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Sphingosine 1-phosphate (S1P) is a signalling sphingolipid affecting multiple cellular functions of vascular and immune systems. It circulates at submicromolar levels bound to HDL-associated apolipoprotein M (apoM) or to albumin. S1P in blood is mainly produced by platelets and erythrocytes, making blood sampling for S1P quantification delicate. Standardisation of sampling is thereby of great impo

The respiratory pathogen Chlamydia (Chlamydophila) pneumoniae is associated with chronic diseases, including atherosclerosis and giant-cell arteritis, which are accompanied by the occurrence of these obligate intracellular bacteria in blood vessels. There, C. pneumoniae seems to be present in a persistent state. Persistence is characterized by modified bacterial metabolism and morphology, as well

This study describes a new method for the fixation of titanium hip stem prostheses based on interdigitation of irregularly shaped porous titanium granules onto bone tissue. The granules were distributed into the prepared femoral cavity using a vibrating tool, and the stem was vibrated and tapped into the bed of granules. In this pilot study, 5 patients were followed between 9 and 15 years. The cli

Background Ximelagatran is a novel, oral direct thrombin inhibitor under investigation as an alternative to warfarin for prevention of thromboembolism in patients with nonvalvular atrial fibrillation (AF). Two long-term studies in patients with AF and at least one additional risk factor for stroke are underway to compare the safety and efficacy of fixed-dose ximelagatran (36 mg bid) without coagu

AIMS/HYPOTHESIS: To analyse the incidence of Type I (insulin-dependent) diabetes mellitus in the 0-34 years age group in Sweden 1983-1998. METHODS: Incidence and cumulative incidence per 100 000 and Poisson regression analysis of age-period effects was carried out using 11 751 cases from two nation-wide prospective registers. RESULTS: Incidence (95%-CI) was 21.4 (20.8-21.9) in men and 17.1 (16.6-1

Immunohistochemistry has been used to demonstrate that neuropeptide Y, dopamine-beta-hydroxylase, calcitonin gene-related peptide or substance P are colocalized with vasoactive intestinal polypeptide and choline acetyltransferase in subpopulations of neurons in cranial parasympathetic ganglia of rat. These comprise the ciliary, sphenopalatine, otic, glossopharyngeal-vagal and internal carotid gang

BACKGROUND: Organic acid anhydrides (OAAs) are highly allergenic compounds used in the chemical industry. The OAAs probably act as haptens but the proteins that form conjugates with OAAs in vivo are still unknown. Conjugates between the anhydrides and serum albumins (SAs) have routinely been used when testing for OAA-specific antibodies. However, the use of SA as the carrier-protein in these tests

Denna studie syftade till att undersöka relationen mellan positivt värderade egenskaper och psykologiska och sociala faktorer i det svenska arbetslivet, på ett urval av 43 unga vuxna i åldern 19-29, med tidsbegränsad anställning. Vidare undersöktes huruvida relationen mellan dessa variabler skiljde sig åt beroende på könstillhörighet. Med positiv psykologi som teoretisk utgångspunkt genomfördes eThis study aimed to investigate the relationship between positively valued character strengths and psychological and social workplace factors in Swedish working life, on a sample of 43 young adults aged 19-29, with fixed-term employment. Furthermore, the study explored whether the relationship between these variables differed between men and women. While using positive psychology as a theoretical

Till följd av utvecklingen av Web 2.0 har konsumenterna fått en större inverkan på varumärkes marknadsföring och har nu möjligheten att integrera med andra konsumenter och marknadsfö-ringens innehåll. Marknadsförare har utvecklat en ny marknadsföringsstrategi med anledningen av den digitala utvecklingen. Denna nya strategi har fått namnet influencer marketing. Tidigare studier har först och främstDue to the development of Web 2.0 the public has the ability to interact with others regarding the content of marketing. This has led the public to having a greater impact than ever on the marketing field. In response to the changes, marketers have developed a new marketing strate-gy. The new strategy is called influencer marketing. Most previous studies of influencer market-ing have had their stu

Bakgrund: Skiftarbete inverkar negativt på individens hälsa. Sömnbesvär och begränsade möjligheter till aktiviteter är vanliga konsekvenser, men även aktivitetsmönster och aktivitetsbalans kan påverkas. Skiftarbetande sjuksköterskor riskerar sömnbesvär och en förändrad dynamik i sitt aktivitetsmönster. Syfte: Syftet med studien var att genom en litteraturöversikt kartlägga på vilket sätt skiftarbeBackground: Shift work has a negative impact on health, and sleep disorders and a lack of time for social activities are common. The occupational balance alongside occupational pattern can also be affected. Shift working nurses is one group that may be at risk. Aim: The aim of this literature review was therefore to explore how dynamics of the nurses’ occupational patterns as well as their sleep c

Denna litteraturstudie syftar till att sammanfatta den prekambriska berggrunden och dess geologiska utveckling i norra Skåne. Studien bygger på tidigare publicerat material, primärt tre av SGU:s berggrundskartor: Af 127, 155 och 181. Dessa visar berggrunden i området nordost, sydväst och nordväst om Kristianstad. För att kunna sätta in denna berggrund i ett större sammanhang har även andra publikaThis literature study aims to summarize the Precambrian bedrock and its geological development in northern Scania. The study is based on previously published material, primarily three of SGU’s bedrock maps: Af 127, 155 and 181. These show the bedrock in the area northeast, southwest and northwest of Kristianstad. In order to place this bedrock in a broader context, other publications dealing with

Projekteringsprocessen i byggbranschen är i ständig förändring. Större och mer komplicerade byggnadsprojekt med högre krav på sig blir allt vanligare. En lyckad projektering är en lyckad produktion. Detta ligger som grund till att projekteringsprocessen måste fungera på ett effektivt sätt. Enligt Nasa och Stanford university är nyckeln till en lyckad projektering att korta ned tiden mellan fråga o

Barns rättigheter har konsekvent missbrukats under väpnade konflikter. Det har skett mer än 266 000 allvarliga kränkningar av barns rättigheter mellan 2005 och 2020, även om det verkliga antalet förmodligen är högre. FN har identifierat sex allvarliga kränkningar av barns rättigheter vid väpnade konflik-ter. Avhandlingen syftar till att belysa hur upprättelse för kränkningar av de sex allvarliga kChildren’s rights have consistently been abused during armed conflicts. There have been more than 266,000 grave violations against children’s rights be-tween 2005 and 2020, even though the real number probably is higher. The UN has identified six grave violations against children’s right during armed conflict. The thesis aims to highlight how the reparation for violation of the six grave violation

Syftet med denna studie var att genom en kritisk diskursanalys utforska vilka diskurser som tar plats i kommunikationen hos svenska gymkedjor samt vilka sociala strukturer i relation till träning och fysisk aktivitet de bidrar till att skapa och/eller reproducera. Det insamlade materialet bestod av det visuella materialet på hemsidorna hos Sveriges fem största gymkedjor, vilket analyserades med hjThe purpose of this study was that through a critical discourse analysis investigate what discourses take place in the communication among Swedish gym facilities, and what social structures regarding physical activity they are currently creating and/or reproducing. The collected material consisted of the visual mate-rial presented on the webpages of the five larges gym facilities in Sweden. The ma

Detta examensarbete är ett samarbete med Region Skåne för att adressera den brist på strukturerade estimeringsmetoder som finns för projekt inom avdelningen “Digitalisering IT och MT”. Fokus har varit att skapa ett Proof of Concept (POC) i Excel som ska fungera som en grund för planering och genomförande av tester inom testavdelningen. Testprocessen i Region Skåne består av fyra faser: initiera, p

We have measured the uptake capacity of nitrogen (N) and potassium (K) from different soil depths by injecting N-15 and caesium (Cs; as an analogue to K) at 5 and 50 cm soil depth and analysing the recovery of these markers in foliage and buds. The study was performed in monocultures of 40-year-old pedunculate oak (Quercus robur), European beech (Fagus sylvatica) and Norway spruce (Picea abies (L.

This study aimed to assess the costs and benefits of three alternative second-line treatment strategies for Swedish patients with type 2 diabetes mellitus (T2DM) who fail to reach glycated hemoglobin (HbA1c) ≤ 7% with metformin treatment alone: glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and neutral protamine Hagedorn (NPH) insulin.