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Objectives. To assess the optimal stroke prevention treatment for patients with atrial fibrillation (AF) and a low-medium risk (<=4%) of stroke. Design. A total of 668 patients with persistent or permanent AF, without an indication for full dose and with adequate rate control on sotalol, were randomized to warfarin 1.25 mg + aspirin 75 mg daily (W/A, 334 patients) or no anticoagulation (C, 334 pa
The way relationships between symbols and thoughts are created is a general problem in learning, mainly described as "how students' learn to mean". This general problem raises some basic questions concerning how students' relate understanding to words used in learning. The present research provides an alternative perspective on the relationship between thought and language derived from the phenome
Detailed information from the Swedish National Forest Inventory was used to simulate the carbon balance for Sweden by the process-based model Biome-BGC. A few shortcomings of the model were identified and solutions to those are proposed and also used in the simulations. The model was calibrated against CO2 flux data from 3 forests in central Sweden and then applied to the whole country divided int
The first EGF-like module of human coagulation factor IX contains a single functionally important calcium ion binding site. We have now shown the dissociation constant for this site to be approximately 160 microM in a recombinant protein fragment consisting of residues 1-85 in human fIX. This represents a approximately 10-fold increase in affinity as compared with the isolated EGF module (residues
Context: Insulin-stimulated glucose uptake in skeletal muscle is mediated through translocation of the insulin-sensitive glucose transporter 4 ( GLUT4)-containing vesicles to the plasma membrane. Thus, skeletal muscle GLUT4 content plays an important role in whole-body insulin sensitivity. Objectives: The objectives of this study were 1) to examine the relative impact of genetic vs. environmental
A field sampling device to study the transport of aromatic, persistent chlorinated hydrocarbons from water to air was constructed. It was tested in large, outdoor artificial ponds contaminated with polychlorinated biphenyls (PCBs). The PCB compounds volatilised to air at a rate of 0·9 to 9·6 ng m−2 h−1 depending on levels of PCBs in the water and water temperature.
Objective. To compare antibody responses to 23-valent pneumococcal vaccine (Pneumovax (R)) in controls and patients with established rheumatoid arthritis (RA) treated with TNF blockers, methotrexate (MTX) or a combination of both. Methods. Patients with RA (n = 149) and healthy controls (n = 47) were vaccinated. Treatment with TNF blockers (etanercept or infliximab) and MTX was given to 50 patient
An experimental design was used to determine optimal conditions for refolding of a recombinant thermostable and alkaline active xylanase from Bacillus halodurans in PEG-phosphate two-phase system. The influence of different experimental variables on the enzyme recovery has been evaluated. To build the mathematical model and minimize the number of experiments for the design parameters, response sur
Objectives: There is epidemiologic evidence that the consumption of fried, grilled or barbecued meat and fish that are well-done or browned may be associated with an increased cancer risk. These high-temperature cooking methods are thought to be surrogates for mutagens and carcinogens produced in meat and fish, eg heterocyclic amines or polycyclic hydrocarbons. Since data on food cooking methods a
The effects of the chaotrophic anion perchlorate (ClO4-) on glucose-induced electrical activity, exocytosis and ion channel activity in mouse pancreatic B-cells were investigated by patch-clamp recordings and capacitance measurements. ClO4- stimulated glucose-induced electrical activity and increased the action potential frequency by 70% whilst not affecting the membrane potential when applied in
Aims: Life expectancy in Sweden is among the highest in the world, and the province of Halland has the highest life expectancy in Sweden today. In an earlier paper the authors reported that life expectancy in the province of Halland in the south-west of the country was approx. 3.5 years above the national average between 1911 and 1950. The aim of this study was to explore the influence of differen
Popular Abstract in Swedish Denna avhandling är ett resultat av ett doktorandprojekt vid Kvartärgeologiska avdelningen, Lunds Universitet. Syftet med avhandlingen har varit att utröna huruvida bildningen av kalktuff i Sverige har varit beroende av klimatet samt under vilka tider och i vilken närmiljö tuffen bildats. I samband med under-sökningen har ett stort antal landsnäckor påträffats och analyAlthough deposition of freshwater calcium carbonates, tufa, has occurred in large areas with carbonate soil or bedrock in Sweden, no tufa formation has been observed in Sweden. To better understand the factors controlling tufa formation in southern Sweden, bio- and lithostratigraphical studies were carried out on (paludal) calcareous tufa deposits in the province of Skåne. The biostratigraphical m
Microsomal membrane preparations from the immature cotyledons of safflower (Carthamus tinctorius) catalysed the interconversion of the neutral lipids, mono-, di-, and triacylglycerol. Membranes were incubated with neutral lipid substrates, 14C-labelled either in the acyl or glycerol moiety, and the incorporation of radioactivity into other complex lipids determined. It was clear that diacylglycero
The δ13C chemostratigraphy of five of the seven Ordovician global stages has been published previously but no such data have been available from the Floian GSSP and most of the Sandbian GSSP in Sweden. This lack of information has now been remedied by isotope data obtained from series of closely spaced shale samples collected from the Floian stratotype at Diabasbrottet in Västergötland and the San
Introduction Half of all Ugandans (49%) turn to the private or private-not-for-profit (PNFP) sectors when faced with illness, yet little is known about the capacity of these sectors to deliver surgical services. We partnered with the Ministry of Health to conduct a nationwide mixed-methods evaluation of private and PNFP surgical capacity in Uganda. Methods A standardized validated facility assessm
