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Expression of fibroblast growth factor-8 (FGF-8) is increased in a large number of breast cancers. In in vitro and in vivo breast cancer models FGF-8 promotes growth, invasion and angiogenesis. In the present work we have studied the mechanisms by which FGF-8b and its receptors (FGFR1-3) promote breast cancer cell growth using S115 murine and human MCF-7 breast cancer cell lines in in vitro and i
Objective. To investigate the type of urinary diversion performed after cystectomy in patients with muscle-invasive bladder cancer in Sweden, using data from a population-based national register. Material and methods. Since 1997, the Swedish Bladder Cancer Register has included more than 90% of all patients with newly diagnosed bladder cancer. The different types of urinary diversion performed in
Context. The astrometric solution for Gaia aims to determine at least five parameters for each star, representing its position, parallax, and proper motion, together with appropriate estimates of their uncertainties and correlations. This requires at least five distinct observations per star. In the early data reductions the number of observations may be insufficient for a five-parameter solution,
Context. The Gaia satellite will observe about one billion stars and other point-like sources. The astrometric core solution will determine the astrometric parameters (position, parallax, and proper motion) for a subset of these sources, using a global solution approach which must also include a large number of parameters for the satellite attitude and optical instrument. The accurate and efficien
Background: Osteoporosis is a common bone disease, which does not give symptoms until the ultimate outcome, the fragility fracture occurs. Regulation of bone mass is controlled by genetic, environmental and nutritional influences. Peak bone mass, defined as the maximum bone mass accrued, is usually reached by the third decade of life and is an important determinant of future osteoporotic fracture.
Regional climate models (RCMs) are used for forecasting future climate including precipitation characteristics. Performances of five different RCMs for predicting the precipitation characteristics for Gothenburg, Sweden were evaluated against the daily observed precipitation over the period 1961 to 2009. Statistical analysis was done on annual, monthly, multi-daily, and daily data. The statistical
Popular Abstract in Swedish Kontrakt som handlas på de internationella finans- och råvarumarknaderna är förenade med komplexa riskstrukturer. Denna avhandling behandlar två specifika typer av risk; marknadsrisk och kreditrisk. Det första kapitlet i avhandlingen undersöker marknadsrisker på den Nordiska elmarknaden. Vi utför in-sample och out-of-sample backtesting av en VaR-modell baserad på GARCContracts traded on international financial and commodity markets are associated with complex risk structures. In this dissertation we are concerned with two specific types of risks; market risks and credit risks. The first chapter investigates market risks in the context of the Nordic electricity market. The paper performs in- and out-of-sample backtesting of a VaR model based on GARCH volatili
We propose an energy-based framework for approximating surfaces from a cloud of point measurements corrupted by noise and outliers. Our energy assigns a tangent plane to each (noisy) data point by minimizing the squared distances to the points and the irregularity of the surface implicitly defined by the tangent planes. In order to avoid the well-known "shrinking" bias associated with first-order
The Lepidoptera fauna of the Danish island of Anholt is surveyed, and 1160 species are recorded. Anholt is situated in Kattegat 44 km from Denmark and 47 km from Sweden. The history and environment of the island are briefly discussed, with special focus on the flora, and earlier studies of the Lepidopterera fauna of Anholt are dealt with. The present study is in first hand based on material collec
Popular Abstract in Swedish För firande av mässa i den katolska kyrkan krävs ett altare av sten. Altaret ska invigas av en biskop enligt en viss ritual. Ett viktigt element i altarinvigningsritualen är placeringen av reliker i altarets inre. Före reformationen på 1500-talet gällde denna regel även i Norden. Trots altarnas centrala betydelse i den medeltida nordiska kyrkan har de ägnats liten uppmäThis dissertation deals with the subject of altars in the churches of the medieval diocese of Lund. The main work on altars in the Catholic church is Joseph Braun´s Der christliche Altar in seiner geschichtlichen Entwicklung (1924). However, despite its extensive content it does not deal with the conditions in Northern Europe. The general aim of this dissertation is to broaden our knowledge about
A simple and fast method is presented to be used for example in studies on the relationship between serum levels of persistent organic pollutants and type 2 diabetes mellitus. Method is based on liquid-liquid extraction and gas chromatography coupled with high.-resolution mass spectrometry. In the sample pretreatment special attention was paid to minimize the number of sample manipulation steps an
The sustainable development of a software product depends on a number of groups working together to achieve a common goal. However, each of the groups interacts with the product in different ways, and can have conflicting aims and objectives. For example, developers trying to correct issues in the software architecture, which will impact future releases of the product, can be stopped by a project
This book is dedicated to professor emeritus Bengt Forkman (Nuclear Physics, Lund University) who in 1979 took the initiative to arrange an environmental radioactivity research program for the Ymer-80 expedition. He engaged his old friend Bertil Persson whom he during the 1960th inspired to university studies in Lund who just been promoted to professor of Radioecology at the Swedish University of
Human cytomegalovirus (HCMV)-infected cells express a virus-encoded receptor that is able to bind the Fc part of IGG: Some basic binding properties of this Fc receptor (FcR) have been examined. The affinity constant (K(a)) for human IgG Fc fragment in its interaction with acetone-fixed, HCMV-infected human embryonic lung fibroblasts was estimated to be around 2 x 10(8) M(-1) and the number of bind
Objective: The Swedish Registry for Active Treatment of Uraemia (SRAU) was founded in 1991 with the objective of documenting demographic data on patients treated for end-stage renal disease (ESRD). The aim of this study was to describe the prevalence, incidence, comorbidity risk factors and survival of patients with ESRD who underwent dialysis treatment and/or kidney transplantation in Sweden betw
Popular Abstract in Swedish Under de senaste decennierna har våra skogar utsatts för en allt högre grad av stress som en följd av förändrade produktionsmönster och en hög deposition av gödande och försurande ämnen, såsom kväve ovh svavel. Kväve är det ämne som begränsar trädens tillväxt, och det höga nedfallet av detta ämne har resulterat i att träden växt mycket snabbbare. Deras behov av andra näForests in Sweden are undergoing rapid and considerable changes regarding both management methods and environmental conditions. To understand the effects of these changes and to be able to predict impending changes in forest ecosystems, a holistic understanding of the processes governing the ecosystem is needed. To gain such an understanding, the ForSAFE model of the biogeochemical cycles in a for
Aim: The study investigated clinical and social changes during an 18-month follow-up period in a group (n = 76) of schizophrenic outpatients admitted to a newly implemented outpatient psychosis team. Changes related to level of contact with the psychosis team were also examined as well as aspects of the content of the treatment interventions and work situation from a staff perspective. Methods: St
Background: Assessing RNA quality is essential for gene expression analysis, as the inclusion of degraded samples may influence the interpretation of expression levels in relation to biological and/ or clinical parameters. RNA quality can be analyzed by agarose gel electrophoresis, UV spectrophotometer, or microcapillary electrophoresis traces, and can furthermore be evaluated using different meth
Popular Abstract in Swedish Den nuvarande teknologin inom förbränningsmotorer har möjligheten att hantera den alltmer strikta myndighetskraven på förbränningsmotorn. Emellertid de nödvändiga tekniska lösningarna som krävs är dyra och alltmer tekniskt krävande. En möjlig väg mot enklare efterbehandlingssystem är anvädningen av Homogen Kompressions Antändning (Eng: HCCI) motor cykeln. Den huvudsaklThe current technology within combustion engines have the possibility of handling the more stringent legislative demands on combustion engines. However the required solutions are getting more expensive and technically challenging. One possible way towards a more simple exhaust aftertreatment system is the use of the Homogeneous Charge Compression Ignition (HCCI) engine cycle. The main advantage o
