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UNLABELLED: We sought to investigate the inter- and intra-country variation in paediatric heart transplantation (HTx) and mechanical circulatory support (MCS) availability and practice in Europe. Data was obtained through a survey circulated to paediatric transplant cardiologists identified through the Association of European Paediatric and Congenital Cardiology between November 2022 and March 202
In the New Testament gospel accounts of the empty tomb, there is a strong emphasis on vision and sight. This emphasis is at times understood as a reference to the role of eyewitnesses and their testimonies in the formation of the gospel tradition. This study, however, reads the visual elements of the texts as part of their poetics, as part of their narrative and rhetorical setting.By looking at ei
At the turn of the twentieth century, infant- and child mortality declined rapidly in many industrializing societies. In Sweden, this decline coincided with industrialization and urbanization, as well as a period of growing social disparities in childhood mortality. The inequality in child survival was connected to a range of factors, including access to water- and sanitation, housing conditions,
Bone conduction hearing implant systems (BCHIs) are established treatments for patients with conductive or mixed hearing loss or single-sided deafness when conventional hearing aids are unsuitable. This study evaluated the cost-effectiveness of the active transcutaneous system Sentio versus a similar system, i.e., Osia in an Australian setting. Scenario analyses also compared Sentio to other syste
The Gaussian β-ensemble is a real n-point configuration {xj}n1 picked randomly with respect to the Boltzmann factor e− β 2 Hn, where Hn = ∑i≠j log |xi−1xj| + n ∑ni=112 xi2. It is well known that the point process {xj }n1 tends to follow the semicircle law σ (x) = 21π√(4 − x2 )+ in certain average senses. A Fekete configuration (minimizer of Hn) is spread out in a much more uniform way in the inter
Context. The nuclear stellar disc (NSD) of the Milky Way is a dense, rotating stellar system in the central ~200 pc. The NSD is thought to be primarily fuelled by bar-driven gas inflows from the inner Galactic disc. Aims. As part of the LEGARE project, we aim to construct the first chemical-evolution models for the NSD using a Bayesian approach tailored to reproducing the observed metallicity-dist
The focus of this study was to evaluate the feasibility of incorporating Perlin noise, a method that has previously been used to model the tissue distribution of software breast phantoms, when creating a ‘compressible’ software breast phantom used in finite element analysis. Several compressible phantoms were created to represent different stages of aging in a virtual patient when younger, fibrogl
Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial wall. CD4+ T cells, some of which recognize peptide components of LDL as antigen, are recruited to the forming lesion, resulting in T-cell activation. Although these T cells are thought to be proatherogenic, LDL immunizat
Local knowledge plays a central yet uneven role in climate change policymaking. Drawing on the concept of climate eco-governmentality, this paper examines how interactions among actors, knowledge, and scales shape the governance of mangrove ecosystems in the Colombian Caribbean. Building on critical climate change and political ecology scholarship, I analyse how knowledge produced by local communi
Human peripheral blood mononuclear cells (PBMCs) can be easily sampled from healthy individuals and patients. Density gradient isolation from human blood or leukocyte concentrates yields a mononuclear cell population of mainly lymphocytes, monocytes, and natural killer (NK) cells. PBMCs are vital circulating cells of the immune system and rely on oxidative phosphorylation (OXPHOS) for their energy
Denna avhandling undersöker den samtida nedmonteringen av civilsamhället i Indien genom begreppet civic governmentality. Avhandlingen hävdar att krisen för det civilas handlingsutrymme inte enbart är en berättelse om förtryck, utan om hur förutsättningarna för det civila på ett genomgripande sätt förändrats och nu präglas av auktoritär nyliberal styrning. I kontrast till dominerande narrativ som fThis thesis interrogates the contemporary unmaking of civil society in India through the analytic of civic governmentality, arguing that the crisis of civic space is not merely a story of repression but of the deeper remaking of civic subjectivity under conditions of authoritarian neoliberal rule. Against narratives that cast international non-governmental organisations (INGOs) as either heroic re
Introduction: Cervical cancer represents a significant public health challenge worldwide. To improve screening accessibility and participation, we implemented vaginal human papilloma virus (HPV) self-sampling as part of an organized cervical cancer prevention strategy. This study aimed to evaluate the implementation and outcomes of the self-sampling program in a real-world setting. Material and Me
Background: Adjuvant therapy of breast cancer patients reduces the risk of recurrence and mortality, although, a substantial proportion of patients acquire resistance and relapse in the disease. Predictors of therapeutic response are therefore important to avoid both therapy resistance and the side effects of inefficient regimes. The p53 protein is a key determinant to induce either growth arrest
Structured Abstract Background Sexual health and functioning are significant, yet often overlooked, components of psychosocial well-being of adults with congenital heart disease (ACHD). Prior research reports inconsistent findings, limited data on older adults with CHD, and few studies have compared patients with controls from the general population. This study investigated sexual functioning in m
Context: Nitrate contamination of groundwater, driven by human activities such as agriculture and urbanization, poses a significant global challenge. Objective: We aimed to identify the major drivers of nitrogen load (nitrogen pollution generation potential) and quantify spatial disparities in nitrogen load productivity across administrative divisions in the Kumamoto area from 1960 to 2020 under e
Ambivalence is widely regarded as a source of ontological insecurity and anxiety due to its close association with uncertainty, undecidability, and indeterminacy. While ontological security studies (OSS) has usefully engaged with the concept of ambivalence as an epistemic phenomenon and its manifestations in international politics such as ‘strangers’, almost no attention has been paid to ambivalen
Background: Photon-counting computed tomography (PCCT) is an emerging technique under evaluation for temporal bone imaging. Its capacity for radiation dose reduction while maintaining diagnostic image quality (IQ) requires further study. Purpose: To evaluate how PCCT compares to energy-integrating CT (EICT) in temporal bone imaging in terms of IQ and visualization of anatomical landmarks, at a cli
Human pluripotent stem cell-derived in vitro models, combined with advances in high-content live-cell calcium imaging, provide a powerful platform for disease modeling and drug screening. However, most calcium imaging analysis tools have been developed for in vivo applications with suboptimal features for processing data from cultured neurons. Here, we present LUMIN (Live-cell User Module for Imag
How do actors overlook uncomfortable information? We add to the understanding of how potential problems can be ignored over long periods, in spite of recurrent warnings. Ignoring then becomes a dynamic process of responding to evolving ignoring ‘threats’ or triggers by combining knowledge-seeking and knowledge avoidance in ways that must be continuously legitimated, both in one’s own eyes and in t
