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The Amazonian Craton is host to one of Earth’s largest Proterozoic silicic large igneous provinces (SLIPs), the Orocaima SLIP (ca. 1.98 Ga). Nevertheless, the mechanism(s) responsible for this large-flux felsic magmatic event and its relationships with regional tectonics and/or mantle processes remain debated. New geochronologic and geochemical results from multiple mafic dike swarms in the Amazon
BackgroundAmyloid-β peptides (Aβ) applied to Alzheimer's disease (AD) brain bind to amyloid plaques (APs) and this binding is saturable. Meanwhile, anti-immunoglobulin G (IgG) antibodies label APs. Considering the saturable binding of Aβ to APs and the localization of IgGs in APs, specific binding proteins (BPs) for the applied Aβ could be anti-Aβ IgG antibodies (anti-AβAbs) in APs.ObjectiveOur ob
This study explores how higher music education institutions position themselves in relation to wider social and political forces and the expanding professional responsibilities of musicians in increasingly complex Nordic societies, which in this study includes Finland, Sweden, Norway and Denmark. By asking how the political—including various local and global social-ecological values, relations and
Autocracies have increasingly begun to clothe themselves in the guise of hybrid, semi-official institutions that exhibit a degree of autonomy from the state, such as Government-Organized NGOs (GONGOs), “zombie” election observers, regime-run think tanks, astroturfing, or semi-official state-mobilized movements (SMMs). Existing literature has analyzed hybrid institutions as products of their functi
Movement disorders are common in inherited metabolic diseases (IMDs) and significantly impact quality of life. Unfortunately, they are often underrecognised by metabolic physicians. This study investigated whether a new screening tool improves recognition of movement disorders in IMD patients by non-neurologists. Internists and paediatricians specialized in IMDs assessed videos of 44 IMD patients
AIM: Right ventricular (RV) function determines symptom burden and clinical outcomes in pulmonary hypertension (PH). Global wasted work (GWW) quantifies mechanical inefficiencies in RV performance associated with elevated afterload, but is inadequately characterized in precapillary PH. We assessed the association of GWW with echocardiographic indices of RV remodeling, RV-PA coupling and invasive h
Cigarette smoke (CS), a major driver of lung cancer (LC), promotes epithelial-mesenchymal transition (EMT) and stemness resulting in metastasis, therapy resistance, and recurrence, but the precise mechanism is elusive. Building on our earlier identification of Runt related transcription factor-2 (RUNX2) and Galectin-3 (Gal-3) as mediators of CS-induced EMT, in this study, we aimed to identify a po
Human-induced habitat loss, fragmentation and degradation are among the leading causes of species decline worldwide. This is particularly true in tropical forests, where unique, often highly specialized fauna is under threat. By altering resource availability, anthropogenic habitat change can impose resource constraints on animals and may influence their allocation of resources to competing life h
Accurate global estimates of accumulation-mode particle number concentrations (N100) are essential for understanding aerosol–cloud interactions and their climate effects and for improving Earth system models. However, traditional methods relying on sparse in situ measurements lack comprehensive coverage, and indirect satellite retrievals have limited sensitivity in the relevant size range. To over
In 2003, the Swedish Municipal Workers’ Union (Kommunal) called a nationwide strike, demanding a pay rise for all members in the public sector. Drawing on oral history interviews with workplace representatives and local union officials, the article examines how the struggle enabled changes in subjectivity, generating utopian visions for increased visibility and agency for municipal workers. This p
In Nordic countries, demand response (DR) programs are critical for enhancing energy flexibility and reducing peak electricity consumption in buildings and industry. Accurate short-term demand forecasting is essential to support these programs, especially in the context of cities with varying levels of data availability. This paper compares three different forecasting approaches for hourly electri
The observation of the electroweak production of single-top-quarks is made using 255 pb−1 of proton-proton collision data recorded at s=5.02 TeV with the ATLAS detector at the Large Hadron Collider. An event selection is used to identify single-top-quark candidates arising from t-channel production with the top quark decaying semi-leptonically. Events passing the selection are then used to measure
Results on the transverse spherocity dependence of light-flavor particle production (π, K, p, ϕ, K*0, KS0, Λ, Ξ) at midrapidity in high-multiplicity pp collisions at s = 13 TeV were obtained with the ALICE apparatus. The transverse spherocity estimator SOp categorizes events by their azimuthal topology. Utilizing narrow selections on SOp, it is possible to contrast particle production in collision
Within the stroma of pancreatic ductal adenocarcinoma (PDAC), mesenchymal cells differentiate into cancer-associated fibroblast (CAF) subtypes that differentially mediate disease progression. Defining the regulatory mechanism and diversity of CAF subtypes could identify potential therapeutic strategies to harness the tumor-suppressive activities of CAFs. To address this, we utilized single-cell RN
BACKGROUND AND OBJECTIVES: Addressing the association between early-changing Alzheimer disease (AD) biomarkers and cognition is essential for characterizing preclinical AD. However, few studies have explored this relationship longitudinally, especially across multiple biomarker modalities. The aim of this study was to evaluate longitudinal associations of multimodal core 1 AD biomarkers with cogni
The 13th century AD in southern Africa is a period associated with the emergence of class-based society and the establishment of Mapungubwe as the capital of a regional state. This study reports on ceramics excavated from four households at Bosbokpoort, a small Mapungubwe settlement situated approximately 95 km from Mapungubwe. By combining traditional stylistic analysis with chemical (pXRF) and m
Underpinning the project of massification of higher education (HE) is the stated aim to make HE accessible and equitable to all those who could benefit from it. Nevertheless, key metrics of success–access and participation, retention, degree outcomes–reveal inequalities related to race, gender and social class. Policies at both institutional and national levels, across international settings, aim
Aims This study aimed to test whether seismocardiography (SCG) can detect changes in loading conditions and detect significant differences in SCG signals between healthy individuals and those with cardiovascular disease (CVD). Methods Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 11 healthy subjects and 15 subjects with CVD. SCG and results was compared with transthoracic ech
