. Data from the corpus of Swedish drama dialogue reveal that liten/t became a quantifier as early as the 1700s, whereas mycken/t seems to have gone through the same change roughly 150 years later. Inhe
The determination of the CP nature of the Higgs coupling to top quarks is addressed in this paper, using tt-h events produced in s=13 TeV proton-proton collisions at the LHC. Dileptonic final states are employed, with two oppositely charged leptons and four jets, corresponding to the decays t→bW+→b+ν, t-→b-W-→b--ν-, and h→bb-. Pure scalar (h=H), pure pseudoscalar (h=A), and CP-violating Higgs boso
ObjectivesAccording to the Istanbul declaration, health services should create better routines for identifying potential donors. A previous study involving 702 intensive and critical care (ICU) nurses revealed that only 48% trusted clinical diagnosis of brain death without a confirmatory cerebral angiography. The aim was to study ICU nurses’ perceptions of their experiences of professional respons
The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba2+ and K+ in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by
Proinsulin-connecting peptide (C-peptide) exerts physiological effects partially via stimulation of Na+, K+-ATPase. We determined the molecular mechanism by which C-peptide stimulates Na+,K +-ATPase in primary human renal tubular cells (HRTCs). Incubation of the cells with 5 nM human C-peptide at 37°C for 10 min stimulated 86Rb+ uptake by 40% (p<0.01). The carboxy-terminal pentapeptide was found t
The abstract with its heading should not be more than 75 mm long. This is equivalent to 18 lines of text. Leave 1 line space at the bottom of the abstract before continuing with the next heading. The autonomic nervous system modulates atrial electrophysiology in atrial fibrillation (AF). The purpose of this study was (1) to non-invasively characterize the effects of exercise on atrial fibrillatory
We have constructed a compact soft X-ray emission spectrometer at the BL-09A beamline of the NewSUBARU synchrotron radiation facility at the University of Hyogo, Japan. Using this spectrometer, we observed a large take-off angle dependence of C-K emissions in highly oriented pyrolytic graphite (HOPG). At an excitation photon energy of 310 eV, far from the absorption edge of HOPG, we detected large
Although hoarding has been studied intensively for many decades, few studies have attempted to measure its actual fitness consequences. To fill this gap, we used ptilochronology, the growth of replacement feathers as a measure of nutritional status, and thus a reflection of starvation risk, of individual European nuthatches (Sitta europaea) during winter. We found that nuthatches are long-term hoa
γ-Aminobutyric acid (GABA) increases the rate of 36Cl- efflux from preloaded rat hippocampal slices in a dose-dependent manner (EC50: 400 μM). This action has the pharmacological specificity expected of activation of GABA receptor in that it is mimicked by the agonists muscimol and 3-aminopropanesulfonic acid, and blocked by the antagonists bicuculline and picrotoxinin. GABA uptake inhibitors, nip
One of the challenges in wooden constructions is to be able to achieve a good acoustic insulation especially in the low frequency range. The prediction of acoustic performance of wooden buildings before erection becomes important and reliable predictive tools are in great need. To that end, the first question that arises is how to accurately model the excitation source which generates the structur
