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Engineered and devitalized hypertrophic cartilage (HC) has been proposed as bone substitute material, potentially combining the features of osteoinductivity, resistance to hypoxia, capacity to attract blood vessels, and customization potential for specific indications. However, in comparison with vital tissues, devitalized HC grafts have reduced efficiency of bone formation and longer remodeling t
BACKGROUND: The heritability of venous thromboembolism (VTE) is only partially explained by variants in 17 previously VTE-associated genes.OBJECTIVE: This article screens for additional rare variants in the 17 genes and investigates the relative contributions of pro- and anticoagulant genes to VTE.PATIENTS AND METHODS: Ninety-six VTE patients from the population-based Malmö Thrombophilia Study
Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technology (R-SAT). In vivo, 1 improved anabolic parameters in a 2-week chro
The pathophysiology of platelet dysfunction in the Wiskott-Aldrich immune deficiency syndrome (WAS) remains unclear. Using flow cytometry, we have characterized the functional properties of platelets from 10 children with WAS. Patients with WAS had thrombocytopenia, small platelets, increased platelet-associated IgG and reduced platelet-dense granule content. Levels of reticulated 'young' platelet
We propose a phenomenological model for the polygonal hydraulic jumps discovered by Ellegaard and co-workers, based on the known flow structure for the type-II hydraulic jumps with a "roller" (separation eddy) near the free surface in the jump region. The model consists of mass conservation and radial force balance between hydrostatic pressure and viscous stresses on the roller surface. In additio
Hepatocellular carcinoma (HCC), the third major cause of cancer mortality, can result from non-alcoholic steatohepatitis (NASH). Due to limited efficacy of drugs approved for HCC and no drug available yet for NASH, identification of new effective treatments is crucial. Here, we investigated whether NV556, a cyclophilin inhibitor derived from sanglifehrins, would decrease the development of NASH an
Neural transplantation in neurodegenerative diseases such as Parkinson’s disease (PD) offers to replace cells lost during the progression of the disease process. Primary fetal ventral mesencephalon (VM), the origin of bona fide midbrain dopaminergic (DAergic) precursors, is currently the gold standard source of cells for transplantation in PD. However, the use of tissue from this source raises eth
Organic material, about half of which is water soluble, constitutes nearly 80% of the wet-season aerosol mass in the Amazon Basin, while soluble inorganic salts (predominantly ammonium bisulfate) represent about 15%. A detailed analysis of number distributions and the size-dependent chemical composition of the aerosol indicates that, in principle, the sulfate fraction could account for most of the
Grammatical structure of Indo-European (IE) languages may appear to be diverse, but it is in fact more systematic than one may think. What is significant in explanation is alignment, i.e. differences represent different stages in the alignment change from active one to accusative one. This means that the grammatical structure was earlier organised by aspectual differences between perfective and im
Bound states in quantum dots coupled to superconductors can be in a coherent superposition of states with different electron number but with the same fermion parity. Electrostatic gating can tune this superposition to a sweet spot, where the quantum dot has the same mean electric charge independent of its electron-number parity. Here, we propose to encode quantum information in the local fermion p
Background: Stroke is a leading cause of acquired disability in adults worldwide, and the burden of stroke is projected to increase. Current long-term stroke outcome data including functional status, activity, and participation limitations as well as information on health-related quality of life (HRQoL) are vital for future rehabilitation and resource planning of stroke survivors. Methods: First-e
The 494 km long Latvian coast consists of sandy sediments, which serve as an excellent proxy for past coastal events and environment. Our study explores these understudied sediments along the western coast of the Gulf of Riga and combines two sand quartz-wise methods: optically stimulated luminescence (OSL) dating and grain microtextures. We provide a new chronology and microsedimentary results to
Regeneration of Norway spruce, Picea abies, forests is to a large extent depending on the production of seeds from high quality plus trees in orchards. However, the seed yield is variable and unpredictable due to weather, pest insects and diseases. Thus, more knowledge is needed to improve planning of harvest and mitigation of pests and diseases to secure future forest regeneration. In this study,
