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Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activat
A cell line derived from a tumor is a heterogeneous mixture of phenotypically different cells. Such cancer cell lines are used extensively in the search for new anticancer drugs and for investigating their mechanisms of action. Most studies today are population-based, implying that small subpopulations of cells, reacting differently to the potential drug go undetected. This is a problem specifical
By Marcelo Corrales Compagnucci, Janos Meszaros & Timo Minssen Empirical studies in behavioral economics have demonstrated how people are biased and often make poor decisions against their best interests. This has led policy makers to promote choice-preserving approaches, a.k.a. nudges. However, there has also been an increasingly vocal group of legal scholars who are interest in asking whethe
In the wake of the discovery of superheavy elements, nuclear spectroscopy experiments aim at providing anchor points at the uppermost end of the nuclear chart for nuclear structure theory, which otherwise had to solely rely on extrapolations. In two runs in 2019 and 2020, such a nuclear spectroscopy experiment was conducted to study α-decay chains stemming from isotopes of flerovium (element Z = 1
When different polling organisations conduct political party preference polls at different times, different parties might be reported. If the estimated voter shares of these polls are combined into a time series we obtain a compositional time series, but with varying number of parts, thus prohibiting the use of standard compositional time series analysis tools. We discuss the problem and suggest a
Anisotropy of gravitational wave (GW) emission results in a net momentum gained by the black hole (BH) merger product, leading to a recoil velocity up to ∼103 km s−1, which may kick it out of a globular cluster (GC). We estimate GW kick retention fractions of merger products assuming different models for BH spin magnitude and orientation. We check how they depend on BH–BH merger time and propertie
Neurodegenerative diseases (NDDs) are associated with genetic variations including point substitutions, copy number alterations, insertions and deletions. At present, a few genetic variation repositories for some individual NDDs have been created, however, these databases are needed to be integrated and expanded to all the NDDs for systems biological investigation. We here build a relational
Purpose: This paper deals with the impact Instagram has on consumers travel consumption. The aim of this paper is to analyse and create a deeper insight into how students travel consumption are affected by the pictures published on Instagram and how they are expressed. We also examine in which step of the buyer decision process Instagram affects travel consumption the most. Method: This study use
This thesis contains an examination of a method for quantitative phase imaging using lateral shearing interferometry. The focus is on how the degree of spatial coherence in the light source effect the image. The method is examined by first creating a simulation of the system, then looking at some analytical solutions for the interaction between some parameters, and finally conducting an experime
This study is an attempt to take advantage of a cerebellar model to control a biomimetic arm. Aware that a variety of cerebellar models with different levels of details has been developed, we focused on a high-level model called MOSAIC. This model is thought to be able to describe the cerebellar functionality without getting into the details of the neural circuitry. To understand where this model
In this thesis, a qualitative comparative case study has been conducted in five production companies. This has been made to get an understanding of how companies work with Lean and environmental management. Four interviews were conducted and two survey responses were received and there were eight open-ended questions where respondents were relatively free to talk about their experiences. The quest
There are many old buildings in Sweden today that in many aspects are worth saving for the future. Much focus is also on how to reduce the energy use in buildings. This theoretical study tries to give an example on that it is possible to combine these two parameters without risking the physical wellbeing or the aesthetic value of the building. The house in this report is situated in Vä, a communit
The aim of this thesis has been to examine the process of what material produced in the course of creating an exhibition that is considered worth keeping. The study has also intended to get an insight into attitudes and thoughts surrounding the archival function in the museum context. The result has been analyzed with basis in archival theory. Especially appraisal theory has been of great importan
Abstract Author: Frida Bengtsson Title: Just an ordinary upbringing… A study of the work on institutions for children and young people. Supervisor: Claes Levin Every year social secretaries making decisions about placing children and youths in different kinds of institutions, although research shows that it rarely has any positive effect on the youths. The purpose of this study was to examine how
The field of molecular phylogenetics is being revolutionized with next-generation sequencing technologies making it possible to sequence large numbers of genomes for non-model organisms ushering us into the era of phylogenomics. The current challenge is no longer how to get enough data, but rather how to analyse the data and how to assess the support for the inferred phylogeny. Here, we focus on o
Multireference complete active space self-consistent-field (CASSCF) and multireference CASSF second-order perturbation theory (MSCASPT2) calculations were performed on the ground state and a number of low-lying excited singlet and triplet states of chlorobenzene. The dual phosphorescence observed experimentally is clearly explained by the MSCASPT2 potential-energy curves. Experimental findings reg
The Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) instrument onboard the Rosetta spacecraft has measured molecular oxygen (O 2 ) in the coma of comet 67P/Churyumov-Gerasimenko (67P/C-G) in surprisingly high abundances. These measurements mark the first unequivocal detection of O
Context. V2492 Cyg is a young pre-main sequence star presenting repetitive brightness variations of significant amplitude (R - 5 mag) whose physical origin has been ascribed to both extinction (UXor-type) and accretion (EXor-type) variability, although their mutual proportion has not been clarified yet. Recently, V2492 Cyg has reached a level of brightness ever registered in the period of its docu
We establish support and resistance levels from data in intraday currency exchange market activity based on machine learning methods. Specifically we design two semi-supervised classification neural networks. The first one is based on a variant of the K-means method while the second is based on a Gaussian mixture model with expectation maximisation. Each performs classification from tick data on v
