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Background: Long-term survival after lung transplantation is significantly shorter compared with other solid organ transplantations. Chronic lung allograft dysfunction (CLAD), including bronchiolitis obliterans syndrome (BOS), remains the major barrier to survival. CLAD is diagnosed according to ISHLT's guidelines: a 20% drop in FEV1 using spirometry for CLAD grade 1. Given the difficulties of con
In order to identify cellular factors that regulate human papillomavirus type 16 (HPV16) gene expression, cervical cancer cells permissive for HPV16 late gene expression were identified and characterized. These cells either contained a novel spliced variant of the L1 mRNAs that bypassed the suppressed HPV16 late, 5'-splice site SD3632, produced elevated levels of RNA-binding proteins SRSF1 (ASF/SF
This thesis deals with the enforcement of intellectual property rights as an abuse of dominance. In particular after refusal to license a patent, which is essential for a standardized technology. Seeking for injunction relief may in some circumstances violate applicable competition law. The analysis will provide a hint, whereas patent holder who is dominating in particular market can or should be
Streptococcus pyogenes, gives rise from mild skin infections and pharyngitis, to life threatening infections like bacteraemia, cellulitis, puerperal sepsis, meningitis, pneumonia, necrotizing fasciitis (NF), and streptococcal toxic-like shock syndrome (STSS), or nonsuppurative sequelae, rheumatic fever and glomerulonephritis. In 2002, the first multinational network for invasive GAS disease survei
Physiological and psychosocial factors might contribute to differences in weight loss, eating behaviour and health-related quality of life (HRQoL) after bariatric surgery. The aim of this study was to investigate how perceived control over eating changes after bariatric surgery and whether it affects outcome in super-obese patients. In a retrospective analysis of a prospective study (n = 60), 49 p
Alternative macrophage activation is implicated in diverse disease pathologies such as asthma, organ fibrosis, and granulomatous diseases, but the mechanisms underlying macrophage programming are not fully understood. Galectin-3 is a carbohydrate-binding lectin present on macrophages. We show that disruption of the galectin-3 gene in 129sv mice specifically restrains IL-4/IL-13-induced alternative
The arterio-venous anastomoses (AVA) play a major role in the blood circulation in the peripheral body parts. In this work, the segmental bioheat model of Salloum et al. [1] is improved to accurately predict skin blood flow rate in the hands and fingers, and the local and overall human thermal responses in transient environments. The improvements in the model include: 1) extending the artery tree
Projekt Trapphuset Rosengård, Malmö, inleddes i maj 2008 och avslutades i april 2010. Projektet är en efterföljare till projekt Trappan, som pågick under perioden februari 2006 till juni 2007. Båda projekten har byggt på samarbete med AUC/AIC Rosengård och ABF/ABL Malmö, samt finansierats av medel från Europeiska Socialfonden och medfinansierats av Malmö Stad. Den här utvärderingsrapporten avser d
Popular Abstract in Swedish Könshormon påverkar tarmrörelser Många av kroppens funktioner styrs av hormoner. Att hormoner som vi i första hand förknippar med fortplantning också skulle kunna spela en avgörande roll för tarmfunktion är dock en relativt ny upptäckt. Få saker är så viktigt för en människas välbefinnande som en välfungerande magtarmkanal. De flesta av oss tänker inte på att frukostfrThis thesis explores the relation between gonadotropin-releasing hormone (GnRH) and gastrointestinal symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), impaired gastric emptying (IGE), and inflammatory and serological features were studied. Forty-three
Popular Abstract in Swedish Det senaste decenniet har resistansen mot antibiotika ökat enormt och visat sig vara ett stort problem för många människor runt om hela världen. Överanvändning av antibiotika i maten, jordbruket och den farmaceutiska industrin har resulterat i en epidemi av infektioner som är resistenta mot nuvarande antibiotika och blir allt svårare att behandla. I och med att människoAntibiotic resistance is now a large threat with worldwide agreement that we will fall into a post-antibiotic era unless there is suitable treatment alternatives discovered. In recent years, chronic wounds have become a major burden on society and treatment is complicated. Honey has been widely used as a topical treatment for wounds yet there is much discourse between studies examining its effect
At the beginning of the 21st Century, Zen Buddhism is no longer an unknown religion in the West. Zen-meditation enjoys great popularity, the books regarding the subject are among the bestsellers and the auditoriums are crowed if the topic concerns the bringing home of Zen Buddhism to a Western audience. At the same time Zen Buddhism today is by no means merely the religion of Zen Buddhists, but pr
During atrial fibrillation (AF), time-frequency analysis of atrial signal has been applied to describe fibrillatory frequency trends. Recently, temporal changes in spectral shape have been investigated using the spectral profile technique. This profile is computed recursively by fitting each short-time log-spectrum to a spectral template, using amplitude scaling and frequency shifting. The purpose
Background: A study was undertaken to investigate the sociodemographic distribution of workplace exposure to environmental tobacco smoke (ETS) in a Swedish working population sample. Methods: 8,270 individuals were assessed by questionnaire in the Scania Public Health Survey. The influence of sociodemographic factors on ETS exposure at work was investigated by multivariable regression analysis. Re
Popular Abstract in Swedish I »operatörens blick« beskrivs ett projekt där möjligheter för IT-stöd i erfarenhetsöverföring undersökts inom ett område där konfrontationen mellan datorisering och yrkeskunnande är särskilt tydlig - operatörsarbete i processindustrin. Driftsstörningar av olika omfattning är ett kontinuerligt inslag i operatörsarbetet och snabba förändringar i risknivå är en central deStudies in process control automation show that manual control skills are important in handling situations where the automatic control system fails. The fact that these skills are particularly difficult to maintain and develop in automated production environments is usually described as one of the ironies of automation. This work explores new roles for computer support in developing and maintainin
UNLABELLED: Pectobacterium brasiliense ( Pbr) is known to be one of the most virulent Pectobacterium species and is generally widely distributed across the globe, especially known for causing soft rot in potato-tubers and black leg in potato-plants. Currently no treatment mechanism exists, and many studies have focused on alternative treatment approaches such as biocontrol agents. Several stu
ObjectivesTo compare head acceleration between blind football players and non-disabled football players, and between anticipated and unanticipated conditions in blind football players.DesignLaboratory-based exploratory study.MethodsParticipants were ten football players (five blind football, five non-disabled; 80% female). Standardized head perturbations were applied in flexion, extension, lateral
Most clinical laboratories measure total magnesium (tMg) which includes both the ionized (iMg) and bound forms. Only the ionized component is biologically active, and it may be influenced by acid-base status, plasma protein concentrations and electrolyte disturbances, potentially altering how well tMg reflects iMg. This multicenter observational study evaluated the relationship between tMg and iMg
Hydrides GdGaHx were obtained by exposing the Zintl phase GdGa with the CrB structure to a hydrogen atmosphere at pressures from 1.5 to 50 bar and temperatures from 50 to 500 °C. Structural analysis by powder X-ray diffraction suggests that conditions with hydrogen pressures in a range between 15 and 50 bar and temperatures below 500 °C afford a uniform hydride phase with the NdGaH1.66 structure (
