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Aquaporins have emerged as one of the structurally best-characterized membrane protein families, with fourteen different structures available from a diverse range of organisms. While all aquaporins share the same fold and passive mechanism for water permeation, structural details allow for differences in selectivity and modes of regulation. These details are now the emphasis of aquaporin structura
The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops varies. Mathematical and computational analyses have suggested that loop complexity affects the overall flexibility of the oscillator, including
We present a digital phase-locked loop (DPLL) operating from 2.8 to 3.8 GHz with an on-chip 40-MHz reference crystal oscillator. The DPLL makes use of a class-D digitally controlled oscillator and a digital-to-time converter with a single-bit (bang-bang) phase detector. The DPLL displays an excellent behavior in terms of in-band fractional spurs, which are consistently below -65 dBc across the tun
Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To addr
This paper highlights and discusses the concept of the jubilee in Antiquity through a series of case studies. The ancient jubilee is defined as a temporally based, and often recurring, communal celebration, which encompasses longer time spans, from ten to a thousand years. The examples elaborated on by the present authors are: the Jewish Yovel, the Egyptian Heb-Sed and the Roman decennalia (Leande
Popular Abstract in Swedish Samarbete är ett värdeladdat ord i svenskt välfärdsarbete och inom socialt arbete förespråkas samarbete ofta som något värdefullt och nödvändigt. Idag finns det en stor, om än fragmenterad, vardagskunskap om samarbete och samverkan. Vetandet präglas dock av ett okritiskt accepterande av samarbetets fördelar, samtidigt som många verksamheter visar att resultaten av samarCo-operation is highly valued in Swedish welfare work and joint efforts within and between healthcare and welfare organizations is not new in Sweden. For decades the authorities have been trying to organize and coordinate various social and medical efforts in the public sector at a central level. This thesis is focusing on the meaning of co-operation between professionals belonging to different or
This thesis explores women’s access to property in Kenya. It consists of three parts. The first gives the Kenyan background, the theoretical and methodological approach. The second presents the findings in relation to the social construct of the gender and elaborates them in the contexts of women´s subsistence work, colonization and its aftermath and women´s formation of organizations. The third p
A number of screen-printed carbon electrodes (SPCEs) have been electrochemically studied revealing strong correlation between the reversibility of the Fe(CN)/Fe(CN) couple and the sensitivity for catechol at the same electrodes modified with cellobiose dehydrogenase (CDH). Pretreatment of the electrode surfaces increased both the heterogeneous ferricyanide reaction rate and the catechol sensitivit
The size and power of various generalization of the RESET test for functional misspecification are investigated, using the “Bootsrap critical values”, in systems ranging from one to ten equations. The properties of 8 versions of the test are studied using Monte Carlo methods. The results are then compared with another study of Shukur and Edgerton (2002), in which they used the asymptotic critical
Introduction: Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5-20% of subjects with a spine fracture are identified in primary care. We aimed to develop easily applicable algorithms predicting a high risk of future spine fracture in men and women over 50 years of age. Methods: Data was analysed from 5,561 men and women aged 50+ year
Objective: The atrioventricular (AV) node plays a central role in atrial fibrillation (AF) as it influences the conduction of impulses from the atria into the ventricles. In the present paper, the statistical dual pathway AV node model, previously introduced by us, is modified so that it accounts for atrial impulse pathway switching even if the preceding impulse did not cause a ventricular activat
Recent years have seen an increased interest in the transmuted probability models,which arise from transforming a “base” distribution into its generalized counterpart. While many standard probability distributions were generalized throughout this simple construction, the concept lacked deeper theoretical interpretation. This note demonstrates that the scheme is more than just a simple trick to obt
OBJECTIVES: We used GBD 2015 findings to measure the burden of intentional injuries in the Eastern Mediterranean Region (EMR) between 1990 and 2015.METHODS: The Global Burden of Disease (GBD) study defines intentional injuries as a combination of self-harm (including suicide), interpersonal violence, collective violence (war), and legal intervention. We estimated number of deaths, years of life lo
We conceptualize social capital as an aggregate factor affecting health production and analyze the effect of community social capital (CSC) externalities on individual mortality risk in Sweden. The study was based on a random sample from the adult Swedish population of approximately 95,000 individuals who were followed up for 4-21 years. Two municipality-level variables - registered election parti
When statistical linkage to a certain chromosomal region has been found, it is of interest to develop methods which quantify the accuracy with which the disease locus can be mapped. In this paper, we investigate the performance of three different types of confidence regions with asymptotically correct coverage probability as the number of pedigrees grows. Our setup is that of a saturated map of ma
The cysteinyl-leukotrienes (cysLTs: LTC4, LTD4 and LTE4) have an important pathophysiological role in asthma. They are not only extremely potent bronchoconstrictors, but are also involved in the central mechanisms of the asthmatic inflammation and the subsequent remodelling of the airways. Allergen-induced bronchoconstriction as well as spontaneous exacerbations of asthma are associated with incre
This paper presents a general criterion to classify a channel as micro-channel or macro-channel. Experimental results of saturated-flow boiling heat transfer in micro/mini-channels for both multi- and single-channel configurations were obtained from the literature. The collected database contains 4228 data points, covering a wide range of working fluids, operational conditions, and different micro
Many empirical studies of the economics of crime focus solely on the determinants thereof, and do not consider the dynamic and cross-sectional properties of their data. As a response to this, the current paper offers an in-depth analysis of this issue using data covering 21 Swedish counties from 1975 to 2010. The results suggest that the crimes considered are non-stationary, and that this cannot b
