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Newly diagnosed breast cancer (BC) patients with clinical T1–T2 N0 disease undergo sentinel-lymph-node (SLN) biopsy, although most of them have a benign SLN. The pilot noninvasive lymph node staging (NILS) artificial neural network (ANN) model to predict nodal status was published in 2019, showing the potential to identify patients with a low risk of SLN metastasis. The aim of this study is to ass
Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross-species transcriptomics to show that RORγt+ DCs are a co
Youth anxiety disorders are common and heterogeneous. The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered tool designed to assess overall anxiety severity, independent of specific symptoms. The thresholds on PARS for the reliable change index (RCI), the minimal clinically important difference (MCID), treatment response, and full and partial remission remain unclear. Using the Cli
Minimizing insecticide use, preventing vector diseases and facilitating biodiversity assessments are suitable applications of recent advances in photonic insect surveillance and entomological lidar. The tools also comprise a new window into fundamental aspect of the fascinating life and ecology of insects and their predators in situ. At the same time, it is evident that lidars are subject to finit
There is a consensus among tinnitus experts to not recommend hearing aids for tinnitus patients with subclinical hearing impairment. However, this notion is arbitrary, as no previous study has compared the treatment effect of hearing aids on tinnitus distress in patients with and without clinical hearing impairment. In this article, we investigate whether tinnitus patients with clinical and subcli
We are surrounded by various chemicals, both naturally occurring and synthetically produced. Some, but not all, chemicals can be hazardous for human health following exposure, especially for vulnerable population groups including children, adolescents, and pregnant women. The increased use and production of chemicals have contributed positively to society in numerous ways, while also resulting in
Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cell
A woman’s right to make informed and autonomous decisions regarding her reproductive health is protected by international treaties and Guatemalan law. This thesis explores the factors influencing how far women in Paso Caballos, Guatemala, enjoy this right and answers the following question: What factors influence women in Paso Caballos’ possibility to make informed and autonomous decisions regardi
Violence against women and girls (VAWG) is a serious human rights issue that demands urgent action. Current standard practices increasingly focus on primary prevention; that is, to prevent violence before it occurs. The aim of this study was to enhance the knowledge on VAWG primary prevention within the social work field in a local Argentinian context - Lanús Municipality - through the model of pr
“Only in the most technical sense is this a case about who may penetrate whom where. At a practical and symbolical level it is about the status, moral citizenship and sense of self-worth of a significant section of the community.” Justice Albie Sachs, National Coalition for Gay and Lesbian Equality and Another v Minister of Justice and Others 1999 (1) SA 6, para. 107 More than 70 years after th
Genom reformen en modernare rättegång gjordes möjligheten för parter att närvara vid domstolssammanträden via ljud- och/eller bildöverföring permanent. Användningen av sådana lösningar har ökat under de senaste åren och accelererades av covid-19-pandemin. I experimentell miljö har det återkommande observerats att vittnens och målsägandes utsagor uppfattas som mindre tillförlitliga om de presenterThrough the reform en modernare rättegång [a more modern trial] the possibility for parties to attend court hearings via video and/or audio was made permanent. The use of such solutions has increased over the last years and was accelerated by the covid-19 pandemic. In experimental settings it has repeatedly been observed that witnesses’ and complainants’ testimonies are perceived as less credibl
The discourse on Business and Human Rights (BHR) has evolved substantially over the past two decades, particularly since the adoption of the UN Guiding Principles on Business and Human Rights (UNGPs) in 2011. While the UNGPs established the corporate responsibility to respect human rights through Human Rights Due Diligence (HRDD), their voluntary nature has resulted in fragmented implementation an
Gender-based violence (GBV) remains a pressing public health challenge in South Africa, deeply rooted in intersecting social, economic, and structural factors. Comprehensive approaches are increasingly recognized as essential for addressing the complex nature of the issue. While efforts to prevent GBV among children and adolescents can yield long-term, sustainable outcomes, they often remain fragm
This paper examines the effect of the recurrent tax on immovable property on wealth distribution. It also investigates how the wealth distributive effect of property prices is affected by the homeownership rate in a country. Data on the mean to median wealth ratio, tax sizes, property prices, homeownership rate, and economic freedom of 36 OECD member countries over the years 2000-2021 are used to
Since we as architects have an influence on people‘s everyday routines in their homes, it is important to understand the most natural human needs in order to create spaces for a healthy and joyful life, which are strongly connected to the environment. The human body is a complex organism which is strongly influenced by its immediate surroundings, whilst responding with circadian rhythms to the eve
From both a legal and business perspective, it is important for credit institutes to accurately assess the risk of default for potential borrowers. This is traditionally done using statistical methods, such as logistic regression or decision trees, utilising sociodemographic and credit history information.This thesis investigates whether a bureau score, provided by a credit bureau, should be incor
