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INTRODUCTION: As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.RESEARCH QUESTION: To reach a consensus among exp
The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. H
Group A streptococci (GAS) cause three different types of infection (sensu lato) with distinct levels of virulence: asymptomatic colonization, superficial symptomatic infection, and invasive infection. To address why this pattern with several infection types has evolved, we combine mechanistic understanding from infection medicine with recent theory from evolutionary ecology. We propose that asymp
While the international community debates the desirability and possible content of a new global instrument for the conservation and sustainable use of marine biodiversity in areas beyond national jurisdiction, alternative approaches to improving the application and implementation of existing agreements for the protection of biodiversity appear to have fallen off the agenda. Recent practice under e
Rye bran was added to frankfurter-type sausages and meatballs with the aim of producing low-fat products with increased dietary fibre content. The addition of untreated rye bran to sausages was detrimental, causing a substantial increase in frying loss (20% compared to 13.2%). The addition of rye bran treated with hydrolytic enzymes reduced the frying loss to 15.2-16.4%. The firmness was also impr
Protein S has an established role in the protein C anticoagulant pathway, where it enhances the factor Va (FVa) and factor VIIIa (FVIIIa) inactivating property of activated protein C (APC). Despite its physiological role and clinical importance, the molecular basis of its action is not fully understood. To clarify the mechanism of the protein S interaction with APC, we have constructed and express
To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.
The earliest stages of natural killer (NK) cell development are not well characterized. In this study, we investigated in different fetal hematopoietic tissues how NK cell progenitors and their mature NK cell progeny emerge and expand during fetal development. Here we demonstrate, for the first time, that the counterpart of adult bone marrow Lin(-)CD122(+)NK1.1(-)DX5(-) NK cell progenitor (NKP) em
Post-cardiac arrest syndrome (PCAS) is characterized by systemic inflammation, however data on the prognostic value of inflammatory markers is sparse. We sought to investigate the importance of systemic inflammation, assessed by interleukin-6 (IL-6) in comatose survivors of out-of-hospital cardiac arrest.
The diffusion behavior of the conjugated polyelectrolyte poly{[9,9-bis(6'-N,N,N-trimethylammonium)hexyl]fluorene-phenylene) bromide (HTMA-PFP) with different molecular weights has been studied in dimethyl sulfoxide (DMSO) + water solutions. Samples of HTMA-PFP with various molecular weights were obtained by synthesis of poly[9,9-bis(6'-bromohexyl)fluorene-phenylene] via a Suzuki coupling reaction,
Cellulose-inferred lakewater oxygen-isotope records have been obtained from two hydrologically open basins (Lake Spaime and Lake Svartkalstjarn), located on a west east transect across central Sweden, to investigate changes in atmospheric circulation patterns during the Holocene. The Lake Spaime delta O-18 record is sensitive to changes in the seasonal distribution of precipitation in the Scandes
The effect of hydrogen enrichment to natural gas flames was experimentally investigated at atmospheric pressure conditions using flame chemiluminescence imaging, planar laser-induced fluorescence of hydroxyl radicals (OH PLIF), and dynamic pressure monitoring. The experiments were performed using a third generation dry low emission (DLE) burner used in both SGT-700 and SGT-800 industrial gas turbi
Unilateral intrastriatal and intra-medial forebrain bundle injections of 6-OHDA impair the performance in a lateralised choice reaction time task. However, the extent and pattern of deficits after nigral 6-OHDA injections is less well studied, as well as the impact of training regime or the modification of various task parameters. The nigral 6-OHDA lesion resulted in impaired response accuracy and
Objective To assess the accuracy of the Wells rule for excluding deep vein thrombosis and whether this accuracy applies to different subgroups of patients. Design Meta-analysis of individual patient data. Data sources Authors of 13 studies (n=10 002) provided their datasets, and these individual patient data were merged into one dataset. Eligibility criteria Studies were eligible if they enrolled
Abstract in UndeterminedThe question of how new regional growth paths emerge has been raised by many leading economic geographers. From an evolutionary perspective, there are strong reasons to believe that regions are most likely to branch into industries that are technologically related to the preexisting industries in the regions. Using a new indicator of technological relatedness between manufa
Purpose Psychological flexibility is the theoretical model that underpins Acceptance Commitment Therapy (ACT). There is a growing body of evidence indicating that ACT is an effective treatment for chronic pain but one component of the model, committed action, has not been sufficiently researched. The purpose of this study is to validate Swedish-language versions of the full length Committed Action
Rate control of atrial fibrillation (AF) is a main treatment modality. However, data are scarce on the relative efficacy of calcium channel blockers and 13 blockers or between drugs within each class. The purpose of the present study was to compare the effect of 4 rate-reducing, once-daily drug regimens on the ventricular heart rate and arrhythmia-related symptoms in patients with permanent AF. We
