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OBJECTIVE: To explore whether a prime-boost vaccination strategy, i.e., a dose of pneumococcal conjugate vaccine (PCV) and a dose of 23-valent polysaccharide vaccine (PPV23), enhances antibody response compared to single PCV dose in patients with inflammatory rheumatic diseases treated with different immunosuppressive drugs and controls. METHODS: Patients receiving rituximab (n = 30), abatacept (n
There have been increasing theoretical speculations and observational indications that certain globular clusters (GCs) could contain a sizeable population of stellar mass black holes (BHs). In this paper, we shortlist at least 29 Galactic GCs that could be hosting a subsystem of BHs (BHS). In a companion paper, we analysed results from a wide array of GC models (simulated with the MOCCA code for c
Abstract: While numerous efforts have been made to identify and quantify factors controlling invasibility of biological communities, less attention has been given to analyzing the expressions of vulnerability to nonindigenous species (NIS). Using the International Union for the Conservation of Nature and Natural Resources Red List database for birds, mammals, and amphibians and the Invasive Specie
Background: In a Nordic multi-centre study investigating the life and care situation of persons with schizophrenia living in the community, factors explaining use of health and social services were examined. Method: Four hundred and eighteen individuals with schizophrenia from 10 sites were interviewed about their contact with different services (support functions within and outside the mental hea
Context: Uncertainty is an unavoidable issue in software engineering and an important area of investigation. This paper studies the impact of uncertainty on total duration (i.e., make-span) for implementing all features in operational release planning. Objective: The uncertainty factors under investigation are: (1) the number of new features arriving during release construction, (2) the estimated
The doctoral dissertation is a key component of postgraduate education that plays an important role for knowledge production and hence the development of a discipline. Swedish human geography currently lacks an overview of dissertations. This article fills this knowledge gap by reporting findings from a unique database covering all doctoral dissertations between 1884 and 2015. The paper focuses on
A number of papers have provided insight into frequencies of violence-related trauma, especially skull trauma, in Northern European skeletal assemblages dating to the Neolithic and Bronze Age. Although the cases are often well described, they lack further discussion about the consequences of skull trauma for the injured individual and the implications for the surrounding society, especially consid
Background and Aims: To investigate the paraclinical and pathological features of surgically resected intraductal papillary mucinous neoplasms in Sweden. Materials and Methods: A review of prospectively collected data on patients undergoing pancreatic resection for a histopathologically verified intraductal papillary mucinous neoplasm between 2010 and 2016 was performed using the Swedish National
Background/Aims: We assessed how the novel PrisMax continuous renal replacement therapy (CRRT) system performed in a prospective international multicentre setting. We compared this device to its predecessor, the Prismaflex, with regards to multiple treatment parameters. Additionally, we performed a survey, aiming to measure user satisfaction. Methods: Data was prospectively collected from 7 intens
In this work, we perform large eddy simulations (LES) to study the influence of variable viscosity and thermal conductivity on forced convection in a non-isothermal channel flow. To prevent thermal dilatational effect, the gas density is assumed to be constant. The temperature ratio T2/T1 is varied from 1.01 to 2.2, where T2 and T1 are the temperatures of hot and cold walls, respectively. The mean
Lead time, defined as the duration between the moment a request was filed and the moment the decision was made, is an important aspect of decision making in market-driven requirements engineering. Minimizing lead time allows software companies to focus their resources on the most profitable functionality and enables them to remain competitive within the quickly changing software market. Achieving
In the near future, the number of connected mobile devices and data-rates are expected to dramatically increase. Demands exceed the capability of the currently deployed (4G) wireless communication systems. Development of 5G systems is aiming for higher data-rates, better coverage, backward compatibility, and conforming with “green communication” to lower energy consumption. Massive Multiple-Input
BACKGROUND: The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the prognostic value of the method in a group of patients receiving chemotherapy.METHODS: The automated method for detection of new lesions was evaluated in a group of 266 patients using t
Aims and objectives: To explore healthcare professionals' conceptions of caring for sick children in home care services. Background: Families often prefer home care to hospital care, and the number of home care services for children is increasing. Caring for children at home has been recognised as challenging for healthcare professionals in home care services used to providing care predominately f
The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS
Disease predisposing germline mutations in cancer susceptibility genes may consist of large genomic rearrangements, including deletions or duplications that are challenging, to detect and characterize using standard PCR-based mutation screening methods. Such rearrangements range from single exons up to hundreds of kilobases of sequence in size. Array-based comparative genomic hybridization (aCGH)
