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Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance tes
Objective: Ovarian clear cell carcinomas (OCCCs) constitute a rare ovarian cancer subtype with distinct clinical features, but may nonetheless be difficult to distinguish morphologically from other subtypes. There is limited knowledge of genetic events driving OCCC tumorigenesis beyond ARID1A, which is reportedly mutated in 30-50% of OCCCs. We aimed to further characterize OCCCs by combined global
The 39-2Ma Haughton impact structure on Devon Island comprises a thick target succession of sedimentary rocks, mainly carbonates. The carbonates contain pre-impact organic matter, including fossil biological markers. Haughton is located in an area where no major thermal event has affected the sedimentary succession after heating caused by impact. This makes Haughton uniquely suitable for studies c
The production of Z bosons with one or two isolated high-energy photons is studied using pp collisions at s=8 TeV. The analyses use a data sample with an integrated luminosity of 20.3 fb-1 collected by the ATLAS detector during the 2012 LHC data taking. The Zγ and Zγγ production cross sections are measured with leptonic (e+e-, μ+μ-, νν) decays of the Z boson, in extended fiducial regions defined i
Amine transaminase (ATA) catalyse enantioselectively the direct amination of ketones, but insufficient stability during catalysis limits their industrial applicability. Recently, we revealed that ATAs suffer from substrate-induced inactivation mechanism involving dissociation of the enzyme-cofactor intermediate. Here, we report on engineering the cofactor-ring-binding element, which also shapes th
The invariant differential cross sections for inclusive π0 and η mesons at midrapidity were measured in pp collisions at s=2.76 TeV for transverse momenta 0.4 < pT< 40 GeV/c and 0.6 < pT< 20 GeV/c, respectively, using the ALICE detector. This large range in pT was achieved by combining various analysis techniques and different triggers involving the electromagnetic calorimeter (EMCal). In particul
Lactones, cyclic esters of hydroxycarboxylic acids, are interesting biofuel candidates as they can be made from cellulosic biomass and have favorable physical and chemical properties for distribution and use. The reactions of γ-valerolactone (GVL), γ-crotonolactone (2(5H)-F), and α-methyl-γ-crotonolactone (3M-2(5H)-F) with Cl, OD, and O3 were investigated in a static chamber at 700 Torr and 298 ±
The dijet production cross section for jets containing a b-hadron (b-jets) has been measured in proton–proton collisions with a centre-of-mass energy of s=7 TeV, using the ATLAS detector at the LHC. The data used correspond to an integrated luminosity of 4.2fb-1. The cross section is measured for events with two identified b-jets with a transverse momentum pT> 20 GeV and a minimum separation in th
Measurements of the W±→ℓ±ν and Z→ℓ+ℓ− production cross sections (where ℓ±=e±,μ±) in proton–proton collisions at s=13 TeV are presented using data recorded by the ATLAS experiment at the Large Hadron Collider, corresponding to a total integrated luminosity of 81 pb−1. The total inclusive W±-boson production cross sections times the single-lepton-flavour branching ratios are σW+ tot=11.83±0.02 (stat
Purpose: In response to the need for hearing aids in low-income countries, an approach to provide hearing aids through trained community workers was developed. This study compares the effectiveness of the community-based approach with that of a centre-based approach. Methods: One hundred and forty adolescents (56% girls; 12–18 years; mean: 15 years) from eleven sub-districts participated in a clus
In this study, numerical simulations are conducted to investigate the effects of pin fin location, pin fin diameter, and pin fin shape on the target and pin fin surfaces heat transfer as well as friction factor in an improved Lamilloy cooling structure. The pin fin normalized location is varied from 0.35 to 0.65 while the pin fin diameter is changing from 15 mm to 60 mm. Cone-shaped pin fins are i
Platform ecosystems are becoming the locus of innovation-driven economies as technology-based platform within the ecosystem acts as the foundation for innovative product and services developed by the networked business community around that platform. At its core, a technology platform shows architectural properties, which once emerged in an industry could play as the de facto template for defining
The large rate of multiple simultaneous proton–proton interactions, or pile-up, generated by the Large Hadron Collider in Run 1 required the development of many new techniques to mitigate the adverse effects of these conditions. This paper describes the methods employed in the ATLAS experiment to correct for the impact of pile-up on jet energy and jet shapes, and for the presence of spurious addit
The membrane-anchoring subunit of Bacillus subtilis succinate:menaquinone reductase is a protein of 202 residues containing two protoheme IX groups with bis-histidine axial ligation. Residues Kis13, His28, His70, His113, and His155 are the possible heme ligands. The transmembrane topology of this cytochrome was analyzed using fusions to alkaline phosphatase. The results support a proposed model wi
ATLAS has measured two-particle correlations as a function of the relative azimuthal angle, Δφ, and pseudorapidity, Δη, in s=13 and 2.76 TeV pp collisions at the LHC using charged particles measured in the pseudorapidity interval |η|
The momentum-weighted sum of the charges of tracks associated to a jet is sensitive to the charge of the initiating quark or gluon. This paper presents a measurement of the distribution of momentum-weighted sums, called jet charge, in dijet events using 20.3 fb-1 of data recorded with the ATLAS detector at s=8 TeV in pp collisions at the LHC. The jet charge distribution is unfolded to remove disto
More than 95% of testicular cancer are cured but they are at increased long-term risk of cardiovascular disease. The risk of cardiovascular disease and treatment intensity was reported, but it is unknown whether this effect of cancer therapy is direct or indirect, mediated through androgen deficiency. Our aim was, therefore, to evaluate whether testicular cancer patients have increased the prevale
Background: The Tau PET ligand 18F-AV1451 has been shown to reliably detect paired helical filaments of tau in Alzheimer's disease, but it is not yet known whether it binds to the tau aggregates present in patients with mutations in the gene (MAPT) coding for the tau protein. Further, no study has yet compared the cerebral retention of 18F -AV1451 with the tau aggregates revealed using neuropathol
Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a commensal microbiota. These factors are essential for interconnected processes including immunity programming and the development of a normal infant gastrointestinal microbiome. Newborn immune protection mostly relies on maternal immune factors provided through
OBJECTIVE:: Arterial stiffening increases with age and is associated with increased cardiovascular risk. Several risk factors have been shown to predict the development of arterial stiffening; however, a positive family history (FH+) of cardiometabolic disease (CMD) and hypertension has not been extensively studied. We hypothesize that FH+ of CMD plays a significant role in the development of arte
