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Amplification of the HER-2/neu (HER-2) proto-oncogene occurs in 10%–15% of primary breast cancer, leading to an activated HER-2 receptor, augmenting growth of cancer cells. Tumor classification is determined in primary tumor tissue and metastatic biopsies. However, malignant cells tend to alter their phenotype during disease progression. Circulating tumor cell (CTC) analysis may serve as an altern
Introduction: Identifying factors that influence individuals' smoking behavior remains a huge public health concern. This study aimed to investigate changes in individuals' cigarette smoking while considering well-known smoking determinants, including social capital, its presence being postulated to reduce smoking. Methods: From British Household Panel Survey data, two baseline smoking cohorts wer
Multilevel data occurs frequently in many research areas like health services research and epidemiology. A suitable way to analyze such data is through the use of multilevel regression models (MLRM). MLRM incorporate cluster-specific random effects which allow one to partition the total individual variance into between-cluster variation and between-individual variation. Statistically, MLRM account
The poor survival of embryonic dopaminergic (DA) neurons transplanted into patients with Parkinson's disease (PD) has encouraged researchers to search for new methods to affect the short- as well as long-term survival of these neurons after transplantation. In several previous rodent studies Sertoli cells increased survival of islet cells and chromaffin cells when cotransplanted in vivo. The aims
The Eider Somateria mollissima is a commonbreeding species in the Baltic. In 2008, Ottossonet al. (2012) estimated that the breeding populationof Eiders in the archipelagoes of the four Swedishcounties of Kalmar, Östergötland, Södermanlandand Stockholm was in the order of 103 000 pairs,whereas the breeding population around Gotlandwas about 6000 pairs. The distribution of breedingEiders in several
Regular counts of wintering waterfowl have been undertaken as a part of the International Waterfowl Census (IWC) and the National Swedish Environmental Monitoring Program since 1964. After the first years, a network of annually surveyed sites was established for the calculation of annual indices. Country-wide surveys (also including aerial counts) were undertaken 1971–1974, 1987–1989, 1992–1993 (p
A novel liquid-liquid extraction (LLE) procedure was investigated for preparation of peptide and protein samples for matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). LLE using ethyl acetate as the water-immiscible organic solvent enabled segregation of hydrophobic and hydrophilic polypeptides in mixtures, thereby reducing the complexity of mass spectra obtained by MALDI MS
This article analyzes producer-consumer relations in social media marketing in the Swedish dairy industry. The article discusses how ideas of interspecies intimacy are publicly performed in an interactive process between the dairy industry producers and social media users. Two examples from the Swedish dairy industry were chosen for analysis: one Instagram account and one Facebook account. The ana
Bacterial plasmids are extensively involved in the rapid global spread of antibiotic resistance. We here present an assay, based on optical DNA mapping of single plasmids in nanofluidic channels, which provides detailed information about the plasmids present in a bacterial isolate. In a single experiment, we obtain the number of different plasmids in the sample, the size of each plasmid, an optica
Background: Anillin (ANLN), an actin-binding protein required for cytokinesis, has recently been presented as part of a prognostic marker panel in breast cancer. The objective of the current study was to further explore the prognostic and functional value of ANLN as a single biomarker in breast cancer. Methods: Immunohistochemical assessment of ANLN protein expression was performed in two well cha
Two-dimensional direct numerical simulation (2-D DNS) is used to investigate the effect of turbulence intensity and composition stratification on H2/air mixture auto-ignition in a constant volume enclosure relevant to homogeneous charge compression ignition (HCCI) engines. Different turbulence levels, composition fluctuations, EGR (Exhaust Gas Recirculation) ratios, initial pressure, domain length
Aim: This study investigated the relationship between sexual debut before 14 years of age and socio-demographics, sexual experience, health, experience of child abuse and behaviour at 18 years of age. Methods: A sample of 3432 Swedish high school seniors completed a survey about sexuality, health and abuse at the age of 18. Results: Early debut was positively correlated with risky behaviours, such
The removal of particulate fine fractions by a proper high-temperature cleaning device is a very important issue in the development of the biorefinery concept. Therefore, in this investigation, particles from a 100 kW(th) steam-O-2 blown circulating fluidized-bed (CFB) gasifier were sampled and characterized. The sampling was performed with a specially designed heated dilution probe downstream of
Background: The clinical presentation in progressive supranuclear palsy (PSP), an atypical parkinsonian disorder, includes varying degrees of frontal dysexecutive symptoms. Using diffusion tensor imaging (DTI) and tractography (DTT), we investigated whether diffusion changes and atrophy of the inferior fronto-occipital fasciculus (IFO) occurs in PSP and if these changes correlate with disease stag
This paper presents numerical and experimental studies on the onset and evolution of laminar cellular flames of CH4/O-2/CO2 (oxy-fuel) and CH4/air mixtures under adiabatic conditions, stabilized in the proximity of a flat-flame burner at atmospheric pressure. In the numerical simulations, a two-dimensional domain with periodicity at the transverse far field boundaries is resolved using a high accu
Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, media
