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Sphingosine 1-phosphate (S1P) is a signalling sphingolipid affecting multiple cellular functions of vascular and immune systems. It circulates at submicromolar levels bound to HDL-associated apolipoprotein M (apoM) or to albumin. S1P in blood is mainly produced by platelets and erythrocytes, making blood sampling for S1P quantification delicate. Standardisation of sampling is thereby of great impo
Qualitative methods are well established in music education research. This has led to an interesting body of research, each project investigating in depth a specific situation or phenomenon. One way of combining the advantages of qualitative studies with the aim of acquiring general theories Of music education might be to develop methods of re-analyzing primary studies on a secondary, meta level.
To determine if primary hand osteoarthritis (OA) is associated with abnormal bone and anthropometric traits.
OBJECTIVE: To define age-adjusted incidence trends in multiple myeloma (MM) in a well-characterized population during a long period, given that some, but not all, studies have reported increasing MM incidence over time and that clinical experience from some centers suggests an increased incidence mainly in younger age groups. PATIENTS AND METHODS: We identified all patients (N=773) with MM diagnos
The goal of this paper is to consider how the notion of analyticity can be dealt with in model-theoretical terms. The standard approach to possible-world semantics allows us to define logical truth and necessity, but analyticity is considerably more difficult to account for.
Bakgrund: I en tid med hårdnande konkurrens, där utbudet ofta är större än efterfrågan, tvingas organisationer till effektivisering. Därav har vikten av att implementera ett starkt varumärke ökat, via denna kan kunden upplysas om produkt, kvalitet samt funktion. Efter den svenska skolreformen infördes, vilket innebar att skolväsendet öppnade upp sina portar för konkurrens, har betydelsen av varumä
Lesbian, gay, and bisexual people continue to face discrimination and persecution in their daily lives, often from both the state and their communities. Where states do not provide for the basic human rights and physical security of their lesbian, gay, and bisexual citizens, many such citizens would flee their countries of origin in search of refuge in more hospitable countries. If other countries
Myanmar is the world's second-largest producer of opium poppy, the raw material from which heroin and opium are produced. 85% of this opium poppy is cultivated in rural areas of Shan State, where about 1 in 10 households in the villages are directly involved in opium poppy cultivation for the drug industry (MIMU, 2017). The economy of opium poppy permeates social and family dynamics; nonethele
In the coming decades, the twin energy and digital transitions will require the rapid scaling and deployment of renewable energy technologies and advanced technologies within ‘critical raw materials’ (CRMs) are essential components. At the same time, as CRM reserves are heterogeneously distributed, concentrated in a few countries with refining in even fewer still, demand is expected to outstrip su
In recent years, the European Union (EU) has tackled the issue of free and fair competition in digital markets by enacting a regulatory framework within a specific legislation called “The Digital Markets Act” (DMA). This recently adopted regulation lays out rules and obligations binding on digital “gatekeepers”, that is undertakings operating on digital markets that provide “core platform services
The spread of multiuse landscape worldwide has drastically increased humanwildlife interactions and especially negative impacts of wildlife on human assets. Human-wildlife interactions threaten both biodiversity conservation and farmers’ livelihood, especially in low-income areas where farming practices are their main source of income. In Zimbabwe, wildlife damage to crops and livestock creates te
Summary The t(X;7)(q22;q34), a translocation not previously reported in a neoplastic disorder, was identified and molecularly characterised in a paediatric T-cell acute lymphoblastic leukaemia (T-ALL), subsequently shown also to harbour a deletion of 6q, a STIL/TAL1 fusion and an activating NOTCH1 mutation. The t(X;7) was further investigated using fluorescence in situ hybridisation (FISH), real-t
In this study, a surface plasmon resonance (SPR) biosensor was developed for the detection and quantification of a secreted bacterial factor (RoxP) from skin. A molecular imprinting method was used for the preparation of sensor chips and five different monomer-cross-linker compositions were evaluated for sensitivity, selectivity, affinity, and kinetic measurements. The most promising molecularly i
The Okinawan-based Nordic (O-BN) diet improves anthropometry and metabolism in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to study mechanisms behind improvements by examining Enterobacteriaceae abundance, microbial diversity, and concentrations of short-chain fatty acids (SCFAs). A secondary aim was exploring if metformin treatment affects microbiota or SCFAs. Thirty T2DM
Objectives: To compare breast density measured on digital breast tomosynthesis (DBT) (BI-RADS-based breast composition and fully-automatic estimation) and magnetic resonance imaging (MRI) (BI-RADS amount of fibroglandular tissue), and to evaluate the diagnostic performance in terms of sensitivity and specificity of DBT and MRI in a predominantly dense breast population. Methods: Between 2015 and 2
