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Rho-kinase signaling regulates important features of inflammatory reactions. Herein, we investigated the effect and mechanisms of action of the Rho-kinase inhibitor fasudil in endotoxemic liver injury. C57/BL/6 mice were challenged with lipopolysaccharide (LPS) and D-galactosamine, with or without pretreatment with the Rho-kinase inhibitor fasudil. Six hours after endotoxin challenge, leukocyte-en

BACKGROUND: Different P-wave morphologies during sinus rhythm as displayed on standard ECGs have been postulated to correspond to differences in interatrial conduction. OBJECTIVE: The purpose of this study was to evaluate the hypothesis by comparing P-wave morphologies using left atrial activation maps. METHODS: Twenty-eight patients (mean age 49 +/- 9 years) admitted for ablation of paroxysmal at

A Gla domain-mutated protein C variant, QGNSEDY, modified at positions 10-12, 23, 32-33, and 44, having enhanced affinity for negatively charged phospholipid and increased anticoagulant potential, was used to elucidate the importance of the interaction between the Gla domain and the phospholipid for the ability of activated protein C (APC) to inactivate factor Va (FVa). FVa degradation by wild typ

This study examined the influence of insulin and glucose on the transcapillary fluid absorption during lower body negative pressure (LBNP) in humans. Ten healthy males [23 (1) years] were exposed to LBNP of 45 cmH(2)O on two occasions: (1) before and during a hyperinsulinaemic clamp (HI) and (2) before and during a hyperglycaemic clamp (HG). Transcapillary fluid absorption and blood flow were reco

OBJECTIVE: To explore the effects of MgSO4 in combination with glucose, insulin, and potassium (GIK) on intrinsic AV-nodal properties during chronic atrial fibrillation. METHODS: The study included two patient groups--(a) control and intervention and (b) intervention--with different infusion times and concentrations of MgSO4. Ambulatory electrocardiographic recordings were analyzed using modified

Varved lake sediments can be used to set multiple environmental proxies within a calendar year time scale. We undertook a systematic survey of lakes in the Province of Varmland, west central Sweden, with the aim of finding continuous varved lake sediment sequences covering the majority of the Holocene. In Fennoscandia, such sediments have previously only been recorded in northern Sweden and in sou

Environmental enrichment (EE) alleviates sensorimotor deficits after brain infarcts but the cellular correlates are not well-known. This study aimed to test the effects of postischemic EE on neocortical cell genesis. A neocortical infarct was caused by distal ligation of the middle cerebral artery in adult spontaneously hypertensive rats, subsequently housed in standard environment or EE. Bromodeo

This study aimed at evaluating the possibility of predicting septicemia in burn patients by using wound surface and tissue culture techniques as well as blood cultures. Fifty patients with full-thickness burn wounds covering at least 10% of the total body surface area were included. Signs of septicemia were noted in 21 patients (42%) and 29 patients died (58%). The bacterial colonization of the bu

Climatic warming leads to the expansion of deciduous shrubs and trees in the Arctic. This leads to higher leaf litter inputs, which together with warming may alter the rate of carbon and nutrient cycling in the arctic ecosystems. We assessed effects of factorial warming and additional litter on the soil ecosystem of a subarctic heath in a 7-year-long field experiment. Fine root biomass, dissolved

Cerebral ischemia results in enhanced expression of smooth muscle cell endothelin and angiotensin receptors in cerebral arteries. We hypothesise that this phenomenon may be detrimental and that acute treatment with a combined non-hypotensive dose of the angiotensin AT, receptor inhibitor candesartan and the endothelin ETA receptor antagonist ZD 1611 reduces the infarct in experimental ischemic str

Background: Helicobacter pylori causes peptic ulcer disease and gastric cancer, and the oral cavity is likely to serve as a reservoir for this pathogen. We investigated the binding of H. pylori to the mucins covering the mucosal surfaces in the niches along the oral to gastric infection route and during gastric disease and modeled the outcome of these interactions. Materials and Methods: A panel o

Language cultivation and grammars in Sweden and Denmark 1550-1800.

The memory of the The Liberation of Bergen-Belsen and the White Buses has been vivid both i Great Britain and in Sweden. The question is how the memories have looked like and who´s been classified as heroes in different times.

Popular Abstract in Swedish Inledning och hypotes Urininkontinens är ett vanligt förekommande tillstånd som förorsakar sänkt livskvalitet hos individen och dessutom stora kostnader för samhället. Förekomsten i befolkningen beror på hur snävt man definierar begreppet och är följaktligen mycket skiftande i olika undersökningar. Urininkontinens är ett symptom på en sjukdom eller ett tillstånd, inte eUrinary incontinence classification is based on symptomatology, presuming that each symptom originates in a separate pathophysiology and demands its unique therapy. Women often present a mixture of symptoms inconsistent with urodynamic diagnosis, especially regarding urgency. Treatment of stress incontinence often relieves urge symptoms indicating a common pathophysiology. Our aims were to investi

Popular Abstract in Swedish Växter påverkar marken rent mekaniskt genom att jordstrukturen ändras när en rot växer, men också kemiskt genom att rötterna utsöndrar organiska molekyler. De organiska molekylerna ökar näringstillgången för mikroorganismerna i marken och därmed ändras tillväxthastigheten och biomassan hos mikroorganismerna. I området runt rötter, rhizosfären, råder det därför en hög miMicrobial activity in soil is generally assumed to be limited by carbon availability. The soil closest to roots, the rhizosphere, is therefore a zone of high microbial activity due to carbon containing substances released by the root. In this work short-term effects in the rhizosphere have been the subject of investigation. I have shown that the thymidine and leucine incorporation techniques are w