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Objective: The class II transactivator (CIITA), encoded by the CIITA gene, controls expression of immune response regulators, which affect bone homeostasis. Previously, we investigated a functional CIITA polymorphism in elderly women. Women carrying the allele associated with lower CIITA levels displayed higher bone mineral density (BMD), but also higher bone loss. The present exploratory study in
Background and purpose — Concerns exist regarding the generalizability of results from randomized controlled trials (RCTs) evaluating arthroscopic partial meniscectomy (APM) to treat degenerative meniscus tears. It has been suggested that study populations are not representative of subjects selected for surgery in daily clinical practice. There-fore, we aimed to compare patients included in trials
Background: Newborn infants undergoing therapeutic hypothermia (TH) are exposed to multiple painful and stressful procedures. The aim of this systematic review was to assess benefits and harms of pharmacological and non-pharmacological interventions for the management of pain and sedation in newborn infants undergoing TH for hypoxic-ischemic encephalopathy. Methods: We included randomized and obse
Background: There is limited information on the distribution of retroperitoneal lymph node metastases (LNMs) in upper tract urothelial carcinoma (UTUC). Objective: To investigate the location of LNMs in UTUC of the renal pelvis or proximal ureter and short-term complications after radical nephroureterectomy (RNU) with lymph node dissection (LND). Design, setting, and participants: This was a prosp
This Letter reports the observation of τ-lepton-pair production in ultraperipheral lead-lead collisions Pb+Pb→Pb(γγ→ττ)Pb and constraints on the τ-lepton anomalous magnetic moment a_{τ}. The dataset corresponds to an integrated luminosity of 1.44 nb^{-1} of LHC Pb+Pb collisions at sqrt[s_{NN}]=5.02 TeV recorded by the ATLAS experiment in 2018. Selected events contain one muon from a τ-lepton dec
Transitioning to net-zero carbon emissions requires phasing-out unabated coal power; however, recently it has only been declining in some countries, while it stagnated or even increased in others. Where and under what circumstances, has coal capacity reached its peak and begun to decline? We address this question with an empirical analysis of coal capacity in 56 countries, accounting for 99% of co
BACKGROUND: Ketamine has considerable therapeutic potential in alleviating major depressive disorder and chronic suicidality. However, the clinical diagnosis of neuropsychiatric disorders requires more robust diagnostic criteria. Electroencephalography (EEG) has shown promise in classifying depressive and suicidal patients from healthy individuals. The present study aimed to identify changes in th
The newly emerged pathogen, Candida auris, presents a serious threat to public health worldwide. This multidrug-resistant yeast often colonizes and persists on the skin of patients, can easily spread from person to person, and can cause life-threatening systemic infections. New antifungal therapies are therefore urgently needed to limit and control both superficial and systemic C. auris infect
Osteoarthritis (OA)-related meniscal degeneration involves complex interactions between oxidative stress and proteasomal dysfunction. However, the molecular drivers of regional meniscal vulnerability remain poorly defined. This study integrated multiple transcriptomic datasets from OA and control menisci to identify functional networks and hub genes by using weighted gene co-expression network ana
In this report, we present findings from a Swedish Universities of the Built Environment (SBU) project (2023) where we collected and synthesized examples of pedagogic tools used to strengthen students’ conceptual understanding in structural engineering—i.e., understanding key structural concepts, how they relate to each other, and how they connect to real-world structures and practice. The project
Evidence is limited for the association between parental income during childhood and adolescence and the subsequent risk of drug use disorder (DUD) in the second generation and whether the association is modified by region of origin. Identifying the association and effect modification by immigrant background and region of origin would provide an important knowledge base to consider tailored polici
Problem: Inter Agency Procurement Services Office (IAPSO) is an office within United Nations Development Programme (UNDP) that handles procurement for governments, non-governmental organizations (NGO's), United Nations agencies, international finance institutions etc. Annually all UNDP offices and organizations are measured for performance and customer satisfaction in a quantitative Bureau of
Few studies on sickness absence, theoretical as well as empirical, in the field of economics specifically focus on the impact of chronic illness. The purpose of the present study is to fill this theoretical gap by providing a theoretical explanation of sickness absence after the onset of a specific chronic illness, namely type 1 diabetes, but also to empirically examine if sickness absence differs
The trademark term has grown and evolved with time. Promoting phrases, i.e. slogans, are one type of mark that may be protected through trademark law. However, this process has not been simple. The inherent characteristics of slogans have caused great hesitation regarding their protection. Slogans consist of a number of words, sometimes full sentences, and often, include advertising messages. Can
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This essay analyzes the importance of music and dancing in Jane Austen's early novels. This is done by looking at a series of musical pastimes that were popular in the 18th century. The essay also provides an overlook of the musical period of the time.
