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Prevention is viewed as a key issue for general practice, yet there is a lack of evidence regarding general practitioners’ interventions in both middle-aged and elderly people. This is despite the fact that recommendations and key indicators for monitoring the use of clinical preventive strategies aimed at these groups are available and that both the World Health Organization and European Commissi

It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected,

Objective: To investigate how subjective perceptions of everyday occupations, activity level, day centre attendance, social interaction, self-mastery and clinical factors were related to how unemployed people with psychiatric disabilities (PD) envision a future worker role, also controlling for socio-demographic variables. Participants: 175 people with PD; 93 attended a day centre and 82 did not.

The mechanism behind the adjuvant effect of aluminum salts is poorly understood notwithstanding that aluminum salts have been used for decades in clinical vaccines. In an aqueous environment and at a nearly neutral pH, the aluminum salts form particulate aggregates, and one plausible explanation of the lack of information regarding the mechanisms could be the absence of an efficient method of trac

Raw milk may be a risk for public health if it is contaminated with zoonotic pathogens. To study the prevalencein unpasteurized milk from Swedish farms, bovine and small ruminant dairy farms were sampled. Since thesampling method and transport conditions may influence the outcome of analyses, efforts were made to optimizethe methodology. Culturing of bacteria was done from in-line milk filters col

Introduction: Product-oriented environmental law is an expanding, poly-thematic subsection of environmental law. First, an increasing number of policy instruments are being used at the international, European and national levels to regulate products, including mandatory performance standards, consumer subsidies, public procurement practices, product bans, taxes and charges and various kinds of man

Some strains of the bacterial pathogen Streptococcus pyogenes secrete protein SIC (streptococcal inhibitor of complement), including strains of the clinically relevant M1 serotype. SIC neutralizes the effect of a number of antimicrobial proteins/peptides and interferes with the function of the host complement system. Previous studies have shown that some S. pyogenes proteins bind and modulate coag

Popular Abstract in Swedish Mer än hälften av alla kvinnor har haft en urinvägsinfektion. Infektionen uppkommer när bakterier når urinblåsan och börjar växa. Immunförsvaret känner igen bakterierna, reagerar med en inflammation och symptom som sveda, trängningar och smärtor i nedre magtrakten uppstår. Om bakterierna klättrar upp till njurarna sprider sig inflammationen dit och orsakar ryggsmärtor oUrinary tract infections (UTIs) present an interesting and relevant model for studying microbial adaptation. After establishing significant numbers, the bacteria either cause severe disease, or an asymptomatic carrier state resembling the normal flora at other mucosal sites. Patients with asymptomatic bacteriuria (ABU) are protected from re-infection if the strain that they carry outcompetes more

The aim of this study was to investigate associations between time use in daily activities and sociodemographic and clinical factors in order to identify individuals with persistent mental illness at risk of having an imbalance in daily activities, as reflected in their time use and daily rhythm. Participants (n=103) were selected from a psychiatric outpatient unit using a randomized stratified se

Plasma cystatin C is increasingly used as a marker of glomerular filtration rate. Most assays for cystatin C are based on turbidimetric or nephelometric detection and studies of other rapid methods are limited. This study aimed to develop and compare differently configured immunoassays for quantification of plasma cystatin C, using recombinant cystatin C and two cystatin C-specific antibodies. Met

The ubiquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negative regulators of NF-kappa B signaling. Both can act by removing nonproteolytic K63-linked polyubiquitin chains from an overlapping set of signaling molecules. In B cells, A20 deficiency results in hyperactivity, loss of immune homeostasis, inflammation, and autoimmunity. The reported consequences of CYLD defic

Learning from incidents is considered a very important source for learning and improving safety in the process industries. However, the effectiveness of learning from reported incidents can often be ques-tioned. Therefore, there is a need to be able to evaluate the effectiveness of learning from incidents, and for that purpose we need methods and tools. In this paper, a method is described for eva

Popular Abstract in Swedish Inledningen till avhandlingens första kapitel tar avstamp i en diskussion om normativa (hur man bör göra) och deskriptiva (hur man faktiskt går tillväga) förhandlingsteorier. Normativa teorier bygger på antaganden om att människor kan och vet i stort sett allting och de ger råd om hur man bör göra. De deskriptiva förhandlingsteorierna försöker förklara hur människor fakScholars within the Process school assume that cognitive and motivational aspects within the decision and integration processes may systematically effect the outcome of mergers and acquisitions. More specifically, it has been suggested that decision makers use heuristics for simplifying information processing which may introduce bias. The main aim of the present thesis is to add to the understandi

AIM: To assess the prognostic value of amplitude integrated EEG (aEEG) 3 and 6 hours after birth. METHODS: Seventy three term, asphyxiated infants were studied (from two different centres), using the Cerebral Function Monitor (CFM Lectromed). The different aEEG tracings were compared using pattern recognition (flat tracing mainly isoelectric (FT); continuous extremely low voltage (CLV); burst-supp

Automatic knowledge discovery from texts (KDT) is proving to be a promising method for businesses today to deal with the overload of textual information. In this paper, we first explore the possibilities for KDT to enhance communication in virtual communities, and then we present a practical case study with real-life Internet data. The problem in the case study is to manage the very successful vir