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Fluorinated quinolones exert their bactericidal activity by inhibiting bacterial type II topoisomerases. At therapeutic concentrations, quinolones superinduce interleukin-2 (IL-2) and interferon-gamma production by mitogen-activated human peripheral blood T lymphocytes. At the molecular level, a stronger activation of the nuclear factor AP-1 ('activator protein-1') is observed in cells incubated w

Popular Abstract in Swedish (Summary in Swedish) Urininkontinens är ett stort folkhälsoproblem. Ungefär 10 % av kvinnor i 40-årsåldern är drabbade och andelen inkontinenta ökar med ökande ålder. Den vanligaste formen av urininkontinens är så kallad ansträngningsinkontinens med de typiska symptomen urinläckage vid hosta, tunga lyft och gymnastik. I uttalade fall kan dock läckage uppstå redan vid daThe etiology of female stress urinary incontinence (SUI) is unclear. By linking three nationwide medical registries we evaluated maternal and obstetric factors associated with later SUI surgery. Surgery for SUI was strongly associated with vaginal delivery, but not with pregnancy as such. Maternal conditions and interventions during delivery modified the association. Proper evaluation of treatment

Knowledge of a patient's perception of her medical needs and urgency may make it possible for emergency nurses to communicate the triage decision and make the patient understand the assessment and triage category. The aim of this study was to compare the patients' own assessments of their acuity to the triage nurse's assessment, as well as describe patient satisfaction and levels of anxiety.

Phosphorylation of the α-synuclein (α-syn) protein at Ser129 [P(S129)-α-] was found to be the most abundant form in intracellular inclusions in brains from Parkinson's disease (PD) patients. This finding suggests that P(S129)-α-syn plays a central role in the pathogenesis of PD. However, it is at present unclear whether P(S129)-α-syn is pathogenic driving the neurodegenerative process. Rodent stud

A new device for stopping or reducing potentially irritating or harmful emissions from surfaces indoors is described. The device is a surface emissions trap prototype and consists of an adsorbent sheet with a semipermeable barrier surrounded by two thin nonwoven layers. The trap may be applied directly at the source of the emissions e.g. at moisture-affected floors and walls, surfaces contaminated

The main focus of this contribution consists in the elaboration of a continuum modelling approach accounting for dislocation-based quantities. Related deformation dependent history-variables are attached to individual material points and, moreover, are extended by means of gradients thereof so that so-called weak non-localities are captured. These gradients of internal variables may be further spe

This paper deals with Kripke’s influential criticism of the view that mental states are physical in nature, i.e. that such states are identical with certain physical states or processes.

Introduction 1 ON THE FULFILLMENT OF MORAL OBLIGATION Michael J. Zimmerman Department of Philosophy, University of North Carolina at Greensboro m_zimme2@uncg.edu ABSTRACT: This paper considers three general views about the nature of moral obligation and three particular answers (with which these views are typically associated) concerning the following question: if on Monday you lend me a book that

https://www.fil.lu.se/hommageawlodek/site/papper/ZimmermanMichael.pdf - 2026-07-12

This article started out as a keynote lecture at the ‘Coarseness of the Brontës: A Reappraisal’ conference in Durham on 10-11 August 2017. It raises issues in which the ‘coarseness’ of The Tenant of Wildfell Hall (1848) - its most striking characteristic, according to censorious 1848 reviewers - is a central element. These issues include the violent Hattersley marriage, the manifestations of physi

By understanding laws of nature as geometrical rather than linguistic entities, this paper addresses how to describe theory structures and how to evaluate their continuity. Relying on conceptual spaces as a modelling tool, we focus on the conceptual framework an empirical theory presupposes, thus obtain a geometrical representation of a theory’s structure. We stress the relevance of measurement pr

Att silver har en bakteriedödande effekt har varit känt sedan många århundraden. Historien om silver sträcker sig ända tillbaka till 4000 år före Kristus då de antika Kaldeérna använde silver och det var på den tiden en av mest använda metallerna tillsammans med guld och koppar. Persiska kungar föredrog att dricka vatten endast från bägare gjorda av silver för att vattnet kunde bevaras friskt och Over the past decade, a massive increase in the use of nanomaterials and nanoparticles (NPs) in both commercial and medical applications has occurred. Medical applications include advanced drug delivery vehicles, imaging and hyper thermic therapies. In retinal research, several nanomaterials have been explored in novel treatment approaches, ranging from metals, carbon, polymers and silica to biolo