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The theoretical findings of the thesis is composed of three parts, it consists of (i) a framework for social entrepreneurship, (ii) some pitfalls and success factors and (iii) a perspicuous design guide. These findings was a result of field research during a long time – more than 5 years, 2000-2005 – and the scientific purpose was to give a broad description and understanding of the research probl
Popular Abstract in Swedish Graviditetsdiabetes (GD) är en sjukdom utan någon allmänt erkänd definition och vars prognos för kvinnan och hennes foster/barn är omdiskuterad. Därför har det från etisk synpunkt ifrågasatts om man verkligen ska försöka identifiera den. Rapporter har dock angivit ökad risk att få stora barn för tiden och ökad perinatal dödlighet vid graviditetsdiabetes samt att dessa kGestational diabetes (GD) is still a nonentity disease. There is no worldwide consensus how to define it or whether it is harmful to the woman or fetus. Therefore, from an ethical point of view, it is uncertain whether one should try to identify it. Since 1991, all pregnant women in Lund are offered a 75g oral glucose tolerance test (OGTT) at 27 – 28 weeks of pregnancy. In Sweden, the definition o
Popular Abstract in Swedish Vi blir alla förkylda, får influensa eller magsjuka någon gång då och då. Smittsamma sjukdomar orsakas av patogener, d.v.s. virus, bakterier eller andra typer av parasiter. De flesta patogener som vi kommer i kontakt med tas om hand av vårt effektiva immunförsvar och vi märker i bästa fall inte av smittan. Huruvida vi blir sjuka eller inte när vi utsätts för smitta, berThe Major Histocompatibility Complex (Mhc) genes are crucial for the recognition of self and non-self peptides by the immune defence system. They are extremely variable in most studied vertebrate species. I have studied the extent and the importance of Mhc variation in Atlantic salmon (Salmo salar), mainly from the Baltic Sea. Levels of Mhc heterozygosity in hatchery populations of salmon were bet
A calibration model was developed for a non-invasive blood glucose sensor, to determine how the blood glucose data measured by this sensor is related to blood glucose data measured with laboratory capillary finger sticks and to corrupting noise. The variability of calibration models for different patients was analyzed as well as the dynamics of the non-invasive blood glucose sensor according to re
Genetic segregation analysis between NOD and C57BL strains have been used to identify loci associated with autoimmune disease. Only two loci (Cia2 and Cia9) had earlier been found to control development of arthritis, whereas none of the previously identified diabetes loci was of significance for arthritis. We have now made a high-powered analysis of a backcross of NOD genes on to the B10.Q strain
Antigenic variation in microbial surface proteins represents an apparent paradox, because the variable region must retain an important function, while exhibiting extensive immunological variability. We studied this problem for a group of streptococcal M proteins in which the similar to 50-residue hypervariable regions (HVRs) show essentially no residue identity but nevertheless bind the same ligan
The basis of a new non-destructive method for concrete pavements is described. The method uses a hybrid approach that combines frequency domain (impact-echo) and time domain (seismic) data. The equipment and data interpretation for the hybrid approach are described. The dynamic response data are interpreted in terms of guided plate wave (Lamb wave) theory, which are shown to follow the S, Lamb mod
Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant i
The use of trimethylsilyl (TMS)-derivatisation for determining muramic acid in environmental and clinical samples by gas chromatography-mass spectrometry provides high detection sensitivity; however, questions have been raised as concerns the chemical structure of the entity giving the strong signal of m/z 185. In the present communication we present evidence that this entity results from the form
The Moraxella catarrhalis IgD-binding protein (MID) has a unique specificity for human IgD, and the sequence with maximal IgD binding is located within the amino acids MID962-1200. In the present paper, we examined the MID binding site on IgD using a series of recombinant Ig. Full-length IgD, IgD F(ab')(2), and an IgD F(ab') C290R mutant lacking the inter-heavy-chain cysteine 290 were manufactured
Antibody-based microarray is a novel technology with great promise within high-throughput proteomics. The tremendous complexity of all proteomes will, however, pose major technological challenges, especially when targeting low-abundant analytes that remains to be resolved. In this paper, we have shown that antibody microarrays readily could be used for screening of low-abundant low molecular weigh
Background. The conventional treatment for poststernotomy mediastinitis usually involves surgical revision, closed irrigation, or reconstruction with omentum or pectoral muscle flaps. Recently, vacuum-assisted closure has been successfully used in poststernotomy mediastinitis. The aim of the present study was to compare the clinical outcome and survival in 101 patients undergoing vacuum-assisted c
The increasing number of bacterial genomes in combination with reproducible quantitative proteome measurements provides new opportunities to explore how genetic differences modulate proteome composition and virulence. It is challenging to combine genome and proteome data as the underlying genome influences the proteome. We present a strategy to facilitate the integration of genome data from severa
In this thesis the strategic behaviour of the three operators (Televerket/Telia, PTT Telecom and BT) on strong technological development and deregulation of the business during a period of fifteen years have been described, interpreted and analysed. Some thirty more operators have also been investigated in this respect - however not in depth. The strategic behaviour of the operators have been comp
Popular Abstract in Swedish Kroniska bensår utgör en av våra folksjukdomar, där 1% av befolkningen någon gång drabbas. Uppkomsten av sår kan ha en mängd olika orsaker. Den största gruppen är venösa sår, dvs sådana som orsakats av vensjukdom. Behandling av sår har i långa tider betraktats som komplicerad, då såren ofta varit svårläkta och återkommit efter läkning. För den enskilde patienten innebärWound management in primary and community care was investigated throughout a period of 12 years within a well-defined population in one county in Southern Sweden. The estimated prevalence of chronic leg and foot ulcers was 0.19% in 1998 and the mean prevalence was 0.20% during the years 1994-1998. Venous ulcers were the most common (38%) and 7% of the nurses’ workload was devoted to ulcer care. Du
The type of mixed mode fracture, which is of a main interest for concrete, is a type of fracture, where shear as well as tensile stresses act in a damage zone, which has been created due to pure tensile stresses, and which is perpendicular to the direction of these stresses. While this damage zone still transfers tensile stresses, a shear deformation takes place, which also causes shear stresses.
Corporate mergers and acquisitions (M&As) have during the last decade established themselves as prominent tools for corporate strategy. Consequently, more and more organizations direct their attention towards the potential benefits of a corporate merger and acquisition (M&A) and the problems of leveraging the potentials. This thesis addresses information systems (IS) integration in the con
The aim of this short paper is to present an ongoing joint research project, Human Factors in Air Navigation Services (HUFA), between the Swedish Civil Aviation Administration and Lund University. Results from the study will only be given very briefly. The project focuses on human and organizational factors and safety in air traffic control.
