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Background Studies on the survival of patients with home mechanical ventilation (HMV) are sparse. We aimed to analyse the impact of controlled hypercapnia on survival over 27 years among patients with HMV in Sweden. Study design and methods Population-based cohort study of adult patients starting HMV in the Swedish Registry for Respiratory Failure (Swedevox) during 1996–2022 cross-linked with the
Purpose: A lack of standardization exists for functional tasks in return-to-activity (RTA) guidelines for adolescents with anterior cruciate ligament injury (ACLi). Identifying the variables that discern ACLi status among adolescents is a first step in the creation of such guidelines following surgical reconstruction. This study investigated the use of classification models to discern ACLi status
Pravastatin has neuroprotective effects against aging but its role in brain injury remains unclear. This study evaluated the effects of pravastatin on the ultrastructural changes and hemorheological parameters in rats after traumatic brain injury (TBI) of right parietal cortical contusion by a controlled weight-dropping method. There were three groups: (I) Sham operated group; (II) TBI + vehicle (
INTRODUCTION: Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers. METHODS: We thoroughly investigated the ability of various machine learning models to predict clinically useful tau-PET composites (load and laterality index) from low-cost an
BackgroundThe lack of effective screening methods for the detection of ovarian cancer leads to late diagnosis and poor outcomes. High-grade serous ovarian carcinoma (HGSC) is strongly dominated by copy number alterations (CNAs), resulting from underlying mutational processes. Several studies have reported the detection of ovarian carcinoma-derived somatic mutations in cervical samples, uterine lav
Objective: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are heterogeneous disorders. The aim of this study was to identify and characterize subgroups of patients based on sex, ANCA, age at diagnosis, and organ involvement. Methods: In total, 1,167 patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were retrospectively recruited to the s
OBJECTIVES: Short time to positivity (TTP) has been proposed as a prognostic indicator in bloodstream infection (BSI) but results have been conflicting. The aim of this study was to explore the association between TTP and disease severity, using non-linear models.METHODS: This population-based retrospective study included all blood cultures in southern Sweden from 2021 to 2023. Using healthcare da
Background: In the Malmö Breast Tomosynthesis Screening Trial (MBTST), digital breast tomosynthesis (DBT) increased the detection rate of breast cancer compared to currently used digital mammography (DM). This study evaluated the cost effectiveness of DBT versus DM in Sweden using data from MBTST. Materials and method: A health economic model was used to compare a breast cancer screening programme
Background: Aortic valve calcification (AVC) is an underlying pathophysiological mechanism in aortic stenosis, which shares many risk factors with diabetes. However, the association between dysglycemia and early stages of AVC remains unclear. The aim was to examine the associations between stages of dysglycemia and signs of AVC among middle-aged individuals from the general population. Methods: Th
Increasing economic, social and environmental limits to the development of conventional water supply sources have shifted water resource frontiers to alternative sources, most notably desalination and wastewater reuse. In the past few years, critical scholarship has been prolific in its exploration of how desalination may redraw the hydrosocial cycle in different geographies; wastewater reuse, how
Decades of criminological research have highlighted the principle that “place matters” when analysing crime dynamics. While acknowledging this, our study emphasises that place matters at specific times of the day and days of the week. This paper explores spatiotemporal patterns of assaults in public spaces in Stockholm, Sweden, using a time–space modeling approach. By segmenting annual crime regis
During the Last Glacial Period (LGP), Greenland experienced approximately 30 abrupt warming phases, known as Dansgaard-Oeschger (D-O) events, followed by cooling back to baseline glacial conditions. Studies of mean climate change across warming transitions reveal indistinguishable phase offsets between shifts in temperature, dust, sea salt, accumulation, and moisture source, thus preventing a comp
Amyloid-β (Aβ) positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) biomarkers are now established tools in the diagnostic workup of patients with Alzheimer's disease (AD), and their use is anticipated to increase with the introduction of new disease-modifying therapies. Although these biomarkers are comparable alternatives in research settings to determine Aβ status, biomarker
Everyday driving relies on cognitive functions such as visual search, change detection and predictive attention for maintaining a high-level mental model of the world. Such functions are especially constrained by limited cognitive resources under complex conditions. Understanding the manner in which environmental complexity influences cognitive driving performance is key to improving road safety a
Background: Atrial fibrillation (AF) is the most common arrhythmia worldwide and the majority of AF patients are treated in primary care. In order to minimize hospitalizations and visits to emergency departments, nurse-led care was introduced in secondary care and primary health care (PHC). However, even though nurse-led care was initiated in PHC almost a decade ago, and ESC guidelines recommended
BACKGROUND: In this study, we combine proteomics with functional parameters and imaging to examine potential biomarkers that may identify patients at risk of developing persistent lung sequelae following coronavirus disease 2019 (COVID-19).METHODS: We performed multiplex profiling of serum and collected clinical data from intensive care unit (ICU)-treated patients with COVID-19 (n=43) at 4 and 10
AIM: To investigate the diagnostic accuracy of procalcitonin (PCT), C-reactive protein (CRP) and absolute neutrophil count (ANC) to rule out invasive bacterial infections (IBI) in well-appearing febrile infants aged ≤ 60 days.METHODS: Multicentre study of infants ≤ 60 days with fever without source. We calculated the sensitivity, specificity, positive predictive value (PPV) and negative predictive
The evolution of media has gained much headway this past decade and has outpaced many countries’ ability to keep up. It has even left linguistic gaps in the Arabic language, and has sparked one Jordanian, Muhammed Jaradat, to create new Arabic terminology to fill this social media language gap. As internet proliferation increases in Arab countries and access to higher connection speeds becomes ava
