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The salinization of freshwaters is a global threat to aquatic biodiversity. We quantified variation in chloride (Cl−) tolerance of 19 freshwater zooplankton species in four countries to answer three questions: (1) How much variation in Cl− tolerance is present among populations? (2) What factors predict intraspecific variation in Cl− tolerance? (3) Must we account for intraspecific variation to ac
Cross-laminated timber (CLT) floors with supplementary layers or floating floors comprise a common solution in new multistory timber structures. However, bare CLT components provide poor sound insulation, especially in low frequencies during structure-borne sound propagation. Thus, floor configurations in wooden buildings deploy more layers for improved acoustic behavior. Twelve contemporary CLT f
This photo essay addresses the work and rituals surrounding the making and printing of genealogies in post-socialist China. The essay documents how lineages and printmakers negotiate a new socio-economic environment under the process of heritagization, the materiality and labor of printmaking, and the spaces in which work and rituals takes place. It adds to our understanding of the continuing impo
Due to the large number of electrons, solid state physics boils down to many-body approximations in which only selected types of collective excitations are taken into account, guided by the emergent properties of the material under study. In this thesis, the collective excitations of primary interest are electronic charge and spin fluctuations(plasmons and magnons) and nuclear charge fluctuations
PURPOSE: Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R) expression in tumours might be used for selection of patients who would benefit from IGF-1R-targeted therapy. We have previously shown the feasibility of IGF-1R imaging using the Affibody molecule (111)In-DOTA-His(6)-Z(IGF1R:4551). The use of (99m)Tc instead of (111)In should improve sensitivity and resolution of
This work is a continuation of the research recently presented in [1] and [2] on the determination of residual thermal stresses in graphite/polyimide composites with and without externally applied bending loads. In the previous work [1, 2] a combined experimental and numerical methodology for the determination of the residual stresses in unidirectional graphite/PMR-15 composites based on X-ray dif
The purpose of this research is to determine residual thermal stresses in a unidirectional graphite-fiberT/PMR-15 polyimide composite by using crystalline inclusions. X-ray diffraction (XRD) measurements have been made to determine residual stresses in embedded aluminum and silver inclusions placed between the first and second plies of six-ply unidirectional graphite/PMR-15 composite specimens. In
Background: Contact allergy can manifest in a variety of ways clinically. Systemic contact allergy may occasionally present with pain in muscles and joints. Fibromyalgia is a chronic rheumatic disease characterized by pain and with virtually unknown aetiology. Objectives: The aim of this study was to investigate the contact allergy rates to the sensitizers in a baseline series and compare with cor
BACKGROUND Anaesthesiology represents a rapidly evolving medical specialty in global healthcare, currently covering advanced peri-operative, pre-hospital and in-hospital critical emergency management (CREM), intensive care medicine (ICM) and pain management. The aim of the European Society of Anaesthesiology and Intensive Care (ESAIC) is to develop and promote a coordinated interdisciplinary and m
Optimizing the benefits versus harms of prostate-specific antigen screening can be achieved through stratifying screening and biopsy. This clinical consultation guide provides the scientific background and evidence-based recommendations.
Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods: We analysed targeted metabolomics data
Semenogelin I and semenogelin II constitute the major gel-forming proteins in human semen. The gel proteins were rapidly solubilized and separated from spermatozoa in ejaculates collected at pH 9.7 in buffer containing 4 mol/l urea and dithiothreitol. This protected the semenogelins from proteolytic degradation by prostate-specific antigen, and allowed their isolation by affinity chromatograph:g o
Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid
Pop is increasingly assimilating the compositional practices of hip- hop and EDM (electronic dance music). This shift is driven by a new generation of Digital Audio Workstations (DAWs). These are less based on a recording studio logic and more a combination of controlling loops and the networked logic of ubiquitous computing (ubicomp) culture. Via new media theory, this article discusses how the p
Melanin pigments play a critical role in physiological processes and shaping animal behaviour. Fossil melanin is a unique resource for understanding the functional evolution of melanin but the impact of fossilisation on molecular signatures for eumelanin and, especially, phaeomelanin is not fully understood. Here we present a model for the chemical taphonomy of fossil eumelanin and phaeomelanin ba
Background and Objective: The number of reports on suspected drug-induced memory impairment submitted to the US Food and Drug Administration increased 30-fold from 2000 to 2022. Drugs are the most common cause of reversible dementia. However, there is very little research on drug-induced cognitive impairment. The aim of this study was to investigate if and how an assessment of cognitive safety was
Introduction: Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are two groups of inherited retinal diseases (IRDs) where the rod photoreceptors degenerate followed by the cone photoreceptors of the retina. A genetic diagnosis for IRDs is challenging since >280 genes are associated with these conditions. While whole exome sequencing (WES) is commonly used by diagnostic facilities, the
